Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Alexander V. Alekseyenko"'
Publikováno v:
Genes, Vol 15, Iss 5, p 582 (2024)
High-dimensional biomedical datasets have become easier to collect in the last two decades with the advent of multi-omic and single-cell experiments. These can generate over 1000 measurements per sample or per cell. More recently, focus has been draw
Externí odkaz:
https://doaj.org/article/49017ae8e2114a1dac05791cc7b19df3
Autor:
Matthew D. Carson, Amy J. Warner, Jessica D. Hathaway-Schrader, Vincenza L. Geiser, Joseph Kim, Joy E. Gerasco, William D. Hill, John J. Lemasters, Alexander V. Alekseyenko, Yongren Wu, Hai Yao, J. Ignacio Aguirre, Caroline Westwater, Chad M. Novince
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Antibiotic-induced shifts in the indigenous gut microbiota influence normal skeletal maturation. Current theory implies that gut microbiota actions on bone occur through a direct gut/bone signaling axis. However, our prior work supports that a gut/li
Externí odkaz:
https://doaj.org/article/3d9af3f7271a4cf4a793aa66405e8d7f
Autor:
Nicola De Maio, Alexander V. Alekseyenko, William J. Coleman-Smith, Fabio Pardi, Marc A. Suchard, Asif U. Tamuri, Jakub Truszkowski, Nick Goldman
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Many important applications in bioinformatics, including sequence alignment and protein family profiling, employ sequence weighting schemes to mitigate the effects of non-independence of homologous sequences and under- or over-rep
Externí odkaz:
https://doaj.org/article/800e81744aa5473185abd18a8a0160c6
Autor:
Yongqun He, Haihe Wang, Jie Zheng, Daniel P. Beiting, Anna Maria Masci, Hong Yu, Kaiyong Liu, Jianmin Wu, Jeffrey L. Curtis, Barry Smith, Alexander V. Alekseyenko, Jihad S. Obeid
Publikováno v:
Journal of Biomedical Semantics, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background Host-microbiome interactions (HMIs) are critical for the modulation of biological processes and are associated with several diseases. Extensive HMI studies have generated large amounts of data. We propose that the logical represen
Externí odkaz:
https://doaj.org/article/f741cfba19274b27b9b0504b6bd064ff
Publikováno v:
Microbiome, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background Community-wide analyses provide an essential means for evaluation of the effect of interventions or design variables on the composition of the microbiome. Applications of these analyses are omnipresent in microbiome literature, ye
Externí odkaz:
https://doaj.org/article/da43338ecd9e49c9bd643fd882f6c154
Autor:
Zhenwu Luo, Min Li, Yongxia Wu, Zhefeng Meng, Lisa Martin, Lumin Zhang, Elizabeth Ogunrinde, Zejun Zhou, Shenghui Qin, Zhuang Wan, Maria Anna Julia Westerink, Stephanie Warth, Hui Liu, Ping Jin, David Stroncek, Quan-Zhen Li, Ena Wang, Xueling Wu, Sonya L. Heath, Zihai Li, Alexander V. Alekseyenko, Wei Jiang
Publikováno v:
Microbiome, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background Increased autoreactive antibodies have been reported in HIV disease; however, the mechanism accounting for autoantibody induction in HIV remains unknown. Results Herein, we show that seasonal influenza vaccination induces autoanti
Externí odkaz:
https://doaj.org/article/449377d5ac14496982dff9d66f66a81d
Autor:
Kristin Wallace, Georges J. Nahhas, Christine Bookhout, David N. Lewin, Chrystal M. Paulos, Nana Nikolaishvili-Feinberg, Stephanie M. Cohen, Silvia Guglietta, Ali Bakhtiari, E. Ramsay Camp, Elizabeth G. Hill, John A. Baron, Jennifer D. Wu, Alexander V. Alekseyenko
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundAfrican Americans (AAs) have higher colorectal cancer (CRC) incidence and mortality rate than Caucasian Americans (CAs). Recent studies suggest that immune responses within CRCs contribute to the disparities. If racially distinct immune sig
Externí odkaz:
https://doaj.org/article/13852281bd24419c90598ed39e511ab2
Autor:
M. Hanief Sofi, Yongxia Wu, Taylor Ticer, Steven Schutt, David Bastian, Hee-Jin Choi, Linlu Tian, Corey Mealer, Chen Liu, Caroline Westwater, Kent E. Armeson, Alexander V. Alekseyenko, Xue-Zhong Yu
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Graft-versus-host disease (GVHD) is a pathological process caused by an exaggerated donor lymphocyte response to host antigens after allogeneic hematopoietic cell transplantation (allo-HCT). Donor T cells undergo extensive clonal expansion and differ
Externí odkaz:
https://doaj.org/article/24cb8125c4bb4f71991982e1dbc3f3aa
Autor:
Zhenwu Luo, Alexander V. Alekseyenko, Elizabeth Ogunrinde, Min Li, Quan-Zhen Li, Lei Huang, Betty P. Tsao, Diane L. Kamen, Jim C. Oates, Zihai Li, Gary S. Gilkeson, Wei Jiang
Publikováno v:
Frontiers in Microbiology, Vol 11 (2021)
Blood microbiome is important to investigate microbial-host interactions and the effects on systemic immune perturbations. However, this effort has met with major challenges due to low microbial biomass and background artifacts. In the current study,
Externí odkaz:
https://doaj.org/article/89d071aa6a354071b293ab845a612355
Autor:
Xiaozhou Fan, Brandilyn A. Peters, Eric J. Jacobs, Susan M. Gapstur, Mark P. Purdue, Neal D. Freedman, Alexander V. Alekseyenko, Jing Wu, Liying Yang, Zhiheng Pei, Richard B. Hayes, Jiyoung Ahn
Publikováno v:
Microbiome, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background Dysbiosis of the oral microbiome can lead to local oral disease and potentially to cancers of the head, neck, and digestive tract. However, little is known regarding exogenous factors contributing to such microbial imbalance. Resu
Externí odkaz:
https://doaj.org/article/47281c5dd60e4a8f810573292e99a287