Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Alexander V Gourine"'
Autor:
Svetlana Mastitskaya, Marina Basalay, Patrick S Hosford, Andrew G Ramage, Andrey Gourine, Alexander V Gourine
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150108 (2016)
Signalling pathways underlying the phenomenon of remote ischaemic preconditioning (RPc) cardioprotection are not completely understood. The existing evidence agrees that intact sensory innervation of the remote tissue/organ is required for the releas
Externí odkaz:
https://doaj.org/article/297d410ef6e74977b29a5ded5496331a
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167861 (2016)
Complex mechanisms that detect changes in brainstem parenchymal PCO2/[H+] and trigger adaptive changes in lung ventilation are responsible for central respiratory CO2 chemosensitivity. Previous studies of chemosensory signalling pathways suggest that
Externí odkaz:
https://doaj.org/article/26e68be5286b43348b78d8a889c6c7b4
Autor:
Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113514- (2023)
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen
Externí odkaz:
https://doaj.org/article/e103ac5e3e2a45a0b6df0577e2df1764
Autor:
Olga Kopach, Sergyi Sylantyev, Lucie Bard, Piotr Michaluk, Janosch P. Heller, Ana Gutierrez del Arroyo, Gareth L. Ackland, Alexander V. Gourine, Dmitri A. Rusakov
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107236- (2023)
Summary: Neutrophils are white blood cells that are critical to acute inflammatory and adaptive immune responses. Their swarming-pattern behavior is controlled by multiple cellular cascades involving calcium-dependent release of various signaling mol
Externí odkaz:
https://doaj.org/article/e29399bbfa284d4aac50d5a7106fd7e9
Autor:
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Iván Ruminot, Mark F. Lythgoe, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The mechanism of neurovascular coupling ensures that the brain energy supply is sufficient to meet demand. Here the authors show that in this mechanism CO2 plays an important role in neuronal activity-dependent regulation of local brain blood flow.
Externí odkaz:
https://doaj.org/article/0e7fd82c54eb4eecb447c0bf5d5c893f
Autor:
Anna Hadjihambi, Cristina Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Chris Donnelly, Christos Konstantinou, Nathan Davies, Abeba Habtesion, Alexander V. Gourine, Rajiv Jalan, Patrick S. Hosford
Publikováno v:
JHEP Reports, Vol 4, Iss 8, Pp 100509- (2022)
Background & Aims: Increased plasma ammonia concentration and consequent disruption of brain energy metabolism could underpin the pathogenesis of hepatic encephalopathy (HE). Brain energy homeostasis relies on effective maintenance of brain oxygenati
Externí odkaz:
https://doaj.org/article/61b571bae53140f4bb2037e851d603c1
Autor:
Lindsea C. Booth, Song T. Yao, Alla Korsak, David G.S. Farmer, Sally G. Hood, Daniel McCormick, Quinn Boesley, Angela A. Connelly, Stuart J. McDougall, Willian S. Korim, Sarah-Jane Guild, Svetlana Mastitskaya, Phuong Le, Anja G. Teschemacher, Sergey Kasparov, Gareth L. Ackland, Simon C. Malpas, Robin M. McAllen, Andrew M. Allen, Clive N. May, Alexander V. Gourine
Publikováno v:
Brain Stimulation, Vol 14, Iss 1, Pp 88-96 (2021)
Background: Electrical stimulation applied to individual organs, peripheral nerves, or specific brain regions has been used to treat a range of medical conditions. In cardiovascular disease, autonomic dysfunction contributes to the disease progressio
Externí odkaz:
https://doaj.org/article/03a4bef93ac24e2d8772b644715a7a34
Autor:
Shaun M. May, Eric Chiang, Anna Reyes, Gladys Martir, Amour Patel, Shamir Karmali, Sanjiv Patel, Simeon West, Ana Gutierrez del Arroyo, Alexander V. Gourine, Gareth L. Ackland
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 16, Iss , Pp 100299- (2021)
Experimental animal studies on the mechanisms of remote ischaemic conditioning (RIC)-induced cardioprotection against ischaemia/reperfusion injury demonstrate involvement of both neuronal and humoral pathways. Autonomic parasympathetic (vagal) pathwa
Externí odkaz:
https://doaj.org/article/75333d07cbf14780a443e165a528e261
Autor:
Afnan Saleh Al-Menhali, Cali Anderson, Alexander V. Gourine, Andrey Y. Abramov, Alicia D’Souza, Morana Jaganjac
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Regular exercise has many health benefits, among which is a significant reduction of cardiovascular risk. Although many beneficial effects of exercise are well described, the exact mechanisms by which exercise confers cardiovascular benefits are yet
Externí odkaz:
https://doaj.org/article/977e44b359d248b797ef21a575de3086
Autor:
Adam D. Farmer, Adam Strzelczyk, Alessandra Finisguerra, Alexander V. Gourine, Alireza Gharabaghi, Alkomiet Hasan, Andreas M. Burger, Andrés M. Jaramillo, Ann Mertens, Arshad Majid, Bart Verkuil, Bashar W. Badran, Carlos Ventura-Bort, Charly Gaul, Christian Beste, Christopher M. Warren, Daniel S. Quintana, Dorothea Hämmerer, Elena Freri, Eleni Frangos, Eleonora Tobaldini, Eugenijus Kaniusas, Felix Rosenow, Fioravante Capone, Fivos Panetsos, Gareth L. Ackland, Gaurav Kaithwas, Georgia H. O'Leary, Hannah Genheimer, Heidi I. L. Jacobs, Ilse Van Diest, Jean Schoenen, Jessica Redgrave, Jiliang Fang, Jim Deuchars, Jozsef C. Széles, Julian F. Thayer, Kaushik More, Kristl Vonck, Laura Steenbergen, Lauro C. Vianna, Lisa M. McTeague, Mareike Ludwig, Maria G. Veldhuizen, Marijke De Couck, Marina Casazza, Marius Keute, Marom Bikson, Marta Andreatta, Martina D'Agostini, Mathias Weymar, Matthew Betts, Matthias Prigge, Michael Kaess, Michael Roden, Michelle Thai, Nathaniel M. Schuster, Nicola Montano, Niels Hansen, Nils B. Kroemer, Peijing Rong, Rico Fischer, Robert H. Howland, Roberta Sclocco, Roberta Sellaro, Ronald G. Garcia, Sebastian Bauer, Sofiya Gancheva, Stavros Stavrakis, Stefan Kampusch, Susan A. Deuchars, Sven Wehner, Sylvain Laborde, Taras Usichenko, Thomas Polak, Tino Zaehle, Uirassu Borges, Vanessa Teckentrup, Vera K. Jandackova, Vitaly Napadow, Julian Koenig
Publikováno v:
Frontiers in Human Neuroscience, Vol 14 (2021)
Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular bra
Externí odkaz:
https://doaj.org/article/559b65cb001b4e368330a755e0899b33