Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alexander V. Kachur"'
Autor:
Alejandro D. Arroyo, Andrea E. Guzman, Alexander V. Kachur, Anatoliy V. Popov, E. James Delikatny
Publikováno v:
Frontiers in Physics, Vol 9 (2021)
This paper describes functional fluorinated bioactivatable molecules to study cancer metabolism using Cerenkov imaging. Resazurin (RA), or Alamar Blue, is a commonly used viability dye and redox sensor. Under reductive conditions or by the action of
Externí odkaz:
https://doaj.org/article/16978d1c68514c5a8c43b37b68526993
Autor:
Anatoliy V. Popov, Sarah J. Saylor, Alexander V. Kachur, Andrea E. Guzman, E. James Delikatny, Alejandro D. Arroyo
Publikováno v:
J Fluor Chem
In this paper, we report the synthesis and characterization of fluorinated derivatives of naphthofluorescein (NF), a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging. The compounds were prepared using electrophilic fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be49f42edb7ad67d823e21a174db4677
https://doi.org/10.1016/j.jfluchem.2019.05.010
https://doi.org/10.1016/j.jfluchem.2019.05.010
Autor:
Alexander V. Kachur, E. James Delikatny, Anatoliy V. Popov, Alejandro D. Arroyo, Sarah J. Saylor, Nikaela W. Bryan
Publikováno v:
Journal of Fluorine Chemistry. 200:146-152
Direct electrophilic fluorination using molecular fluorine gas is used in organic synthesis to create novel fluorine-containing compounds with potential beneficial activity that could not be obtained by nucleophilic substitution. In this paper, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c506f1fcefda50019f58cd65c55d50
https://doi.org/10.1016/j.jfluchem.2017.06.017
https://doi.org/10.1016/j.jfluchem.2017.06.017
Autor:
Alexander V. Kachur, Jason Driesbaugh, Stephen M. Hahn, Chaitanya R. Divgi, Kevin Judy, Cameron J. Koch, James B. Stubbs, D. Smith, Joel S. Karp, Joshua Scheuermann, Sydney M. Evans, Richard Freifelder, Janet S. Reddin, Susan Prendergast
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 37:2048-2059
The primary purpose of this study was to assess the biodistribution and radiation dose resulting from administration of (18)F-EF5, a lipophilic 2-nitroimidazole hypoxia marker in ten cancer patients. For three of these patients (with glioblastoma) un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72b7caab4ec446ff75e300fac76e42e
https://doi.org/10.1007/s00259-010-1517-y
https://doi.org/10.1007/s00259-010-1517-y
Publikováno v:
Applied Radiation and Isotopes. 68:293-296
Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, makin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe73e9537fc0e3a0f4a0f22f6da0d6e
https://doi.org/10.1016/j.apradiso.2009.10.005
https://doi.org/10.1016/j.apradiso.2009.10.005
Autor:
Anne L. Shuman, W. T. Jenkins, Cameron J. Koch, Richard Freifelder, William R. Dolbier, Sydney M. Evans, Joel S. Karp, Alexander V. Kachur
Publikováno v:
International Journal of Radiation Biology. 85:1137-1147
Tumour hypoxia affects cancer biology and therapy-resistance in both animals and humans. The purpose of this study was to determine whether EF5 ([2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide]) binding and/or radioactive dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f080cf4058c26c55aa46caafee78fa24
https://doi.org/10.3109/09553000903242172
https://doi.org/10.3109/09553000903242172
Autor:
John E. Biaglow, Alexander V. Kachur, Iraimoudi S. Ayene, Stephen W. Tuttle, Amit Maity, Patricia R. Oprysko, Cameron J. Koch
Publikováno v:
Journal of Biological Chemistry. 282:36790-36796
The oxidative pentose phosphate cycle (OPPC) is necessary to maintain cellular reducing capacity during periods of increased oxidative stress. Metabolic flux through the OPPC increases stoichiometrically in response to a broad range of chemical oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11fd3643e429371f14a2ab11bfde1909
https://doi.org/10.1074/jbc.m700327200
https://doi.org/10.1074/jbc.m700327200
Autor:
Sarah J. Saylor, E. James Delikatny, Alejandro D. Arroyo, Alexander V. Kachur, Anatoliy V. Popov
Publikováno v:
Journal of fluorine chemistry. 178
We present the synthesis and characterization of F18-labeled fluorinated derivatives of resazurin, a probe for cell viability. The compounds were prepared by direct fluorination of resazurin with diluted [F18]-F2 gas under acidic conditions. The fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2b262a1824f5ac437f093575ef39e4
https://pubmed.ncbi.nlm.nih.gov/26504251
https://pubmed.ncbi.nlm.nih.gov/26504251
Autor:
W. T. Jenkins, Chris Cardi, Shuman Al, Sydney M. Evans, Lisa S. Ziemer, Abass Alavi, Alexander V. Kachur, Joel S. Karp, Cameron J. Koch, William R. Dolbier
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 30:259-266
Tumor hypoxia is an important prognostic indicator for cancer therapy outcome. EF5 [2-(2-nitro-1[ H]-imidazol-1-yl)- N-(2,2,3,3,3-pentafluoropropyl)-acetamide] has been employed to measure tumor hypoxia in animals and humans using immunohistochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f255d21a488fb5b8ecbf9eea7f4113
https://doi.org/10.1007/s00259-002-1037-5
https://doi.org/10.1007/s00259-002-1037-5
Publikováno v:
Applied Radiation and Isotopes. 54:73-80
There is a great deal of clinical and experimental interest in determining tissue hypoxia using non-invasive imaging methods. We have developed EF5, 2-(2-nitro-1[H]-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide, with both invasive and non-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2d007a6e9acf0de882a65ae15ebec0
https://doi.org/10.1016/s0969-8043(00)00102-0
https://doi.org/10.1016/s0969-8043(00)00102-0