Effect of differentiation, de novo innervation, and electrical pulse stimulation on mRNA and protein expression of Na+,K+-ATPase, FXYD1, and FXYD5 in cultured human skeletal muscle cells.

Autor: Vid Jan, Katarina Miš, Natasa Nikolic, Klemen Dolinar, Metka Petrič, Andraž Bone, G Hege Thoresen, Arild C Rustan, Tomaž Marš, Alexander V Chibalin, Sergej Pirkmajer

Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0247377 (2021)

Denervation reduces the abundance of Na+,K+-ATPase (NKA) in skeletal muscle, while reinnervation increases it. Primary human skeletal muscle cells, the most widely used model to study human skeletal muscle in vitro, are usually cultured as myoblasts

Externí odkaz: https://doaj.org/article/a8f175e2aba742e0836f3151d97ecc8f

Short-term intensified cycle training alters acute and chronic responses of PGC1α and Cytochrome C oxidase IV to exercise in human skeletal muscle.

Autor: Nigel K Stepto, Boubacar Benziane, Glenn D Wadley, Alexander V Chibalin, Benedict J Canny, Nir Eynon, Glenn K McConell

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e53080 (2012)

Reduced activation of exercise responsive signalling pathways have been reported in response to acute exercise after training; however little is known about the adaptive responses of the mitochondria. Accordingly, we investigated changes in mitochond

Externí odkaz: https://doaj.org/article/246bf7d12be443f2956e865937a6021e

Editorial: Untangling energy metabolism in skeletal muscle: From physiology to pharmacology

Autor: Sergej Pirkmajer, Pablo M. Garcia-Roves, Arild C. Rustan, Alexander V. Chibalin

Publikováno v: Frontiers in Physiology. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c335f6e4bf26db1dd033c45845c566

Discovery of thymosin β4 as a human exerkine and growth factor

Autor: Marie Björnholm, Jonas T. Treebak, Atul S. Deshmukh, Niklas Rye Jørgensen, Christoffer Clemmensen, Anna Krook, Alba Gonzalez-Franquesa, Juleen R. Zierath, Emilie Dalbram, Håkan Karlsson, Stanislava Pankratova, Ben Stocks, Morten Hostrup, Sevda Gheibi, Alexander V. Chibalin, Ankita Agrawal, Thomas Nielsen, Melissa L. Borg, Michael S. Kuefner

Publikováno v: Gonzalez-Franquesa, A, Stocks, B, Borg, M L, Kuefner, M, Dalbram, E, Nielsen, T S, Agrawal, A, Pankratova, S, Chibalin, A V, Karlsson, H K R, Gheibi, S, Björnholm, M, Jørgensen, N R, Clemmensen, C, Treebak, J T, Hostrup, M, Krook, A, Zierath, J R & Deshmukh, A S 2021, ' Discovery of thymosin β4 as a human exerkine and growth factor ', American Journal of Physiology: Cell Physiology, vol. 321, no. 5, pp. C770-C778 . https://doi.org/10.1152/ajpcell.00263.2021

Skeletal muscle is an endocrine organ secreting exercise-induced factors (exerkines), which play a pivotal role in interorgan cross talk. Using mass spectrometry (MS)-based proteomics, we characterized the secretome and identified thymosin β4 (TMSB4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31fd3fee8e53e53d49591be8655c1af
https://doi.org/10.1152/ajpcell.00263.2021

Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers

Autor: Nicolas J, Pillon, Laura, Sardón Puig, Ali, Altıntaş, Prasad G, Kamble, Salvador, Casaní-Galdón, Brendan M, Gabriel, Romain, Barrès, Ana, Conesa, Alexander V, Chibalin, Erik, Näslund, Anna, Krook, Juleen R, Zierath

Publikováno v: Life science alliance. 6(1)

Obesity and elevated circulating lipids may impair metabolism by disrupting the molecular circadian clock. We tested the hypothesis that lipid overload may interact with the circadian clock and alter the rhythmicity of gene expression through epigeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef0883d12825d9c5f6da9a1bd8c683cf
https://pubmed.ncbi.nlm.nih.gov/36302651