Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexander Viktorovich Khvat"'
Autor:
Arturo Galvani, Daniele Donati, Emiliana Corti, Alessandra Cirla, Paolo Orsini, Elena Casale, Francesco Sola, Mikhail Krasavin, Marina Fasolini, Enrico Pesenti, Barbara Forte, Rita Perego, Antonella Isacchi, Alina Busel, Daniela Borghi, Alessia Montagnoli, Fabio Zuccotto, Federico Riccardi-Sirtori, Eduard R. Felder, Helena Posteri, Rosita Lupi, Alexander Viktorovich Khvat, Marina Ciomei, Daniele Pezzetta, Gianluca Papeo, Matteo D'anello, Sonia Rainoldi, Francesco Caprera, Alessandra Scolaro
Publikováno v:
Journal of Medicinal Chemistry. 58:6875-6898
The nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) has a well-established role in the signaling and repair of DNA and is a prominent target in oncology, as testified by the number of candidates in clinical testing that unselectively target bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155b01fe1feb286b71832148160cb556
https://doi.org/10.1021/acs.jmedchem.5b00680
https://doi.org/10.1021/acs.jmedchem.5b00680
Autor:
Denise E. Lackey, Ruth T. Yu, Christopher Liddle, Alexander Viktorovich Khvat, Sungsoon Fang, Sandra Jacinto, David A. Brenner, Alan R. Saltiel, Jae Myoung Suh, Kristina Schoonjans, Alessia Perino, Elizabeth Yu, Yelizaveta Lukasheva, Bernd Schnabl, Sally Coulter, Ronald M. Evans, Michael Downes, Annette R. Atkins, Olivia Osborn, Jerrold M. Olefsky, Shannon M. Reilly, Eiji Yoshihara
Publikováno v:
Nature medicine
Nature medicine, vol 21, iss 2
Nature medicine, vol 21, iss 2
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8594f0afa07a52e99e16c0fb39d38e0a
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320010/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320010/
Autor:
Sergey Tkachenko, Volodymyr M. Kysil, Alexander Viktorovich Khvat, Alexandre V. Ivachtchenko, Marina Churakova, Caroline Williams, Sergey Tsirulnikov
Publikováno v:
European Journal of Organic Chemistry. 2010:1525-1543
Multicomponent reactions of primary 1,2- and 1,3-diamines with carbonyl compounds and isocyanides resulting in the formation of diverse 2-amino-1,4-diazaheterocycles are described. Lewis acids (LAs) promote the reactions effectively, and chlorotrimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff928437f49bd02327700a500686a4f6
https://doi.org/10.1002/ejoc.200901360
https://doi.org/10.1002/ejoc.200901360
Autor:
Oleg D. Mitkin, Alexandre Vasilievich Ivachtchenko, S. E. Tkachenko, Ilya Okun, V. I. Kazey, Alexander Viktorovich Khvat
Publikováno v:
Current Alzheimer Research. 7:97-112
Dimebon, originally developed as an anti-histamine drug, is being re-purposed for new indications as an effective treatment for patients suffering from Alzheimer's and Huntington's diseases, albeit with an as-yet unknown mechanism of action. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2108d032573c47bc7506292dd2ed025a
https://doi.org/10.2174/156720510790691100
https://doi.org/10.2174/156720510790691100
Autor:
Alexander Viktorovich Khvat, Oleg D. Mitkin, Ilya Okun, Eugene B. Frolov, Sergey E. Tkachenko, Volodymyr M. Kysil, Alexandre V. Ivachtchenko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3183-3187
Synthesis, biological evaluation and structure-activity relationships for a series of novel gamma-carboline analogues of Dimebon are described. Among the studied compounds, gamma-carbolines 3{8} and 3{14} have been identified as potent small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ec6d314f76aff5a5becd1df52ad284
https://doi.org/10.1016/j.bmcl.2009.04.128
https://doi.org/10.1016/j.bmcl.2009.04.128
Autor:
Boris V. Rogovoy, Alexander V. Ivachtchenko, Matthew A. Parker, Frederick J. Lakner, Alexander Viktorovich Khvat
Publikováno v:
Synthesis. 2009:1987-1990
Imidazolines substituted at the 1- and either the 4-, or 5-position with phenyl and at the 2-position with alkyl or phenyl have been prepared in racemic form. They appear to be fairly stable compounds and potentially useful as scaffolds in medicinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b6a4bddad89d70941fca270664e46f
https://doi.org/10.1055/s-0029-1216784
https://doi.org/10.1055/s-0029-1216784
Autor:
Alexander Viktorovich Khvat, Tetyana Beryozkina, F. G. Yaremenko, Irina Svidlo, Svetlana V. Shishkina, Oleg V. Shishkin, Valeriy D. Orlov
Publikováno v:
Journal of Molecular Structure. 874:57-63
Reaction of 2-aminothiazoline ( 1 ) with α,β-unsaturated carbonyl compounds 2 under mild conditions (acetone, room temperature) gives two diastereomers 5-R-7-hydroxy-5 H -tetrahydrothiazolo[2,3- a ]pyrimidines 3 . According to 1 H NMR, major isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::115f90c63588f2b3e594e3e577bb671f
https://doi.org/10.1016/j.molstruc.2007.03.031
https://doi.org/10.1016/j.molstruc.2007.03.031
Autor:
Volodymyr M. Kysil, Caroline Williams, Alexander Viktorovich Khvat, Sergey Tsirulnikov, Marina Churakova, Sergey Tkachenko, Alexandre V. Ivachtchenko
Publikováno v:
Tetrahedron Letters. 48:6239-6244
New trimethylchlorosilane (TMSCl) promoted multicomponent reaction (MCR) of ethylenediamine(s), diverse carbonyl compounds, and isocyanides is proposed for the synthesis of a variety of highly substituted 3,4,5,6-tetrahydropyrazin-2-amines including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2012a15435239e69ffa08a0fcae80778
https://doi.org/10.1016/j.tetlet.2007.07.044
https://doi.org/10.1016/j.tetlet.2007.07.044
Autor:
Alexandre V. Ivachtchenko, Alexander Viktorovich Khvat, Sergey E. Tkachenko, Sergei Malarchuk, Dmitry V. Kravchenko, Elena Dubrovskaya, Volodymyr M. Kysil, Ilya Okun
Publikováno v:
SLAS Discovery. 11:694-703
When studying cysteinyl proteases in general and caspases in particular, it is generally accepted that a reaction buffer must contain a reducing agent to prevent essential cysteinyl groups from spontaneous oxidation. Dithiothreitol (DTT) and beta-mer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912e9afbcb657bee9c7d7b159d482f44
https://doi.org/10.1177/1087057106289231
https://doi.org/10.1177/1087057106289231
Autor:
Sergei Malarchuk, Alexey P. Ilyin, Sergey E. Tkachenko, Eric R. Prossnitz, Elena Dubrovskaya, Dmitry V. Kravchenko, Larry A. Sklar, Alexander Viktorovich Khvat, Volodymyr M. Kysil, Ilya Okun, Alexandre V. Ivachtchenko
Publikováno v:
SLAS Discovery. 11:277-285
From the authors' 650,000 compound collection, they have selected approximately 15,000 potential small-molecule protease inhibitors, which were subjected to high-throughput screening against caspase-3. The screening yielded a series of hits that belo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93568578b7c6959bccefccd83ce729a3
https://doi.org/10.1177/1087057105285048
https://doi.org/10.1177/1087057105285048