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Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles
Autor:
Alexander V. Ivanov, Alexei L. Zhuze, Sergey N. Kochetkov, Alexander V. Gromyko, Anna V. Mukovnya, Vera L. Tunitskaya, Alexander A. Ivanov, Strel'tsov Sa
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Dimeric bis-benzimidazoles ( DBn ) are the compounds specifically binding to A–T enriched sequences in the DNA minor groove. Due to this property they can inhibit DNA-dependent enzymes. We show that inhibition of the helicase activity of HCV NS3 pr