Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Alexander V. Mazin"'
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA damage that cause genomic instability that lead to cancer development. The highest fidelity pathway for repairing damaged double-stranded DNA is termed Homologous
Externí odkaz:
https://doaj.org/article/22dfb44279204a3e8ebf84451e384a14
Autor:
Katherine Sullivan-Reed, Elisabeth Bolton-Gillespie, Yashodhara Dasgupta, Samantha Langer, Micheal Siciliano, Margaret Nieborowska-Skorska, Kritika Hanamshet, Elizaveta A. Belyaeva, Andrea J. Bernhardy, Jaewong Lee, Morgan Moore, Huaqing Zhao, Peter Valent, Ksenia Matlawska-Wasowska, Markus Müschen, Smita Bhatia, Ravi Bhatia, Neil Johnson, Mariusz A. Wasik, Alexander V. Mazin, Tomasz Skorski
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3127-3136 (2018)
Summary: PARP inhibitors (PARPis) have been used to induce synthetic lethality in BRCA-deficient tumors in clinical trials with limited success. We hypothesized that RAD52-mediated DNA repair remains active in PARPi-treated BRCA-deficient tumor cells
Externí odkaz:
https://doaj.org/article/1a69e9155c374fdf8f71032c02246403
Autor:
Nadish Goyal, Matthew J. Rossi, Olga M. Mazina, Yong Chi, Robert L. Moritz, Bruce E. Clurman, Alexander V. Mazin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
RAD54 stimulates activity of the RAD51 recombinase and catalyzes branch migration of Holliday junctions during DNA repair and recombination. Here the authors show that the N-terminal domain of RAD54 mediates RAD54 oligomerization to promote branch mi
Externí odkaz:
https://doaj.org/article/b15bd6aeba5249c9abdcd8a19d96755d
Autor:
Alexander V. Mazin, Kritika Hanamshet
Publikováno v:
Nucleic Acids Research
RAD52 is a member of the homologous recombination pathway that is important for survival of BRCA-deficient cells. Inhibition of RAD52 leads to lethality in BRCA-deficient cells. However, the exact mechanism of how RAD52 contributes to viability of BR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95a1fb9f45552feadd5767add49cdf2
https://doi.org/10.1093/nar/gkaa1145
https://doi.org/10.1093/nar/gkaa1145
Publikováno v:
Genes
Volume 12
Issue 6
Genes, Vol 12, Iss 920, p 920 (2021)
Volume 12
Issue 6
Genes, Vol 12, Iss 920, p 920 (2021)
Targeting DNA repair proteins with small-molecule inhibitors became a proven anti-cancer strategy. Previously, we identified an inhibitor of a major protein of homologous recombination (HR) RAD51, named B02. B02 inhibited HR in human cells and sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306d9bd4621fd45fb01a850cd463575e
Autor:
Alexander V. Mazin, Olga M. Mazina
Publikováno v:
Homologous Recombination ISBN: 9781071606438
Methods Mol Biol
Methods Mol Biol
Rad54 is a eukaryotic protein that plays an important role in homologous recombination. Rad54, a member of the Swi2/Snf2 family, binds to Holliday junctions with high specificity and promotes their branch migration in an ATP hydrolysis-dependent mann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bae83a10ee1690186e9ab5a9f0f0193
https://doi.org/10.1007/978-1-0716-0644-5_11
https://doi.org/10.1007/978-1-0716-0644-5_11
Autor:
Andrey G. Baranovskiy, Tahir H. Tahirov, Farid A. Kadyrov, Lyudmila Y. Kadyrova, Alexander V. Mazin, Srinivas Somarowthu, Olga M. Mazina
Publikováno v:
J Biol Chem
Replication protein A (RPA), a major eukaryotic ssDNA-binding protein, is essential for all metabolic processes that involve ssDNA, including DNA replication, repair, and damage signaling. To perform its functions, RPA binds ssDNA tightly. In contras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef37093b994af6fd015b77ffb6ce690
https://doi.org/10.1101/2020.02.11.943977
https://doi.org/10.1101/2020.02.11.943977
Autor:
Gabor Banyai, Alli L. Gombolay, Chance Meers, Gary P. Newnam, Taehwan Yang, Havva Keskin, Alexander V. Mazin, Efiyenia I. Kaparos, Olga M. Mazina, Francesca Storici
Publikováno v:
SSRN Electronic Journal.
DNA double-strand breaks (DSBs) are dangerous lesions threatening genomic stability. Fidelity of DSB repair is best achieved by recombination with a homologous template sequence. In yeast, transcript RNA was shown to template DSB repair of chromosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c65a16744d49896cce682a6009599a0
https://doi.org/10.2139/ssrn.3517554
https://doi.org/10.2139/ssrn.3517554
Autor:
Kuntal Mukherjee, Chance Meers, Alli L. Gombolay, Francesca Storici, Gabor Banyai, Gary P. Newnam, Havva Keskin, Efiyenia I. Kaparos, Olga M. Mazina, Taehwan Yang, Alexander V. Mazin
Publikováno v:
Mol Cell
DNA double-stranded breaks (DSBs) are dangerous lesions threatening genomic stability. Fidelity of DSB repair is best achieved by recombination with a homologous template sequence. In yeast, transcript RNA was shown to template DSB repair of DNA. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ce6a381b69848a73f7428c25adef48
https://pubmed.ncbi.nlm.nih.gov/32882183
https://pubmed.ncbi.nlm.nih.gov/32882183
Autor:
Alexander V. Mazin, Nadish Goyal, Olga M. Mazina, Matthew J. Rossi, Bruce E. Clurman, Yong Chi, Robert L. Moritz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
In eukaryotes, RAD54 catalyzes branch migration (BM) of Holliday junctions, a basic process during DNA repair, replication, and recombination. RAD54 also stimulates RAD51 recombinase and has other activities. Here, we investigate the structural deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236c48f3a028bccec6cbf27ecd4b4a9f
http://link.springer.com/article/10.1038/s41467-017-02497-x
http://link.springer.com/article/10.1038/s41467-017-02497-x