Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Alexander W, Wyatt"'
Autor:
Nicolette M. Fonseca, Corinne Maurice-Dror, Cameron Herberts, Wilson Tu, William Fan, Andrew J. Murtha, Catarina Kollmannsberger, Edmond M. Kwan, Karan Parekh, Elena Schönlau, Cecily Q. Bernales, Gráinne Donnellan, Sarah W. S. Ng, Takayuki Sumiyoshi, Joanna Vergidis, Krista Noonan, Daygen L. Finch, Muhammad Zulfiqar, Stacy Miller, Sunil Parimi, Jean-Michel Lavoie, Edward Hardy, Maryam Soleimani, Lucia Nappi, Bernhard J. Eigl, Christian Kollmannsberger, Sinja Taavitsainen, Matti Nykter, Sofie H. Tolmeijer, Emmy Boerrigter, Niven Mehra, Nielka P. van Erp, Bram De Laere, Johan Lindberg, Henrik Grönberg, Daniel J. Khalaf, Matti Annala, Kim N. Chi, Alexander W. Wyatt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract No consensus strategies exist for prognosticating metastatic castration-resistant prostate cancer (mCRPC). Circulating tumor DNA fraction (ctDNA%) is increasingly reported by commercial and laboratory tests but its utility for risk stratific
Externí odkaz:
https://doaj.org/article/6914ec1e3ba942ee99b1463117270db9
Autor:
Elie J. Ritch, Cameron Herberts, Evan W. Warner, Sarah W. S. Ng, Edmond M. Kwan, Jack V. W. Bacon, Cecily Q. Bernales, Elena Schönlau, Nicolette M. Fonseca, Veda N. Giri, Corinne Maurice-Dror, Gillian Vandekerkhove, Steven J. M. Jones, Kim N. Chi, Alexander W. Wyatt
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract Specific classes of DNA damage repair (DDR) defect can drive sensitivity to emerging therapies for metastatic prostate cancer. However, biomarker approaches based on DDR gene sequencing do not accurately predict DDR deficiency or treatment b
Externí odkaz:
https://doaj.org/article/857049a6c5d347b5818113b423d91b16
Autor:
Sujun Chen, Jessica Petricca, Wenbin Ye, Jiansheng Guan, Yong Zeng, Nicholas Cheng, Linsey Gong, Shu Yi Shen, Junjie T. Hua, Megan Crumbaker, Michael Fraser, Stanley Liu, Scott V. Bratman, Theodorus van der Kwast, Trevor Pugh, Anthony M. Joshua, Daniel D. De Carvalho, Kim N. Chi, Philip Awadalla, Guoli Ji, Felix Feng, Alexander W. Wyatt, Housheng Hansen He
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Metastatic prostate cancer can be difficult to biopsy and characterise. Here, the authors use cell-free DNA methylation analysis to illustrate changes in hypermethylation in metastatic disease.
Externí odkaz:
https://doaj.org/article/7b26255c7880443b834672c94a98b048
Autor:
Davide Tortora, Morgan E. Roberts, Gunjan Kumar, Sudha S. Kotapalli, Elie Ritch, Joshua M. Scurll, Brian McConeghy, Sunita Sinha, Alexander W. Wyatt, Peter C. Black, Mads Daugaard
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106525- (2023)
Summary: Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor central in the regulation of key cellular processes including cell metabolism, tissue differentiation, and regulation of the immune system. PPARγ is required fo
Externí odkaz:
https://doaj.org/article/f77ff7431c4342bdb81350390eef33b5
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Plasma circulating tumor DNA (ctDNA) represents short fragments of tumor-derived DNA released into the bloodstream primarily from cancer cells undergoing apoptosis. In metastatic castration-resistant prostate cancer (mCRPC), characterizing genomic al
Externí odkaz:
https://doaj.org/article/d3e97f73c3e54ff8a073b948c1df6d30
Publikováno v:
Société Internationale d’Urologie Journal, Vol 2, Iss Suppl. 1, Pp 1-22 (2021)
None.
Externí odkaz:
https://doaj.org/article/c8fc3b0e37cb442e863c486dfffbc846
Autor:
David Gonzalez, Joaquin Mateo, Albrecht Stenzinger, Federico Rojo, Michelle Shiller, Alexander W Wyatt, Frédérique Penault‐Llorca, Leonard G Gomella, Ros Eeles, Anders Bjartell
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 4, Pp 311-325 (2021)
Abstract Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP‐ribose) polymerase (PARP) inhibitors olaparib a
Externí odkaz:
https://doaj.org/article/6c8a0e9ecaee491db42b93bea2700669
Autor:
Emmalyn Chen, Clinton L. Cario, Lancelote Leong, Karen Lopez, César P. Márquez, Carissa Chu, Patricia S. Li, Erica Oropeza, Imelda Tenggara, Janet Cowan, Jeffry P. Simko, June M. Chan, Terence Friedlander, Alexander W. Wyatt, Rahul Aggarwal, Pamela L. Paris, Peter R. Carroll, Felix Feng, John S. Witte
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Prostate cancer is the most commonly diagnosed neoplasm in American men. Although existing biomarkers may detect localized prostate cancer, additional strategies are necessary for improving detection and identifying aggressive disease that m
Externí odkaz:
https://doaj.org/article/3bda01622d5a48dca54ff3356e239cb8
Autor:
Gillian Vandekerkhove, Jean-Michel Lavoie, Matti Annala, Andrew J. Murtha, Nora Sundahl, Simon Walz, Takeshi Sano, Sinja Taavitsainen, Elie Ritch, Ladan Fazli, Antonio Hurtado-Coll, Gang Wang, Matti Nykter, Peter C. Black, Tilman Todenhöfer, Piet Ost, Ewan A. Gibb, Kim N. Chi, Bernhard J. Eigl, Alexander W. Wyatt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In metastatic urothelial carcinoma, it has not been established whether circulating tumor DNA (ctDNA) can replace archival primary tissue to assess mutations and biomarkers. Here, the authors show high mutation concordance between ctDNA and tumour ti
Externí odkaz:
https://doaj.org/article/a2f42ea8d98a4db587379bb0ba66d3fe
Autor:
Jean-Michel Lavoie, Gillian Vandekerkhove, Andrew J. Murtha, Gang Wang, Alexander W. Wyatt, Bernhard J. Eigl
Publikováno v:
Urology Case Reports, Vol 39, Iss , Pp 101762- (2021)
The management of metastatic urothelial cancer is rapidly evolving since immune checkpoint inhibitors were introduced. We present the case of a patient with metastatic upper tract urothelial cancer who had a complete response to durvalumab and tremel
Externí odkaz:
https://doaj.org/article/ff2ebdbc93ad43f0bb25309772f79d18