Výsledky vyhledávání - "Alexander V Vorotnikov"

Akademický článek

Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.

Autor: Pyotr A Tyurin-Kuzmin, Nadezhda D Zhdanovskaya, Anna A Sukhova, George D Sagaradze, Eugene A Albert, Ludmila V Ageeva, George V Sharonov, Alexander V Vorotnikov, Vsevolod A Tkachuk

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0154157 (2016)

Platelet derived growth factor (PDGF) orchestrates wound healing and tissue regeneration by regulating recruitment of the precursor mesenchymal stromal cells (MSC) and fibroblasts. PDGF stimulates generation of hydrogen peroxide that is required for

Externí odkaz: https://doaj.org/article/6456357aca3b4aed84dadb115361d437

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Akademický článek

Shear Stress and the AMP-Activated Protein Kinase Independently Protect the Vascular Endothelium from Palmitate Lipotoxicity

Autor: Asker Y. Khapchaev, Alexander V. Vorotnikov, Olga A. Antonova, Mikhail V. Samsonov, Ekaterina A. Shestakova, Igor A. Sklyanik, Alina O. Tomilova, Marina V. Shestakova, Vladimir P. Shirinsky

Publikováno v: Biomedicines, Vol 12, Iss 2, p 339 (2024)

Saturated free fatty acids are thought to play a critical role in metabolic disorders associated with obesity, insulin resistance, type 2 diabetes (T2D), and their vascular complications via effects on the vascular endothelium. The most abundant satu

Externí odkaz: https://doaj.org/article/74fba5b7fdda4627b2fa733ff34ce839

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Akademický článek

In Vitro Modeling of Diabetes Impact on Vascular Endothelium: Are Essentials Engaged to Tune Metabolism?

Autor: Alexander V. Vorotnikov, Asker Y. Khapchaev, Alexey V. Nickashin, Vladimir P. Shirinsky

Publikováno v: Biomedicines, Vol 10, Iss 12, p 3181 (2022)

Angiopathy is a common complication of diabetes mellitus. Vascular endothelium is among the first targets to experience blood-borne metabolic alterations, such as hyperglycemia and hyperlipidemia, the hallmarks of type 2 diabetes. To explore mechanis

Externí odkaz: https://doaj.org/article/e56bd77890d143a7a4178e3d87b96308

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Signaling and Gene Expression in Skeletal Muscles in Type 2 Diabetes: Current Results and OMICS Perspectives

Autor: Alexander V, Vorotnikov, Daniil V, Popov, Pavel A, Makhnovskii

Publikováno v: Biochemistry (Moscow). 87:1021-1034

Skeletal muscles mainly contribute to the emergence of insulin resistance, impaired glucose tolerance and the development of type 2 diabetes. Molecular mechanisms that regulate glucose uptake are diverse, including the insulin-dependent as most impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b214f7d26e90fa9579b2720e47fcc7d4
https://doi.org/10.1134/s0006297922090139

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Malondialdehyde but Not Methylglyoxal Impairs Insulin Signaling, NO Production, and Endothelial Barrier

Autor: Alexander V. Vorotnikov, M. V. Samsonov, V. Z. Lankin, V. P. Shirinsky, N. V. Podkuychenko

Publikováno v: Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 15:195-200

Dyslipidemia and hyperglycemia portray “cause-and-consequence” of type 2 diabetes mellitus (T2DM). They are linked to malondialdehyde (MDA) and methylglyoxal (MGO) generation that result from membrane lipid peroxidation and oxidative glucose conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4836e57d46206d295b071f72dcb9f60a
https://doi.org/10.1134/s1990747821030089

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AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess

Autor: Mikhail V. Samsonov, Nikita V. Podkuychenko, Asker Y. Khapchaev, Eugene E. Efremov, Elena V. Yanushevskaya, Tatiana N. Vlasik, Vadim Z. Lankin, Iurii S. Stafeev, Maxim V. Skulachev, Marina V. Shestakova, Alexander V. Vorotnikov, Vladimir P. Shirinsky

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 211, p 211 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 211

Hyperlipidemia manifested by high blood levels of free fatty acids (FFA) and lipoprotein triglycerides is critical for the progression of type 2 diabetes (T2D) and its cardiovascular complications via vascular endothelial dysfunction. However, attemp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13edb23b71e9a11846ff5f68dd469fba
http://europepmc.org/articles/PMC8745318

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Chemical Inducers of Obesity-Associated Metabolic Stress Activate Inflammation and Reduce Insulin Sensitivity in 3T3-L1 Adipocytes

Autor: N. Podkuychenko, S. Michurina, Ye. V. Parfyonova, I. S. Stafeev, Mikhail Menshikov, Alexander V. Vorotnikov

Publikováno v: Biochemistry (Moscow). 84:553-561

Obesity is accompanied by dyslipidemia, hypoxia, endoplasmic reticulum (ER) stress, and inflammation, representing the major risk factor for the development of insulin resistance (IR) and type 2 diabetes. We modeled these conditions in cultured 3T3-L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3777de267431fed50d058b5691a51e
https://doi.org/10.1134/s0006297919050092

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Low proliferative potential of adipose-derived stromal cells associates with hypertrophy and inflammation in subcutaneous and omental adipose tissue of patients with type 2 diabetes mellitus

Autor: S. Michurina, E. I. Ratner, Ekaterina A. Shestakova, N. Podkuychenko, Ye. V. Parfyonova, I. S. Stafeev, A. Panevina, Yuriy Ivanovich Yashkov, Marina Vladimirovna Shestakova, Mikhail Menshikov, V. Fedenko, Igor A. Sklyanik, Alexander V. Vorotnikov, Kamil Yahyaev

Publikováno v: Journal of Diabetes and its Complications. 33:148-159

Background Obesity and type 2 diabetes mellitus (T2DM) are among the most important morbidity factors. In this study we tested the hypothesis that low proliferative potential of adipose derived stromal cells (ADSC) associates with reduced formation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8878e2e0e542b99fb6a5cda59f9c081
https://doi.org/10.1016/j.jdiacomp.2018.10.011

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440-P: Dual Long-Term Effects of Free Fatty Acid on Human Endothelial Barrier In Vitro Are Mediated by NO, Mitochondrial ROS, and Dicarbonyl Stress

Autor: N. Podkuychenko, Marina Vladimirovna Shestakova, Asker Y. Khapchaev, Alexander V. Vorotnikov, Maxim Skulachev, Vladimir P. Shirinsky, Tatiana Vlasik, Vadim Z. Lankin, I. S. Stafeev, Mikhail V. Samsonov

Publikováno v: Diabetes. 70

In diabetes-associated hyperlipidemia, free fatty acids (FFAs) are thought to induce insulin resistance and endothelial dysfunction leading to vascular injury and cardiovascular T2DM complications. However, evidence is scarce regarding the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aea804be633fcddb15730a4c8621d9c
https://doi.org/10.2337/db21-440-p

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1147-P: Pseudo Insulin Resistance: Palmitate Inactivates Insulin Signaling but Stimulates Basal Glucose Uptake in 3T3-L1 Adipocytes

Autor: N. Podkuychenko, Asker Y. Khapchaev, Alexander V. Vorotnikov, I. S. Stafeev, Vladimir P. Shirinsky, S. Michurina

Publikováno v: Diabetes. 70

Increased levels of circulating free fatty acids (FFA) is the major risk factor for type 2 diabetes in obesity. While the long-term effects of increased FFA on adipose tissue likely involve latent inflammation, the short-term effects on insulin-sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66ded2252a4331dcf58a8ebe17848527
https://doi.org/10.2337/db21-1147-p

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