Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alexander T El Gammal"'
Autor:
Christin Krause, Martina Grohs, Alexander T El Gammal, Stefan Wolter, Hendrik Lehnert, Oliver Mann, Jens Mittag, Henriette Kirchner
Publikováno v:
Endocrine Connections, Vol 7, Iss 12, Pp 1448-1456 (2018)
Hepatic thyroid hormone signaling has an important role in the development and progression of nonalcoholic steatohepatitis (NASH). While the systemic levels of thyroid hormone might remain stable, there is evidence that the intracellular signaling ma
Externí odkaz:
https://doaj.org/article/6a187e65294446b197f92f7400602be1
Autor:
Cathleen Geißler, Christin Krause, Joachim Spranger, Henriette Kirchner, Alexander T. El Gammal, Heidi Tackenberg, Stefan Wolter, Hendrik Lehnert, Oliver Mann
Publikováno v:
Diabetologia
Aims/hypothesis IRS2 is an important molecular switch that mediates insulin signalling in the liver. IRS2 dysregulation is responsible for the phenomenon of selective insulin resistance that is observed in type 2 diabetes. We hypothesise that epigene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cbe61f2d9d4954a911fc7670009b00
https://doi.org/10.1007/s00125-020-05212-6
https://doi.org/10.1007/s00125-020-05212-6
Autor:
Chris Meier, Nadine Wenzel, Jakob R. Izbicki, Daniel Perez, Faik G. Uzunoglu, Dichao Yao, Svetlana Kapis, Johanna Lüddeke, Sarah L. Spriestersbach, Katharina Grupp, Julia K. Graß, Dirk Landschulze, Annika Wolski, Udo Schumacher, Anika Buchholz, Guido Sauter, Leonie Konczalla, Cenap Güngör, Pablo Steinberg, Bianca T. Hofmann, Gerrit Wolters-Eisfeld, Alexander T. El Gammal, Christian Betzel, Clarissa Klemp, Klaus Püschel, Maximillian Bockhorn, Theresa Nuguid
Publikováno v:
International Journal of Cancer. 146:1618-1630
MALT1 is a key mediator of NF-κB signaling and a main driver of B-cell lymphomas. Remarkably, MALT1 is expressed in the majority of pancreatic ductal adenocarcinomas (PDACs) as well, but absent from normal exocrine pancreatic tissue. Following, MALT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbd5063ba7782ed49c7d269cb243eaf
https://doi.org/10.1002/ijc.32567
https://doi.org/10.1002/ijc.32567
Autor:
Hendrik Lehnert, Olena Ohlei, Meike Kasten, Henriette Kirchner, Stefan Wolter, Oliver Mann, Christine Klein, Fabian Kilpert, Georg Brabant, Helen Sievert, Martina Grohs, Cathleen Geißler, Alexander T. El Gammal, Ulrike M. Krämer, Christin Krause
Publikováno v:
Epigenomics. 11:885-897
Aim: Validation of epigenome-wide association studies is sparse. Therefore, we evaluated the methylation markers cg06500161 ( ABCG1) and cg11024682 ( SREBF1) as classifiers for diabetes stratification. Patients & methods: DNA methylation was measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d20aee6870fe2d76521c2f57a1a74b
https://doi.org/10.2217/epi-2018-0159
https://doi.org/10.2217/epi-2018-0159
Autor:
Nathaniel Melling, Jakob R. Izbicki, Alexander T. El Gammal, Kai Bachmann, Oliver Mann, Florian Gebauer, Maximillian Bockhorn, Matthias Reeh, Katharina Grupp, Daniel Perez
Publikováno v:
Experimental and Molecular Pathology. 107:51-56
Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234920961682447cfad3d9557575a68d
https://doi.org/10.1016/j.yexmp.2019.01.013
https://doi.org/10.1016/j.yexmp.2019.01.013
Autor:
Jakob R. Izbicki, Nathaniel Melling, Kai Bachmann, Matthias Reeh, Marco Blessmann, Oliver Mann, Katharina Grupp, Alexander T. El Gammal, Christoph Moebius, Bianca T. Hofmann
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 145:873-879
Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda1cf072ac0e63fc3f49c60309cf92d
https://doi.org/10.1007/s00432-019-02850-1
https://doi.org/10.1007/s00432-019-02850-1
Autor:
Rebecca Oelkrug, Henriette Kirchner, Alexander T. El Gammal, Oliver Mann, Julia Resch, Jens Mittag, Christin Krause, Sogol Gachkar, Stefan Wolter, Beate Herrmann, Henrik Oster
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108351-(2020)
Summary: Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection. Here, we show in mice that even minor changes in maternal therm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cd772c99ac732b312c084a85b58441
http://www.sciencedirect.com/science/article/pii/S2211124720313401
http://www.sciencedirect.com/science/article/pii/S2211124720313401
Autor:
Martina Grohs, Helen Sievert, Stefan Wolter, Cathleen Geißler, Hendrik Lehnert, Christin Krause, Oliver Mann, Henriette Kirchner, Alexander T El-Gammal
Publikováno v:
Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 129(9)
Objective The risk to develop type 2 diabetes increases with the amount of visceral adiposity presumably due to increased lipolysis and subsequent lipid accumulation in visceral organs. However, data describing the molecular regulation of these pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517ea72b6fcb50a10ab212224b3fb54a
https://pubmed.ncbi.nlm.nih.gov/32434239
https://pubmed.ncbi.nlm.nih.gov/32434239
Autor:
Martina Grohs, Christin Krause, Oliver Mann, Henriette Kirchner, Stefan Wolter, Hendrik Lehnert, Alexander T. El Gammal, Jens Mittag
Publikováno v:
Endocrine Connections
Endocrine Connections, Vol 7, Iss 12, Pp 1448-1456 (2018)
Endocrine Connections, Vol 7, Iss 12, Pp 1448-1456 (2018)
Hepatic thyroid hormone signaling has an important role in the development and progression of nonalcoholic steatohepatitis (NASH). While the systemic levels of thyroid hormone might remain stable, there is evidence that the intracellular signaling ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edc8f895dca2db6ad9ccd6e56af761b
http://europepmc.org/articles/PMC6300861
http://europepmc.org/articles/PMC6300861
Autor:
Faik G. Uzunoglu, Maximillian Bockhorn, Matthias Reeh, Tarik Ghabdan, Asad Kutup, Jakob R. Izbicki, Gerrit Wolters-Eisfeld, Michael F. Nentwich, Asmus Heumann, Eugen Bellon, Alexander T. El Gammal, Katharina Grupp, Kai Bachmann, Dean Bogoevski, Bianca T. Hofmann, Nathaniel Melling, Rainer Grotelüschen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
The function of Forkhead box O 1 (FOXO1) and pSerine256-FOXO1 immunostaining in esophageal cancer is unclear. To clarify the prognostic role of nuclear FOXO1 and cytoplasmic pSerine256-FOXO1 immunostaining, a tissue microarray containing more than 60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e452e2e2a63121a1a6cecc33970194
http://link.springer.com/article/10.1038/s41598-018-35459-4
http://link.springer.com/article/10.1038/s41598-018-35459-4