Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Alexander V. Yakhnin"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Transcription by bacterial RNA polymerase is interrupted by pausing events that play diverse regulatory roles. Here, the authors find that a large number of E. coli sigma70-dependent pauses, clustered at a 10−20-bp distance from promoters, are regu
Externí odkaz:
https://doaj.org/article/a3fc4f3397f444a2a4e04ebfd6d6f34c
Autor:
Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Macrolide antibiotics bind to 23S rRNA within the peptide exit tunnel of the ribosome, causing the translating ribosome to stall when an appropriately positioned macrolide arrest motif is encountered in the nascent polypeptide. Tylosin is a
Externí odkaz:
https://doaj.org/article/9d25a70e7bc14faa966d3a8d0b96310c
Autor:
Zachary F Mandell, Reid T Oshiro, Alexander V Yakhnin, Rishi Vishwakarma, Mikhail Kashlev, Daniel B Kearns, Paul Babitzke
Publikováno v:
eLife, Vol 10 (2021)
NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the role of NusG in this process was unknown. To examine the indiv
Externí odkaz:
https://doaj.org/article/1f0c0d49764849a08ca298f3f24f699d
Autor:
Oshadhi T. Jayasinghe, Zachary F. Mandell, Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke
Publikováno v:
J Bacteriol
Transcription elongation is a highly processive process that is punctuated by RNA polymerase (RNAP) pausing. Long-lived pauses can provide time for diverse regulatory events to occur, which play important roles in modulating gene expression. Transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c3fb38e9c768a67c0140dd8a540e0c
https://europepmc.org/articles/PMC9112975/
https://europepmc.org/articles/PMC9112975/
Publikováno v:
Crit Rev Biochem Mol Biol
Although transcription by RNA polymerase (RNAP) is highly processive, elongation can be transiently halted by RNAP pausing. Pausing provides time for diverse regulatory events to occur such as RNA folding and regulatory factor binding. The transcript
Autor:
Paul Babitzke, Helen Yakhnin, Zachary F. Mandell, Alexander V. Yakhnin, Peter C. FitzGerald, Mikhail Kashlev, Carl E. Mcintosh, Maria L. Kireeva, Joshua Turek-Herman
Publikováno v:
Proceedings of the National Academy of Sciences. 117:21628-21636
Transcription is punctuated by RNA polymerase (RNAP) pausing. These pauses provide time for diverse regulatory events that can modulate gene expression. Transcription elongation factors dramatically affect RNAP pausing in vitro, but the genome-wide r
Autor:
Alexander V, Yakhnin, Peter C, FitzGerald, Carl, McIntosh, Helen, Yakhnin, Maria, Kireeva, Joshua, Turek-Herman, Zachary F, Mandell, Mikhail, Kashlev, Paul, Babitzke
Publikováno v:
Proc Natl Acad Sci U S A
Transcription is punctuated by RNA polymerase (RNAP) pausing. These pauses provide time for diverse regulatory events that can modulate gene expression. Transcription elongation factors dramatically affect RNAP pausing in vitro, but the genome-wide r
Autor:
Mikhail Kashlev, Alexander V. Yakhnin, Zachary F. Mandell, Reid T. Oshiro, Daniel B. Kearns, Paul Babitzke
NusA and NusG are transcription elongation factors that stimulate RNA polymerase pausing inBacillus subtilis. While NusA was known to function as an intrinsic termination factor, the role of NusG in this process had not been explored. To examine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ebb9757adb3c4ce7fa4ba2a0483ff75
https://doi.org/10.1101/2020.08.07.241513
https://doi.org/10.1101/2020.08.07.241513
Autor:
Mikhail Kashlev, Daniel B. Kearns, Paul Babitzke, Rishi K. Vishwakarma, Reid T. Oshiro, Zachary F. Mandell, Alexander V. Yakhnin
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the role of NusG in this process was unknown. To examine the indiv