Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Alexander Tarakhovsky"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionTranscriptional activation depends on the interplay of chromatin modifiers to establish a permissive epigenetic landscape. While histone 3 lysine 9 (H3K9) methylation has long been associated with gene repression, there is limited evidenc
Externí odkaz:
https://doaj.org/article/8a9e16423c1846cda7919d6e7e9aaaae
Autor:
Vera M Ruda, Rohit Chandwani, Alfica Sehgal, Roman L Bogorad, Akin Akinc, Klaus Charisse, Alexander Tarakhovsky, Tatiana I Novobrantseva, Victor Koteliansky
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101749 (2014)
Argonaute 2 (Ago2) is the only mammalian Ago protein capable of mRNA cleavage. It has been reported that the activity of the short interfering RNA targeting coding sequence (CDS), but not 3' untranslated region (3'UTR) of an mRNA, is solely dependent
Externí odkaz:
https://doaj.org/article/944eb249cdc14faba263d18f526c0dbb
Autor:
Therese Andersson, Sabhi Rahman, Stephen N Sansom, Jessica M Alsiö, Masahiro Kaneda, James Smith, Donal O'Carroll, Alexander Tarakhovsky, Frederick J Livesey
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13453 (2010)
To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all mi
Externí odkaz:
https://doaj.org/article/3a56cd386e65468bb48c5eae610ec0ef
Autor:
Katsuhiko Hayashi, Susana M Chuva de Sousa Lopes, Masahiro Kaneda, Fuchou Tang, Petra Hajkova, Kaiqin Lao, Donal O'Carroll, Partha P Das, Alexander Tarakhovsky, Eric A Miska, M Azim Surani
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1738 (2008)
MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells express another type of small RNA, pi
Externí odkaz:
https://doaj.org/article/4f7156a2b7a54ca091906d11f8333c33
Transcriptional activation depends on the interplay of chromatin modifiers to establish a permissive epigenetic landscape. While histone 3 lysine 9 (H3K9) methylation has long been associated with gene repression, there is limited evidence to support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21a8aa67cc2675caf306d153af92046e
https://doi.org/10.1101/2023.01.14.524033
https://doi.org/10.1101/2023.01.14.524033
Autor:
M. Azim Surani, Susana M. Chuva de Sousa Lopes, Kaiqin Lao, Alexander Tarakhovsky, Eric A. Miska, Masahiro Kaneda, Petra Hajkova, Katsuhiko Hayashi, Fuchou Tang, Partha Pratim Das, Dónal O'Carroll
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1738 (2008)
PLoS ONE
PLoS ONE
BACKGROUND: MicroRNAs (miRNAs) are critical regulators of transcriptional and post-transcriptional gene silencing, which are involved in multiple developmental processes in many organisms. Apart from miRNAs, mouse germ cells express another type of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4008546728b2cc3cf0ab101b231eed0b
Autor:
Marc-Werner Dobenecker, Annette Becker, Eugene Rudensky, Jonas Marcello, Alexander Tarakhovsky, Benjamin A. Garcia, Vyacheslav Yurchenko, Rabinder Kumar Prinjha, Thomas Carrol, Natarajan V. Bhanu
Publikováno v:
FEBS Lett
Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B cell subsets - B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900d6987c564a4c02be0903c6e819c0e
https://pubmed.ncbi.nlm.nih.gov/32862441
https://pubmed.ncbi.nlm.nih.gov/32862441
Autor:
Carolina Adura, Alan Gerber, Alexander Tarakhovsky, Dinshaw J. Patel, Diego Mourao, Benjamin A Garcia, Henrik Molina, Matthew R. Paul, Inmaculada Rioja, Charles M. Rice, Natarajan V. Bhanu, Leticia A.M. Carneiro, Robert G. Roeder, Brian D. Dill, Thomas L. Carroll, Gerard Joberty, Rab K. Prinjha, Shoudeng Chen, Leonia Bozzacco, Uwe Schaefer, Margaret R. MacDonald
Publikováno v:
bioRxiv, 2020. Cold Spring Harbor Laboratory Press
Mourao, D, Chen, S, Schaefer, U, Bozzacco, L, Carneiro, L A, Gerber, A, Adura, C, Dill, B D, Molina, H, Carroll, T, Paul, M, Bhanu, N V, Garcia, B A, Joberty, G, Rioja, I, Prinjha, R K, Roeder, R G, Rice, C M, MacDonald, M R, Patel, D J & Tarakhovsky, A 2020, ' A histone-like motif in yellow fever virus contributes to viral replication ', bioRxiv, vol. 2020 . https://doi.org/10.1101/2020.05.05.078782
Mourao, D, Chen, S, Schaefer, U, Bozzacco, L, Carneiro, L A, Gerber, A, Adura, C, Dill, B D, Molina, H, Carroll, T, Paul, M, Bhanu, N V, Garcia, B A, Joberty, G, Rioja, I, Prinjha, R K, Roeder, R G, Rice, C M, MacDonald, M R, Patel, D J & Tarakhovsky, A 2020, ' A histone-like motif in yellow fever virus contributes to viral replication ', bioRxiv, vol. 2020 . https://doi.org/10.1101/2020.05.05.078782
The mimicry of host proteins by viruses contributes to their ability to suppress antiviral immunity and hijack host biosynthetic machinery1. Host adaptation to evade this exploitation depends on host protein functional redundancy2. Non-redundant, ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cf35bd9001f77ec669a28d3ab24aa3
https://research.vu.nl/en/publications/f6715f1a-4a11-4342-a462-0d6a0020ccd0
https://research.vu.nl/en/publications/f6715f1a-4a11-4342-a462-0d6a0020ccd0
Autor:
Bahareh Haddad, Alex Rialdi, Ernesto Guccione, Jessica Sook Yuin Ho, Kimaada Allette, Natasha Moshkina, Minji Byun, Jian Jin, Adolfo García-Sastre, Sweta Ravisankar, Nevan J. Krogan, Randy A. Albrecht, Dalila Pinto, Rab K. Prinjha, Terrence M. Tumpey, Vittorio Sebastiano, Nacho Mena, Judd F. Hultquist, Alexander Tarakhovsky, Massimo Squatrito, Vyacheslav Yurchenko, Nan Zhao, Diana Low, Juan Ayllon, Ivan Marazzi, Yixuan Ma, Melissa Smith, Romain Fenouil, David Jimenez-Morales, Harm van Bakel, Benjamin Greenbaum, Maria Teresa Sánchez-Aparicio, Robert Sebra
Publikováno v:
Nature Structural & Molecular Biology. 25:885-893
Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, and genetic tools, we reveal that influenza A virus (IAV) infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052ce431bd6d3be6be6fe4aecf25355c
https://doi.org/10.1038/s41594-018-0124-7
https://doi.org/10.1038/s41594-018-0124-7
Autor:
Marc-Werner Dobenecker, Rab K. Prinjha, Anna K. Bassil, Alexander Tarakhovsky, Michael T. McCabe, Richard Gregory, Inmaculada Rioja, Joon Seok Park, Steven D. Knight, Jonas Marcello
Publikováno v:
The Journal of Experimental Medicine
PRC2 is a known chromatin regulator. Here the authors show novel cytosolic components of PRC2 and that PRC2 inactivation results in attenuation of MAPK/Erk signaling and impaired T cell activation. Systemic PRC2 inhibition in vivo cures the autoimmun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097d923dc52893e51f5de6bd67c83492
https://doi.org/10.1084/jem.20170084
https://doi.org/10.1084/jem.20170084