Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Alexander V Kolesnikov"'
Autor:
Alexander V Kolesnikov, Elena Lobysheva, Jaya P Gnana-Prakasam, Vladimir J Kefalov, Oleg G Kisselev
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272506 (2022)
Heterotrimeric G-protein transducin, Gt, is a key signal transducer and amplifier in retinal rod and cone photoreceptor cells. Despite similar subunit composition, close amino acid identity, and identical posttranslational farnesylation of their Gγ
Externí odkaz:
https://doaj.org/article/d0d2dc06ee6c41a093dbf3437119202b
Autor:
Henri Leinonen, Jianye Zhang, Laurence M. Occelli, Umair Seemab, Elliot H. Choi, Luis Felipe L.P. Marinho, Janice Querubin, Alexander V. Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T. Lee, Elliott E. Einstein, David E. Einstein, Zhiqian Dong, Philip D. Kiser, Seth Blackshaw, Vladimir J. Kefalov, Marcin Tabaka, Andrzej Foik, Simon M. Petersen-Jones, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations
Externí odkaz:
https://doaj.org/article/b5b9cf370c114fd1b6b378a34d01cbf7
Autor:
Ignacio Sarria, Johan Pahlberg, Yan Cao, Alexander V Kolesnikov, Vladimir J Kefalov, Alapakkam P Sampath, Kirill A Martemyanov
Publikováno v:
eLife, Vol 4 (2015)
In the retina, synaptic transmission between photoreceptors and downstream ON-bipolar neurons (ON-BCs) is mediated by a GPCR pathway, which plays an essential role in vision. However, the mechanisms that control signal transmission at this synapse an
Externí odkaz:
https://doaj.org/article/d01bfcc050624712a2ad7719991c9db8
Autor:
Christopher M Tracy, Alexander V Kolesnikov, Devon R Blake, Ching-Kang Chen, Wolfgang Baehr, Vladimir J Kefalov, Barry M Willardson
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117129 (2015)
G protein β subunits (Gβ) play essential roles in phototransduction as part of G protein βγ (Gβγ) and regulator of G protein signaling 9 (RGS9)-Gβ5 heterodimers. Both are obligate dimers that rely on the cytosolic chaperone CCT and its co-chap
Externí odkaz:
https://doaj.org/article/41dd7572ce18406d9175fa0dc4ac2c64
Autor:
Marco Bassetto, Alexander V. Kolesnikov, Dominik Lewandowski, Jianying Z. Kiser, Maximilian Halabi, David E. Einstein, Elliot H. Choi, Krzysztof Palczewski, Vladimir J. Kefalov, Philip D. Kiser
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114143- (2024)
Summary: Cellular retinaldehyde-binding protein (CRALBP) supports production of 11-cis-retinaldehyde and its delivery to photoreceptors. It is found in the retinal pigment epithelium (RPE) and Müller glia (MG), but the relative functional importance
Externí odkaz:
https://doaj.org/article/536a6d5ec23043fcb00d03661c34c961
Autor:
Matthew D Cain, Bradly Q Vo, Alexander V Kolesnikov, Vladimir J Kefalov, Susan M Culican, Daniel Kerschensteiner, Kendall J Blumer
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82276 (2013)
In the outer retina, G protein-coupled receptor (GPCR) signaling mediates phototransduction and synaptic transmission between photoreceptors and ON bipolar cells. In contrast, the functions of modulatory GPCR signaling networks in the inner retina ar
Externí odkaz:
https://doaj.org/article/870735496677482fbf34c64d6ee928fc
Autor:
Aleksander Tworak, Alexander V. Kolesnikov, John D. Hong, Elliot H. Choi, Jennings C. Luu, Grazyna Palczewska, Zhiqian Dong, Dominik Lewandowski, Matthew J. Brooks, Laura Campello, Anand Swaroop, Philip D. Kiser, Vladimir J. Kefalov, Krzysztof Palczewski
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112982- (2023)
Summary: In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor (RGR) photoisomerase, which is expressed in both the
Externí odkaz:
https://doaj.org/article/d81d281593bd407d80bcbeef11c89b36
Autor:
Amine M. Laradji, Alexander V. Kolesnikov, Bedia B. Karakoçak, Vladimir J. Kefalov, Nathan Ravi
Publikováno v:
ACS Omega, Vol 6, Iss 9, Pp 6172-6184 (2021)
Externí odkaz:
https://doaj.org/article/c342168d384c41428c738f04837cea7f
Publikováno v:
Конденсированные среды и межфазные границы, Vol 23, Iss 2 (2021)
The production technology of hydrometallurgical zinc uses various surfactants to thicken pulps, stabilise the electrolysis process, and obtain high-quality cathode deposits. Numerous researches were conducted to study the cathodic and anodic processe
Externí odkaz:
https://doaj.org/article/86d9a3d0be9c4903adb634728800181f
Autor:
Christina Thebeau, Sheng Zhang, Alexander V. Kolesnikov, Vladimir J. Kefalov, Clay F. Semenkovich, Rithwick Rajagopal
Publikováno v:
Neurobiology of Disease, Vol 137, Iss , Pp 104754- (2020)
Illumination of the retina is a major determinant of energy expenditure by its neurons. However, it remains unclear whether light exposure significantly contributes to the pathophysiology of common retinal disease. Driven by the premise that light ex
Externí odkaz:
https://doaj.org/article/013ba5cee34d4c6785695d78afaea57c