Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander T, Bakker"'
Autor:
Sebastiaan T. A. Koenders, Lukas S. Wijaya, Martje N. Erkelens, Alexander T. Bakker, Vera E. van der Noord, Eva J. van Rooden, Lindsey Burggraaff, Pasquale C. Putter, Else Botter, Kim Wals, Hans van den Elst, Hans den Dulk, Bogdan I. Florea, Bob van de Water, Gerard J. P. van Westen, Reina E. Mebius, Herman S. Overkleeft, Sylvia E. Le Dévédec, Mario van der Stelt
Publikováno v:
ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)
Externí odkaz:
https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017
Autor:
Alexander T. Bakker, Ioli Kotsogianni, Liza Mirenda, Verena M. Straub, Mariana Avalos, Richard J. B. H. N. van den Berg, Bogdan I. Florea, Gilles P. van Wezel, Antonius P. A. Janssen, Nathaniel I. Martin, Mario van der Stelt
Publikováno v:
Journal of the American Chemical Society, 145(2), 1136-1143. American Chemical Society (ACS)
Phenotypic screening is a powerful approach to identify novel antibiotics, but elucidation of the targets responsible for the antimicrobial activity is often challenging in the case of compounds with a polypharmacological mode of action. Here, we sho
Autor:
Annelot C. M. van Esbroeck, Vasudev Kantae, Xinyu Di, Tom van der Wel, Hans den Dulk, Anna F. Stevens, Simar Singh, Alexander T. Bakker, Bogdan I. Florea, Nephi Stella, Herman S. Overkleeft, Thomas Hankemeier, Mario van der Stelt
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
The endocannabinoid 2-arachidonoylglycerol (2-AG) is involved in neuronal differentiation. This study aimed to identify the biosynthetic enzymes responsible for 2-AG production during retinoic acid (RA)-induced neurite outgrowth of Neuro-2a cells. Fi
Externí odkaz:
https://doaj.org/article/6cd12365d20340a299dc09570d0ea0e6
Autor:
Karol Al Ayed, Ross D. Ballantine, Michael Hoekstra, Samantha J. Bann, Charlotte M. J. Wesseling, Alexander T. Bakker, Zheng Zhong, Yong-Xin Li, Nora C. Brüchle, Mario van der Stelt, Stephen A. Cochrane, Nathaniel I. Martin
Publikováno v:
Chemical Science, 13(12), 3563-3570. Royal Society of Chemistry (RSC)
Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d745f9e19bc1cc2b080c620d433bcaa3
http://hdl.handle.net/1887/3304472
http://hdl.handle.net/1887/3304472
Autor:
Karol, Al Ayed, Ross D, Ballantine, Michael, Hoekstra, Samantha J, Bann, Charlotte M J, Wesseling, Alexander T, Bakker, Zheng, Zhong, Yong-Xin, Li, Nora C, Brüchle, Mario, van der Stelt, Stephen A, Cochrane, Nathaniel I, Martin
Publikováno v:
Chemical science. 13(12)
Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select
Autor:
Hans den Dulk, Reina E Mebius, Eva J. van Rooden, Hans van den Elst, Pasquale C Putter, Bob van de Water, Else Botter, Gerard J. P. van Westen, Alexander T Bakker, Vera E. van der Noord, Bogdan I. Florea, Mario van der Stelt, Kim Wals, Sylvia E. Le Dévédec, Sebastiaan T A Koenders, Herman S. Overkleeft, Lukas S Wijaya, Martje N. Erkelens, Lindsey Burggraaff
Publikováno v:
ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)
ACS Central Science, 5(12), 1965-1974
ACS Central Science, 5(12), 1965-1974. American Chemical Society
ACS Central Science
Koenders, S T A, Wijaya, L S, Erkelens, M N, Bakker, A T, van der Noord, V E, van Rooden, E J, Burggraaff, L, Putter, P C, Botter, E, Wals, K, van den Elst, H, den Dulk, H, Florea, B I, van de Water, B, van Westen, G J P, Mebius, R E, Overkleeft, H S, Le Dévédec, S E & van der Stelt, M 2019, ' Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells ', ACS Central Science, vol. 5, no. 12, pp. 1965-1974 . https://doi.org/10.1021/acscentsci.9b01022
ACS Central Science, 5(12), 1965-1974
ACS Central Science, 5(12), 1965-1974. American Chemical Society
ACS Central Science
Koenders, S T A, Wijaya, L S, Erkelens, M N, Bakker, A T, van der Noord, V E, van Rooden, E J, Burggraaff, L, Putter, P C, Botter, E, Wals, K, van den Elst, H, den Dulk, H, Florea, B I, van de Water, B, van Westen, G J P, Mebius, R E, Overkleeft, H S, Le Dévédec, S E & van der Stelt, M 2019, ' Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells ', ACS Central Science, vol. 5, no. 12, pp. 1965-1974 . https://doi.org/10.1021/acscentsci.9b01022
Retinaldehyde dehydrogenases belong to a superfamily of enzymes that regulate cell differentiation and are responsible for detoxification of anticancer drugs. Chemical tools and methods are of great utility to visualize and quantify aldehyde dehydrog
Autor:
Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa
Publikováno v:
Nature Chemical Biology, 16(6), 667-675
Nat Chem Biol
Nat Chem Biol
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858eb516053df2c6e71eaf7ba6acceef
https://www.nature.com/articles/s41589-020-0528-7
https://www.nature.com/articles/s41589-020-0528-7
Autor:
Hans den Dulk, Laura Mulder, Lindsey Burggraaff, Thomas Hankemeier, Juan Zhou, Marc P. Baggelaar, Andrea Martella, Bogdan I. Florea, Alexander T Bakker, Mario van der Stelt, Karol Al-Ayed, Chun T. Li, Gerard J. P. van Westen, Herman S. Overkleeft, Vasudev Kantae, Elliot D. Mock, Xinyu Di, Sebastian H. Grimm
Publikováno v:
ACS Chemical Biology, 14(2), 164-169
ACS Chemical Biology
ACS Chemical Biology
Phospholipase A2, group XVI (PLA2G16) is a thiol hydrolase from the HRASLS family that regulates lipolysis in adipose tissue and has been identified as a host factor enabling the cellular entry of picornaviruses. Chemical tools are essential to visua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca19c73d265df10e65e3bb195c5746cb
http://hdl.handle.net/1887/69904
http://hdl.handle.net/1887/69904
Autor:
Giuseppe Campiani, Antonius P A Janssen, Stefania Butini, Daan van der Vliet, Sebastian H. Grimm, Mario van der Stelt, Ming Jiang, Alexander T Bakker
Publikováno v:
ACS Chemical Biology, 13(9), 2406-2413
ACS Chemical Biology
ACS Chemical Biology
Endocannabinoids, an important class of signaling lipids involved in health and disease, are predominantly synthesized and metabolized by enzymes of the serine hydrolase superfamily. Activity-based protein profiling (ABPP) using fluorescent probes, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1b358bcd699473e5e3e01da7422e90
http://hdl.handle.net/11365/1058758
http://hdl.handle.net/11365/1058758