Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Alexander T, Williams"'
Autor:
Cynthia R. Muller, Alexander T. Williams, Allyn M. Eaker, Cynthia Walser, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116789- (2024)
The widespread adoption of high-calorie, high-fat, high-sucrose diets (HFHSD) has become a global health concern, particularly due to their association with cardiovascular diseases and metabolic disorders. These comorbidities increase susceptibility
Externí odkaz:
https://doaj.org/article/b20cb5ee5fce46bfbb87368a929784a2
Autor:
Alexander T. Williams, Jing Chen, Kayesha Coley, Chiara Batini, Abril Izquierdo, Richard Packer, Erik Abner, Stavroula Kanoni, David J. Shepherd, Robert C. Free, Edward J. Hollox, Nigel J. Brunskill, Ioanna Ntalla, Nicola Reeve, Christopher E. Brightling, Laura Venn, Emma Adams, Catherine Bee, Susan E. Wallace, Manish Pareek, Anna L. Hansell, Tõnu Esko, Estonian Biobank Research Team, Daniel Stow, Benjamin M. Jacobs, David A. van Heel, Genes & Health Research Team, William Hennah, Balasubramanya S. Rao, Frank Dudbridge, Louise V. Wain, Nick Shrine, Martin D. Tobin, Catherine John
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide association study of
Externí odkaz:
https://doaj.org/article/e621fa13197b48d594bb390c78b9b2c1
Autor:
Sina A. Gharib, Louise V. Wain, Tõnu Esko, Gail P. Jarvik, Scott Hebbring, Eric B. Larson, Sarah H. Landis, Ruth J.F. Loos, Jiangyuan Liu, Caroline Hayward, Arden Moscati, Yuan Luo, Bahram Namjou, Hana Mullerova, Marjo-Riitta Järvelin, Jennifer K. Quint, Eeva Sliz, Marylyn D. Ritchie, Laurent Thomas, Ian B. Stanaway, Kristian Hveem, David Michalovich, Ian P. Hall, James F. Wilson, Jing Chen, Alexander T. Williams, Martin D. Tobin, Joanna C. Betts, Hardeep Naghra-van Gijzel, Richard Packer, Edith M. Hessel, Astrid J. Yeo, Nicola F. Reeve, Bjørn Olav Åsvold, Erik Abner, Archie Campbell, Traci M. Bartz, Juha Auvinen, Catherine John, Ben Brumpton, Yuki Bradford, Su Chu, David J. Porteous, Nick Shrine, Michael H. Cho, QiPing Feng, David R. Crosslin
Publikováno v:
Wellcome Open Research, Vol 6 (2023)
Background: Globally, respiratory infections contribute to significant morbidity and mortality. However, genetic determinants of respiratory infections are understudied and remain poorly understood. Methods: We conducted a genome-wide association stu
Externí odkaz:
https://doaj.org/article/c17a2bf7fdb5446eaddb34047fe072d7
Autor:
Cynthia R. Muller, Alexander T. Williams, Cynthia Walser, Allyn M. Eaker, Jose Luis Sandoval, Clayton T. Cuddington, Savannah R. Wolfe, Andre F. Palmer, Pedro Cabrales
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract For the past thirty years, hemoglobin-based oxygen carriers (HBOCs) have been under development as a red blood cell substitute. Side-effects such as vasoconstriction, oxidative injury, and cardiac toxicity have prevented clinical approval of
Externí odkaz:
https://doaj.org/article/7392dcbf710e404e92a253d0ccde2b43
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Fluid resuscitation following severe inflammation-induced hypoperfusion is critical for the restoration of hemodynamics and the prevention of multiorgan dysfunction syndrome during septic shock. Fluid resuscitation with commercially availabl
Externí odkaz:
https://doaj.org/article/c975693a2e82403babdaba58ccc0bc55
Autor:
Cynthia R. Muller, Vasiliki Courelli, Alfredo Lucas, Alexander T. Williams, Joyce B. Li, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Moses, Andre F. Palmer, Erik B. Kistler, Pedro Cabrales
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock (HS) after TBI is particularly challenging because the two therapeutic treatment strategies for TBI and HS often conflict. Ischemia/reperfusi
Externí odkaz:
https://doaj.org/article/498e933377124b19800d64b418baa677
Publikováno v:
IEEE Journal of Translational Engineering in Health and Medicine, Vol 7, Pp 1-9 (2019)
This paper implements logistic regression models (LRMs) and feature selection for creating a predictive model for recovery form hemorrhagic shock (HS) with resuscitation using blood in the multiple experimental rat animal protocols. A total of 61 ani
Externí odkaz:
https://doaj.org/article/f38d7abdac1c4c94a557da4e968312ca
Autor:
Vinay P. Jani, Vivek P. Jani, Carlos J. Munoz, Krianthan Govender, Alexander T. Williams, Pedro Cabrales
Publikováno v:
Physiological Reports, Vol 9, Iss 5, Pp n/a-n/a (2021)
Abstract Microvascular fluid exchange is primarily dependent on Starling forces and both the active and passive myogenic response of arterioles and post‐capillary venules. Arterioles are classically considered resistance vessels, while venules are
Externí odkaz:
https://doaj.org/article/fb7699bc83764c809b0ffdcd74b8b173
Autor:
Vivek P. Jani, Alfredo Lucas, Vinay P. Jani, Carlos Munoz, Alexander T. Williams, Daniel Ortiz, Ozlem Yalcin, Pedro Cabrales
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
The mechanical properties and deformability of Red Blood Cells (RBCs) are important determinants of blood rheology and microvascular hemodynamics. The objective of this study is to quantify the mechanical properties and wall shear stress experienced
Externí odkaz:
https://doaj.org/article/f1599dd5a8354c868c6178ab3e5ad190
Autor:
Alfredo Lucas, Eilleen S. Y. Ao-ieong, Alexander T. Williams, Vivek P. Jani, Cynthia R. Muller, Ozlem Yalcin, Pedro Cabrales
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Acclimatization to hypoxia or high altitude involves physiological adaptation processes, to influence oxygen (O2) transport and utilization. Several natural products, including aromatic aldehydes and isothiocyanates stabilize the R-state of hemoglobi
Externí odkaz:
https://doaj.org/article/da869c996f46493b82da431a50c2ea18