Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alexander Syme"'
Autor:
Philip W. Brownjohn, Azedine Zoufir, Daniel J. O’Donovan, Saatviga Sudhahar, Alexander Syme, Rosemary Huckvale, John R. Porter, Hester Bange, Jane Brennan, Neil T. Thompson
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Autosomal dominant polycystic kidney disease (ADPKD) is a rare genetic disorder characterised by numerous renal cysts, the progressive expansion of which can impact kidney function and lead eventually to renal failure. Tolvaptan is the only disease-m
Externí odkaz:
https://doaj.org/article/f0f14632f7bf4fa7be3e8e7254e4258c
Autor:
Sarah Rose, Robert C. Hider, Bruce Campbell, Kayhan A. Tayarani-Binazir, Christopher Hobbs, Alexander Syme, Mark Jairaj, Tao Zhou, Peter Jenner
Publikováno v:
European Journal of Medicinal Chemistry. 45:4035-4042
A range of amide derivatives of L-dopa were synthesized and investigated for their pharmacological activity and their ability to be converted to L-dopa using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat, as an experimental model of Parkin
Autor:
Mark Jairaj, Tao Zhou, Sarah Rose, Robert C. Hider, Christopher Hobbs, Alexander Syme, Peter Jenner, Bruce Campbell, Kayhan A. Tayarani-Binazir
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(19)
A series of dipeptide derivatives of L-dopa were synthesized and investigated for their pharmacological activity using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat as an experimental model of Parkinson's disease. Among them, (S)-isopropyl
Autor:
Jonathan Papworth, Alexander Syme, Anthony Groom, Adam Lucas, Lee Dawson, Toshal Patel, Janette Robertson, Jane Gartlon
Publikováno v:
Alzheimer's & Dementia. 8
dementia. Conclusions: Our findings indicate that following cardiac surgery the number of individuals identified as at risk of dementia is much higher than expected in the general population (0.3-0.8% per year) as more than 50% of individuals were af