Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alexander V, Vorotnikov"'
Autor:
Asker Y. Khapchaev, Alexander V. Vorotnikov, Olga A. Antonova, Mikhail V. Samsonov, Ekaterina A. Shestakova, Igor A. Sklyanik, Alina O. Tomilova, Marina V. Shestakova, Vladimir P. Shirinsky
Publikováno v:
Biomedicines, Vol 12, Iss 2, p 339 (2024)
Saturated free fatty acids are thought to play a critical role in metabolic disorders associated with obesity, insulin resistance, type 2 diabetes (T2D), and their vascular complications via effects on the vascular endothelium. The most abundant satu
Externí odkaz:
https://doaj.org/article/74fba5b7fdda4627b2fa733ff34ce839
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3181 (2022)
Angiopathy is a common complication of diabetes mellitus. Vascular endothelium is among the first targets to experience blood-borne metabolic alterations, such as hyperglycemia and hyperlipidemia, the hallmarks of type 2 diabetes. To explore mechanis
Externí odkaz:
https://doaj.org/article/e56bd77890d143a7a4178e3d87b96308
Autor:
Mikhail V. Samsonov, Nikita V. Podkuychenko, Asker Y. Khapchaev, Eugene E. Efremov, Elena V. Yanushevskaya, Tatiana N. Vlasik, Vadim Z. Lankin, Iurii S. Stafeev, Maxim V. Skulachev, Marina V. Shestakova, Alexander V. Vorotnikov, Vladimir P. Shirinsky
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 211 (2021)
Hyperlipidemia manifested by high blood levels of free fatty acids (FFA) and lipoprotein triglycerides is critical for the progression of type 2 diabetes (T2D) and its cardiovascular complications via vascular endothelial dysfunction. However, attemp
Externí odkaz:
https://doaj.org/article/a7d61f60f00141f084647cebcdcb2eb7
Publikováno v:
Biochemistry (Moscow). 87:1021-1034
Skeletal muscles mainly contribute to the emergence of insulin resistance, impaired glucose tolerance and the development of type 2 diabetes. Molecular mechanisms that regulate glucose uptake are diverse, including the insulin-dependent as most impor
Autor:
Dina K. Gaynullina, Tatiana V. Kudryashova, Alexander V. Vorotnikov, Rudolf Schubert, Olga S. Tarasova
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6037 (2021)
Previously, the abundance of p42/44 and p38 MAPK proteins had been shown to be higher in arteries of 1- to 2-week-old compared to 2- to 3-month-old rats. However, the role of MAPKs in vascular tone regulation in early ontogenesis remains largely unex
Externí odkaz:
https://doaj.org/article/0bbc7a80728344ec9e07c66f5397e52e
Publikováno v:
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology. 15:195-200
Dyslipidemia and hyperglycemia portray “cause-and-consequence” of type 2 diabetes mellitus (T2DM). They are linked to malondialdehyde (MDA) and methylglyoxal (MGO) generation that result from membrane lipid peroxidation and oxidative glucose conv
Autor:
Pyotr A Tyurin-Kuzmin, Nadezhda D Zhdanovskaya, Anna A Sukhova, George D Sagaradze, Eugene A Albert, Ludmila V Ageeva, George V Sharonov, Alexander V Vorotnikov, Vsevolod A Tkachuk
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154157 (2016)
Platelet derived growth factor (PDGF) orchestrates wound healing and tissue regeneration by regulating recruitment of the precursor mesenchymal stromal cells (MSC) and fibroblasts. PDGF stimulates generation of hydrogen peroxide that is required for
Externí odkaz:
https://doaj.org/article/6456357aca3b4aed84dadb115361d437
Autor:
N. Podkuychenko, Marina Vladimirovna Shestakova, Asker Y. Khapchaev, Alexander V. Vorotnikov, Maxim Skulachev, Vladimir P. Shirinsky, Tatiana Vlasik, Vadim Z. Lankin, I. S. Stafeev, Mikhail V. Samsonov
Publikováno v:
Diabetes. 70
In diabetes-associated hyperlipidemia, free fatty acids (FFAs) are thought to induce insulin resistance and endothelial dysfunction leading to vascular injury and cardiovascular T2DM complications. However, evidence is scarce regarding the effects of
Autor:
N. Podkuychenko, Asker Y. Khapchaev, Alexander V. Vorotnikov, I. S. Stafeev, Vladimir P. Shirinsky, S. Michurina
Publikováno v:
Diabetes. 70
Increased levels of circulating free fatty acids (FFA) is the major risk factor for type 2 diabetes in obesity. While the long-term effects of increased FFA on adipose tissue likely involve latent inflammation, the short-term effects on insulin-sensi
Autor:
E. I. Ratner, Anatoliy Yurasov, Yelena V. Parfyonova, Marina Vladimirovna Shestakova, Ekaterina A. Shestakova, I. S. Stafeev, Kamil Yahyaev, Mikhail Menshikov, Igor A. Sklyanik, Alexander V. Vorotnikov, S. Michurina, E. Mamontova
Publikováno v:
Diabetes. 70
Objective: We have performed the comparative study of basal state of SGK-dependent signaling among obese patients with/without type 2 diabetes mellitus (T2DM). We have accomplished correlation analysis of glucose metabolism and incretin profile param