Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Alexander Titz"'
Autor:
Elena Shanina, Sakonwan Kuhaudomlarp, Eike Siebs, Felix F. Fuchsberger, Maxime Denis, Priscila da Silva Figueiredo Celestino Gomes, Mads H. Clausen, Peter H. Seeberger, Didier Rognan, Alexander Titz, Anne Imberty, Christoph Rademacher
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)
Carbohydrate–protein interactions are key for cell–cell and host–pathogen recognition, but their hydrophilic nature makes the development of drug-like inhibitors a challenge. Here, screening of fragment libraries identifies metal-binding pharma
Externí odkaz:
https://doaj.org/article/4b306191f31141ed861dba296acb045e
Autor:
David C. B. Siebert, Roman Sommer, Domen Pogorevc, Michael Hoffmann, Silke C. Wenzel, Rolf Müller, Alexander Titz
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2922-2929 (2019)
The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis. Mutasynthesis is a promi
Externí odkaz:
https://doaj.org/article/7b6c682e0adb4e48a02cbe71b43e090e
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2607-2617 (2018)
The rapid development of antimicrobial resistance is threatening mankind to such an extent that the World Health Organization expects more deaths from infections than from cancer in 2050 if current trends continue. To avoid this scenario, new classes
Externí odkaz:
https://doaj.org/article/174a1e34626146cca24368047e57b498
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2631-2636 (2017)
A novel synthesis of 1,6-anhydro-N-acetylmuramic acid is described, which proceeds in only five steps from the cheap starting material N-acetylglucosamine. This efficient synthesis should enable future studies into the importance of 1,6-anhydromurami
Externí odkaz:
https://doaj.org/article/a383a007b3394b7fa7438dc8f3bc4de9
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2828-2833 (2016)
Selenoglycosides are used as reactive glycosyl donors in the syntheses of oligosaccharides. In addition, such heavy atom analogs of natural glycosides are useful tools for structure determination of their lectin receptors using X-ray crystallography.
Externí odkaz:
https://doaj.org/article/1835684b1fa1439680772695275b4166
Autor:
Isabel Hottmann, Valentina M. T. Mayer, Markus B. Tomek, Valentin Friedrich, Matthew B. Calvert, Alexander Titz, Christina Schäffer, Christoph Mayer
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Tannerella forsythia is an anaerobic, Gram-negative oral pathogen that thrives in multispecies gingival biofilms associated with periodontitis. The bacterium is auxotrophic for the commonly essential bacterial cell wall sugar N-acetylmuramic acid (Mu
Externí odkaz:
https://doaj.org/article/c1ad03f035874cc2b3fa05440bbe2b1f
Autor:
Joao A Rodrigues, Alvaro Acosta-Serrano, Markus Aebi, Michael A J Ferguson, Françoise H Routier, Irene Schiller, Simão Soares, Daniel Spencer, Alexander Titz, Iain B H Wilson, Luis Izquierdo
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005169 (2015)
Externí odkaz:
https://doaj.org/article/c0085006c08b41e19aba1a772fc8b837
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112822 (2014)
The rise of resistances against antibiotics in bacteria is a major threat for public health and demands the development of novel antibacterial therapies. Infections with Pseudomonas aeruginosa are a severe problem for hospitalized patients and for pa
Externí odkaz:
https://doaj.org/article/942a614f8b4d4aefa5c679bcc3946008
Publikováno v:
CHIMIA, Vol 67, Iss 4 (2013)
Hospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new ther
Externí odkaz:
https://doaj.org/article/16498d03a466419d8f9ecdb1d0e1697a
Autor:
Alex Butschi, Alexander Titz, Martin A Wälti, Vincent Olieric, Katharina Paschinger, Katharina Nöbauer, Xiaoqiang Guo, Peter H Seeberger, Iain B H Wilson, Markus Aebi, Michael O Hengartner, Markus Künzler
Publikováno v:
PLoS Pathogens, Vol 6, Iss 1, p e1000717 (2010)
The physiological role of fungal galectins has remained elusive. Here, we show that feeding of a mushroom galectin, Coprinopsis cinerea CGL2, to Caenorhabditis elegans inhibited development and reproduction and ultimately resulted in killing of this
Externí odkaz:
https://doaj.org/article/9436674aad2740f085e0ecbf4461a06c