Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Alexander T. Wenzel"'
Autor:
Alexander T. Wenzel, Devora Champa, Hrishi Venkatesh, Si Sun, Cheng-Yu Tsai, Jill P. Mesirov, Jack D. Bui, Stephen B. Howell, Olivier Harismendy
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-9 (2022)
Abstract The molecular underpinnings of acquired resistance to carboplatin are poorly understood and often inconsistent between in vitro modeling studies. After sequential treatment cycles, multiple isogenic clones reached similar levels of resistanc
Externí odkaz:
https://doaj.org/article/ac7186de5d634c64a6af4e80fed859ec
Autor:
Anne Richelle, Benjamin P. Kellman, Alexander T. Wenzel, Austin W.T. Chiang, Tyler Reagan, Jahir M. Gutierrez, Chintan Joshi, Shangzhong Li, Joanne K. Liu, Helen Masson, Jooyong Lee, Zerong Li, Laurent Heirendt, Christophe Trefois, Edwin F. Juarez, Tyler Bath, David Borland, Jill P. Mesirov, Kimberly Robasky, Nathan E. Lewis
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 3, Pp 100040- (2021)
Summary: Omics experiments are ubiquitous in biological studies, leading to a deluge of data. However, it is still challenging to connect changes in these data to changes in cell functions because of complex interdependencies between genes, proteins,
Externí odkaz:
https://doaj.org/article/c23044d9a67944aeafbcd03821f78050
Autor:
Clarence K. Mah, Alexander T. Wenzel, Edwin F. Juarez, Thorin Tabor, Michael M. Reich, Jill P. Mesirov
Publikováno v:
F1000Research, Vol 7 (2019)
Single-cell RNA sequencing (scRNA-seq) has emerged as a popular method to profile gene expression at the resolution of individual cells. While there have been methods and software specifically developed to analyze scRNA-seq data, they are most access
Externí odkaz:
https://doaj.org/article/84c5a4cadaec4b25875d585a8538e4fb
Autor:
Jason K. Sicklick, Pablo Tamayo, Robert J. Wechsler-Reya, Jill P. Mesirov, Huwate Yeerna, Alexander T. Wenzel, Mayra Yebra, Chih-Min Tang, Stephanie Ting, Hyunho Yoon, Sudeep Banerjee
Supplementary FIG. 1 IM increases expression of stem markers and decreases KIT in human GIST. Supplementary FIG. 2 Cell cycle analysis of KITHigh and KITLow cells. Supplementary FIG. 3 TKI treatment enriches for KITlow GIST cells additional data. Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afbdfc58ded654307036bfb5dc5daad
https://doi.org/10.1158/1535-7163.22521366.v1
https://doi.org/10.1158/1535-7163.22521366.v1
Autor:
Eliah Aronoff-Spencer, Camille Nebeker, Alexander T. Wenzel, Kevin Nguyen, Rachel Kunowski, Mingjia Zhu, Gary Adamos, Ravi Goyal, Sepideh Mazrouee, Aaron Reyes, Nicole May, Holly Howard, Christopher A. Longhurst, Mohsen Malekinejad
Publikováno v:
Public health reports (Washington, D.C. : 1974), vol 137, iss 2_suppl
Objectives: Toward common methods for system monitoring and evaluation, we proposed a key performance indicator framework and discussed lessons learned while implementing a statewide exposure notification (EN) system in California during the COVID-19
Autor:
Sudeep Banerjee, Robert J. Wechsler-Reya, Jill P. Mesirov, Alexander T. Wenzel, Hyunho Yoon, Huwate Yeerna, Chih-Min Tang, Mayra Yebra, Pablo Tamayo, Stephanie Ting, Jason K. Sicklick
Publikováno v:
Molecular Cancer Therapeutics. 20:2035-2048
Gastrointestinal stromal tumor (GIST) is commonly driven by oncogenic KIT mutations that are effectively targeted by imatinib (IM), a tyrosine kinase inhibitor (TKI). However, IM does not cure GIST, and adjuvant therapy only delays recurrence in high
Publikováno v:
Cancer Research. 83:4281-4281
The use of gene expression data has been crucial to the functional characterization of changes in molecular pathway activity and for identifying targets for novel treatments. However, the interpretation of this data is complicated by its high dimensi
Autor:
Anthony S. Castanza, Jill M. Recla, David Eby, Alexander T. Wenzel, Helga Thorvaldsdottir, Carol J. Bult, Jill P. Mesirov
Publikováno v:
Cancer Research. 83:6568-6568
In 2005, we introduced the Gene Set Enrichment Analysis (GSEA) method to enable the identification and estimation of significance of activated biological pathways and processes in molecular data. Serving a community of over 300,000 registered users,
Autor:
Farah Jaber-Hijazi, Karthic Swaminathan, Kathryn Gilroy, Alexander T. Wenzel, Anthony Lagnado, Kristina Kirschner, Neil Robertson, Claire Reid, Neil Fullarton, Jeff Pawlikowski, Karen Blyth, Jill P. Mesirov, Taranjit Singh Rai, João F. Passos, Laura M. Machesky, Peter D. Adams
Histone chaperone HIRA is thought to play a role in both early development and aging, but little is known about connections between the two processes. Here, we explore this relationship using a lineage-specific knockout mouse model, TyrCre::Hirafl/fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a378d6a6790a57be336141e1e20372e
https://doi.org/10.1101/2022.04.22.489166
https://doi.org/10.1101/2022.04.22.489166
Autor:
Alexander T. Wenzel, Devora Champa, Hrishi Venkatesh, Si Sun, Cheng-Yu Tsai, Jill P. Mesirov, Jack D. Bui, Stephen B. Howell, Olivier Harismendy
Publikováno v:
NPJ systems biology and applications, vol 8, iss 1
The molecular underpinnings of acquired resistance to carboplatin are poorly understood and often inconsistent between in vitro modeling studies. After sequential treatment cycles, multiple isogenic clones reached similar levels of resistance, but si