Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alexander Vladimirsky"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 6, p e1012165 (2024)
Although adaptive cancer therapy shows promise in integrating evolutionary dynamics into treatment scheduling, the stochastic nature of cancer evolution has seldom been taken into account. Various sources of random perturbations can impact the evolut
Externí odkaz:
https://doaj.org/article/f3365eb8ae534a3f93a56a9f92a2794d
While adaptive cancer therapy is beginning to prove a promising approach of building evolutionary dynamics into therapeutic scheduling, the stochastic nature of cancer evolution has rarely been incorporated. Various sources of random perturbations ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e377a08da0dc8aa07a35e48fe44456
https://doi.org/10.1101/2022.06.17.496649
https://doi.org/10.1101/2022.06.17.496649
Autor:
Elliot Cartee, Alexander Vladimirsky
Publikováno v:
SIAM Journal on Applied Mathematics. 80:1441-1466
We present two models of perpetrators' decision-making in extracting resources from a protected area. It is assumed that the authorities conduct surveillance to counter the extraction activities, and that perpetrators choose their post-extraction pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1440f3d57cfc64ffba6dbc059cf9b4e5
https://doi.org/10.1137/19m1270483
https://doi.org/10.1137/19m1270483
We study driver's optimal trajectory planning under uncertainty in the duration of a traffic light's green phase. We interpret this as an optimal control problem with an objective of minimizing the expected cost based on the fuel use, discomfort from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66972d83f8085f23c490394966a72033
Autor:
Cole Miles, Alexander Vladimirsky
In match race sailing, competitors must steer their boats upwind in the presence of unpredictably evolving weather. Combined with the tacking motion necessary to make upwind progress, this makes it natural to model their path-planning as a hybrid sto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940063417919ed38c68e1de2b053e307
http://arxiv.org/abs/2109.08260
http://arxiv.org/abs/2109.08260
Publikováno v:
Dynamic Games and Applications. 10:391-416
The classical setting of optimal control theory assumes full knowledge of the process dynamics and the costs associated with every control strategy. The problem becomes much harder if the controller only knows a finite set of possible running cost fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f15b7ccca8190e2ffaf02952886dd30
https://doi.org/10.1007/s13235-019-00327-x
https://doi.org/10.1007/s13235-019-00327-x
Autor:
Alexander Vladimirsky, Marissa Gee
We propose a model for path-planning based on a single performance metric that accurately accounts for the the potential (spatially inhomogeneous) cost of breakdowns and repairs. These random breakdowns (or system faults) happen at a known, spatially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d6ec54ffe20fc1a6ae4a58eabfd796
Publikováno v:
Journal of Optimization Theory and Applications. 175:795-817
We present an efficient method for solving optimal stopping problems with a probabilistic constraint. The goal is to optimize the expected cumulative cost, but constrained by an upper bound on the probability that the cost exceeds a specified thresho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::227cf40671dc1f80bdd3e0142eaf09e0
https://doi.org/10.1007/s10957-017-1183-3
https://doi.org/10.1007/s10957-017-1183-3
Publikováno v:
CDC
Surveillance-Evasion (SE) games form an important class of adversarial trajectory-planning problems. We consider time-dependent SE games, in which an Evader is trying to reach its target while minimizing the cumulative exposure to a moving enemy Obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a9dbcf4859f20225e5ee2809c45db6
Publikováno v:
Proc Biol Sci
Recent clinical trials have shown that the adaptive drug therapy can be more efficient than a standard MTD-based policy in treatment of cancer patients. The adaptive therapy paradigm is not based on a preset schedule; instead, the doses are administe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892a62052dcef5c33edbecb997706710