Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Alexander V, Statsyuk"'
Autor:
Shifali Shishodia, Stefan G. Kathman, Daniel J. Sprague, Michael D. Olp, Steven B. Summers, Brian C. Smith, Sarah L. Wynia-Smith, Alexander V. Statsyuk, Ziyang Xu, Christopher J. Goetz
Publikováno v:
ACS Chem Biol
BRD4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All reported BET family ligands bind within the bromodomain acetyl-lysine binding sites and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111cdce31441bd146ee60cd2e125cc11
https://doi.org/10.1021/acschembio.0c00058
https://doi.org/10.1021/acschembio.0c00058
Autor:
Alexander V. Statsyuk
Publikováno v:
Science. 376:1049-1050
Covalent prodrugs inhibit protein synthesis targets killing parasites but not human cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5483f022c8b2be60c81f1ceb5379901f
https://doi.org/10.1126/science.abq4457
https://doi.org/10.1126/science.abq4457
Publikováno v:
Journal of Biological Chemistry. 292:16539-16553
Ring-between-ring (RBR) E3 ligases have been implicated in autoimmune disorders and neurodegenerative diseases. The functions of many RBR E3s are poorly defined, and their regulation is complex, involving post-translational modifications and alloster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59f2e9dff1ceb54eca59a760d38baa1
https://doi.org/10.1074/jbc.m116.773200
https://doi.org/10.1074/jbc.m116.773200
Publikováno v:
Current Protocols in Chemical Biology. 9:174-195
HECT E3 ubiquitin ligases are responsible for many human disease phenotypes and are promising drug targets; however, screening assays for HECT E3 inhibitors are inherently complex, requiring upstream E1 and E2 enzymes as well as ubiquitin, ATP, and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12617205ec4a3871d10267fd03d33da2
https://doi.org/10.1002/cpch.24
https://doi.org/10.1002/cpch.24
Publikováno v:
Current Protocols in Chemical Biology
HECT E3 ubiquitin ligases (∼28 are known) are associated with many phenotypes in eukaryotes and are important drug targets. However, assays used to screen for small molecule inhibitors of HECT E3s are complex and require ATP, Ub, E1, E2, and HECT E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a45036b5e89795fc3350c2663c311c96
https://doi.org/10.1002/cpch.17
https://doi.org/10.1002/cpch.17
Autor:
David T. Krist, Benjamin W. Parker, Eric L. Weiss, Edward J. Goncz, Alexey I. Nesvizhskii, Alexander V. Statsyuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(42)
Short linear peptide motifs that are intracellular ligands of folded proteins are a modular, incompletely understood molecular interaction language in signaling systems. Such motifs, which frequently occur in intrinsically disordered protein regions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8ba7ca084db678192b1ea8a7c83af4
https://pubmed.ncbi.nlm.nih.gov/31578253
https://pubmed.ncbi.nlm.nih.gov/31578253
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1967
Covalent fragments are an emerging technology to discover covalent ligands in target-based or phenotypic screens. Here we describe screening of cysteine-reactive covalent fragments against a protein of interest using mass spectrometry or enzymatic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0434a47a890cb133f9831c5e05add4a
https://pubmed.ncbi.nlm.nih.gov/31069775
https://pubmed.ncbi.nlm.nih.gov/31069775
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991860
Covalent fragments are an emerging technology to discover covalent ligands in target-based or phenotypic screens. Here we describe screening of cysteine-reactive covalent fragments against a protein of interest using mass spectrometry or enzymatic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7d19cedecf859a35d48023346473099
https://doi.org/10.1007/978-1-4939-9187-7_15
https://doi.org/10.1007/978-1-4939-9187-7_15
Publikováno v:
MedChemComm. 7:576-585
Covalent probes and drugs have found widespread use as research tools and clinical agents. Covalent probes are useful because of their increased intracellular potency and because covalent labeling of cellular proteins can be tracked using click chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1a3ca462a9370e8fd708f05c9c5234
https://doi.org/10.1039/c5md00518c
https://doi.org/10.1039/c5md00518c
Autor:
Steven Kennedy, Patrick Chuong, Sandipan Roy Chowdhury, Stefan G. Kathman, Alexander V. Statsyuk, Alyssa uyen Nguyen, Kai Zhu, Rama K. Mishra
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(1)
Here we present a virtual docking screen of 1648 commercially available covalent fragments, and identified covalent inhibitors of cysteine protease cathepsin L. These inhibitors did not inhibit closely related protease cathepsin B. Thus, we have esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b47970aa85fa539530ec3c3cf0093e7
https://pubmed.ncbi.nlm.nih.gov/30455147
https://pubmed.ncbi.nlm.nih.gov/30455147