Current Efavirenz (EFV) or ritonavir-boosted lopinavir (LPV/r) use correlates with elevate markers of atherosclerosis in HIV-infected subjects in Addis Ababa, Ethiopia.

Autor: Rudolph L Gleason, Alexander W Caulk, Daniel Seifu, Ivana Parker, Brani Vidakovic, Helena Getenet, Getachew Assefa, Wondwossen Amogne

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0117125 (2015)

HIV patients on antiretroviral therapy have shown elevated incidence of dyslipidemia, lipodystrophy, and cardiovascular disease (CVD). Most studies, however, focus on cohorts from developed countries, with less data available for these co-morbidities

Externí odkaz: https://doaj.org/article/ef2932fe3f544948958f15f778445b42

Western diet-induced obesity results in brain mitochondrial dysfunction in female Ossabaw swine

Autor: Taylor J. Kelty, Chris L. Taylor, Nicole E. Wieschhaus, Pamela K. Thorne, Amira R. Amin, Christina M. Mueller, T. Dylan Olver, Darla L. Tharp, Craig A. Emter, Alexander W. Caulk, R. Scott Rector

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Diet-induced obesity is implicated in the development of a variety of neurodegenerative disorders. Concurrently, the loss of mitochondrial Complex I protein or function is emerging as a key phenotype across an array of neurodegenerative disorders. Th

Externí odkaz: https://doaj.org/article/77e17acae05643758ef8bc4dc5d12d33

P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

Autor: Bart Spronck, Marcos Latorre, Sameet Mehta, Alexander W. Caulk, Abhay B. Ramachandra, Sae-Il Murtada, Alexia Rojas, Chang-Sun He, Bo Jiang, Mo Wang, Matthew R. Bersi, George Tellides, Jay D. Humphrey

Publikováno v: Artery Research, Vol 26, Iss Supplement 1 (2020)

Background: Many genetic mutations affect aortic structure and function in mice, but little is known about the influence of background strain. We compared the biomechanical, structural, and gene expression responses of C57BL/6J and 129SvEv aortas to

Externí odkaz: https://doaj.org/article/f9e99ab41e174142b9583efea9961b72

Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging

Autor: Jacopo Ferruzzi, Jay D. Humphrey, Bart Spronck, Alexander W. Caulk, Sae-Il Murtada, Chiara Bellini

Publikováno v: Journal of Hypertension, 38(7), 1312-1321. LIPPINCOTT WILLIAMS & WILKINS
Journal of hypertension
Journal of Hypertension

Objectives Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it has been difficult to separate their effects. Herein, we st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f573452436a8b2ae94427a5177b90852
https://doi.org/10.1097/HJH.0000000000002400

Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice

Autor: Mo Wang, Chang-Shun He, Bart Spronck, George Tellides, Alexia Rojas, Matthew R. Bersi, Bo Jiang, Marcos Latorre, Sameet Mehta, Abhay B. Ramachandra, Alexander W. Caulk, Sae-Il Murtada, Pengwei Ren, Jay D. Humphrey

Publikováno v: Journal of the Royal Society. Interface
J R Soc Interface
Journal of the Royal Society Interface, 18(180):20210336. The Royal Society of New Zealand

[EN] Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To identify immuno-mechanical mechanisms responsible for differential remodelling, we studied thoracic aortas from 129S6/SvEvTac and C57BL/6 J mice before and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489c5436b2c4af00db2bfb62e2ee9e68
https://doi.org/10.1098/rsif.2021.0336