Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Alexander V. Tuzikov"'
Autor:
Alexander M. Andrianov, Mikita A. Shuldau, Konstantin V. Furs, Artsemi M. Yushkevich, Alexander V. Tuzikov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8083 (2023)
Over the past three years, significant progress has been made in the development of novel promising drug candidates against COVID-19. However, SARS-CoV-2 mutations resulting in the emergence of new viral strains that can be resistant to the drugs use
Externí odkaz:
https://doaj.org/article/9112b600c1b94046a10a89af361a6b2d
Autor:
Alexander M. Andrianov, Grigory I. Nikolaev, Yuri V. Kornoushenko, Wei Xu, Shibo Jiang, Alexander V. Tuzikov
Publikováno v:
Viruses, Vol 11, Iss 8, p 746 (2019)
Despite recent progress in the development of novel potent HIV-1 entry/fusion inhibitors, there are currently no licensed antiviral drugs based on inhibiting the critical interactions of the HIV-1 envelope gp120 protein with cellular receptor CD4. In
Externí odkaz:
https://doaj.org/article/e73b3f7fb5fa45898cef164a60357346
Autor:
Nikita A. Shuldov, Arseny I. Anischenko, Grigory I. Nikolaev, Ivan P. Bosko, Alexander V. Tuzikov, Alexander M. Andrianov
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:7555-7573
A generative adversarial autoencoder for the rational design of potential HIV-1 entry inhibitors able to block CD4-binding site of the viral envelope protein gp120 was developed. To do this, the following studies were carried out: (i) an autoencoder
Autor:
Mikita A. Shuldau, Artsemi M. Yushkevich, Ivan P. Bosko, Alexander V. Tuzikov, Alexander M. Andrianov
Publikováno v:
Communications in Computer and Information Science ISBN: 9783030988821
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a8f3130d8efc23c48ed982f4be2d7c
https://doi.org/10.1007/978-3-030-98883-8_9
https://doi.org/10.1007/978-3-030-98883-8_9
Autor:
Yuri V. Kornoushenko, Anna D. Karpenko, Alexander M. Andrianov, Alexander V. Tuzikov, Ivan P. Bosko
Publikováno v:
Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics
A computational approach to in silico drug discovery was carried out to identify small druglike compounds able to show structural and functional mimicry of the high affinity ligand X77, potent non-covalent inhibitor of SARS-COV-2 main protease (MPro)
Publikováno v:
Doklady of the National Academy of Sciences of Belarus. 64:308-316
To find small-molecule compounds that can simulate the structural and functional properties of the high affinity X77 ligand of the main protease of SARS-CoV-2 - etiologic agent of COVID-19, the virtual screening of 9 molecular libraries of the Pharmi
Publikováno v:
Service Oriented Computing and Applications. 14:153-160
Based on evolutionary process optimization immune evolution algorithm, a multi-balloon cooperative control strategy is proposed, which targets at the problem that an artificial immune algorithm is apt to turn premature hastily when solving multi-obje
Publikováno v:
Informatika, Vol 17, Iss 2, Pp 44-53 (2020)
Structural prediction of protein-protein complexes has important application in such domains as modeling of biological processes and drug design. Homodimers (complexes which consist of two identical proteins) are the most common type of protein compl
Autor:
Ilya A. Vakser, Alexander V. Tuzikov, Ivan Anishchenko, A. Yu. Hadarovich, Petras J. Kundrotas
Publikováno v:
Doklady of the National Academy of Sciences of Belarus. 64:150-158
We propose an algorithm for comparing protein-protein complexes based on their functional properties in terms of Gene Ontology. The proposed measure of a functional similarity between complexes is combined with a structural measure to find templates
Autor:
Y.V. Kornoushenko, S. Jiang, G.I. Nikolaev, J. Huang, Alexander V. Tuzikov, Alexander M. Andrianov
Publikováno v:
Mathematical Biology and Bioinformatics. 14:430-449
Six potential peptidomimetics of the cross-reactive neutralizing anti-HIV-1 antibody N6 that are able to mimic the pharmacophoric features of this immunoglobulin by specific and effective interactions with the CD4-binding site of the viral gp120 prot