Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Alexander Van Parys"'
Autor:
Willem Daneels, Alexander Van Parys, Leander Huyghe, Elke Rogge, Steffi De Rouck, Ruben Christiaen, Lennart Zabeau, Sylvie Taveirne, Jo Van Dorpe, Niko Kley, Anje Cauwels, Erik Depla, Jan Tavernier, Fritz Offner
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Type I interferon (IFN) is a potent antitumoral drug, with an important history in the treatment of hematologic malignancies. However, its pleiotropic nature leads to severe dose-limiting toxicities that blunt its therapeutic potential. To a
Externí odkaz:
https://doaj.org/article/c7a5f686a979439ab7a58e3892219770
Autor:
Sandra Van Lint, Alexander Van Parys, Bram Van Den Eeckhout, Niels Vandamme, Stephane Plaisance, Annick Verhee, Dominiek Catteeuw, Elke Rogge, Jennifer De Geest, Nele Vanderroost, Jana Roels, Yvan Saeys, Gilles Uzé, Niko Kley, Anje Cauwels, Jan Tavernier
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major obstacle for the induction of efficient antitumor responses. In this study, we show that local delivery of a bispecific
Externí odkaz:
https://doaj.org/article/72e457857a534bb8861f2b6b4e37b51c
Autor:
Jared E Lopes, Anje Cauwels, Niko Kley, Lennart Zabeau, Alexander Van Parys, Sylvie Taveirne, Erik Depla
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/475be55bc8db427ebeed963bf99410c1
Autor:
Robin Maximilian Awad, Quentin Lecocq, Katty Zeven, Thomas Ertveldt, Lien De Beck, Hannelore Ceuppens, Katrijn Broos, Yannick De Vlaeminck, Cleo Goyvaerts, Magali Verdonck, Geert Raes, Alexander Van Parys, Anje Cauwels, Marleen Keyaerts, Nick Devoogdt, Karine Breckpot
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 22, Iss , Pp 172-182 (2021)
Monoclonal antibodies that target the inhibitory immune checkpoint axis consisting of programmed cell death protein 1 (PD-1) and its ligand, PD-L1, have changed the immune-oncology field. We identified K2, an anti-human PD-L1 single-domain antibody f
Externí odkaz:
https://doaj.org/article/a02773e0d7c64fbda016a0f01cb0fe31
Autor:
Leander Huyghe, Alexander Van Parys, Anje Cauwels, Sandra Van Lint, Stijn De Munter, Jennyfer Bultinck, Lennart Zabeau, Jeroen Hostens, An Goethals, Nele Vanderroost, Annick Verhee, Gilles Uzé, Niko Kley, Frank Peelman, Bart Vandekerckhove, Peter Brouckaert, Jan Tavernier
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp n/a-n/a (2020)
Abstract Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index. A TN
Externí odkaz:
https://doaj.org/article/0c182dbd4d474d4e99086c5f110eebd3
Autor:
Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker, Xavier Saelens
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Necroptosis has immunogenic cell death properties. Here, the authors show that the intra-tumor delivery of mRNA that codes for the necroptosis effector MLKL triggers neo-epitope-specific anti-tumor T cell responses and inhibits primary tumor growth a
Externí odkaz:
https://doaj.org/article/8238d6be45a64c8a92375d54457b3e83
Autor:
Stijn De Munter, Alexander Van Parys, Layla Bral, Joline Ingels, Glenn Goetgeluk, Sarah Bonte, Melissa Pille, Lore Billiet, Karin Weening, Annick Verhee, Jose Van der Heyden, Tom Taghon, Georges Leclercq, Tessa Kerre, Jan Tavernier, Bart Vandekerckhove
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 883 (2020)
Recent approval of chimeric antigen receptor (CAR) T cell therapy by the European Medicines Agency (EMA)/Federal and Drug Administration (FDA) and the remarkable results of CAR T clinical trials illustrate the curative potential of this therapy. Whil
Externí odkaz:
https://doaj.org/article/83a54f189b9d4f34951f075863969ccb
Autor:
Venessa Eeckhaut, Jun Wang, Alexander Van Parys, Freddy Haesebrouck, Marie Joossens, Gwen Falony, Jeroen Raes, Richard Ducatelle, Filip Van Immerseel
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
In the past the use of in-feed antibiotics has been the main strategy to improve health, nutrient availability and growth performance by selectively modifying the gut microbiota. Due to consumer concerns about the threat of antibiotic-resistant bacte
Externí odkaz:
https://doaj.org/article/926d3fd5092740af95184a1ca763bfd2
Autor:
Alexander Van Parys, Filip Boyen, Bregje Leyman, Elin Verbrugghe, Freddy Haesebrouck, Frank Pasmans
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24120 (2011)
Salmonellosis caused by Salmonella Typhimurium is one of the most important bacterial zoonotic diseases. The bacterium persists in pigs resulting in asymptomatic 'carrier pigs', generating a major source for Salmonella contamination of pork. Until no
Externí odkaz:
https://doaj.org/article/e30abd4d79a7444ea4d5fac292a03e77
Autor:
Jan Tavernier, Gilles Uzé, Niko Kley, Bart Vandekerckhove, Annick Verhee, Elke Rogge, Dominiek Catteeuw, Yann Bordat, José Van der Heyden, Sarah Gerlo, Thomas Wueest, Alexander Van Parys, Stefaan De Koker, Geneviève Garcin, Franciane Paul, Sandra Van Lint, Anje Cauwels
Combination treatments of B16 tumors with Clec9A-mAFN do not cause toxicity, in contrast to combinations with WT mIFN.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10da8f73a034c988aea8adf63797b9c7
https://doi.org/10.1158/0008-5472.22418085
https://doi.org/10.1158/0008-5472.22418085