Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alexander Sternjak"'
Autor:
Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Carolien P. Schröder, Anton G.T. Terwisscha van Scheltinga, H. Kam Cheung, Alexander Sternjak, Matthias Friedrich, Sabine Stienen, Frank J. Warnders, Stijn J.H. Waaijer
Purpose: AMG 211, a bispecific T-cell engager (BiTE) antibody construct, targets carcinoembryonic antigen (CEA) and the CD3 epsilon subunit of the human T-cell receptor. AMG 211 was labeled with zirconium-89 (89Zr) or fluorescent dye to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef2a933f924d3d901ce5cf7df51972b
https://doi.org/10.1158/1078-0432.c.6529296.v1
https://doi.org/10.1158/1078-0432.c.6529296.v1
Autor:
Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Carolien P. Schröder, Anton G.T. Terwisscha van Scheltinga, H. Kam Cheung, Alexander Sternjak, Matthias Friedrich, Sabine Stienen, Frank J. Warnders, Stijn J.H. Waaijer
Supplementary Figures S1-S4 and Supplementary Table S1 including Supplementary Figure legend and Supplementary Table caption Figure S1. Flow chart of the drug substance (N-sucDf-AMG211) manufacturing process and drug product (89Zr-AMG211) formulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073c21bb4b1fb1b2e518864fa651aaeb
https://doi.org/10.1158/1078-0432.22476105
https://doi.org/10.1158/1078-0432.22476105
Autor:
Mercedesz Balazs, Alexander Sternjak, Edwin Lamas, Ana Goyos, Petra Deegen, Benno Rattel, Joachim Wahl, Mozhgan Farshbaf, Angela Coxon, Xiaoshan Min, Tara Arvedson, Matthias Klinger, Oliver Thomas, Chi-Ming Li, Pamela Bogner, Matthias Friedrich, Rebecca Goldstein, Athena Sudom
Publikováno v:
Blood Adv
Multiple myeloma (MM) is a hematologic malignancy that is characterized by the accumulation of abnormal plasma cells (PCs) in the bone marrow (BM). Patient outcome may be improved with BiTE (bispecific T-cell engager) molecules, which redirect T cell
Autor:
Ines Ullrich, Oliver Thomas, Markus Muenz, Benno Rattel, Mercedesz Balazs, Julie M. Bailis, Joachim Wahl, Alexander Sternjak, Fei Lee, Grit Lorenczewski, Matthias Friedrich
Publikováno v:
Molecular cancer therapeutics. 20(5)
AMG 596 is a bispecific T-cell engager (BiTE) immuno-oncology therapy in clinical development for treatment of glioblastoma multiforme (GBM), the most common primary brain tumor in adults with limited therapeutic options. AMG 596 is composed of two s
Autor:
Benno Rattel, Anja Henn, Tobias Raum, Shyun Li, Julie M. Bailis, Michael C. Boyle, Virginie Naegele, Alexander Sternjak, Angela Coxon, Joachim Wahl, Christoph Dahlhoff, Oliver Thomas, Petra Lutterbuese, Kathrin Locher, John M. Harrold
Publikováno v:
Cancer Research. 80:3364-3364
Advanced gastric cancer remains a disease of high unmet medical need. In the United States, most patients present with symptomatic, incurable disease and prognosis is poor, with a 5-year survival rate of less than 10%. BiTE® (bispecific T cell engag
Autor:
Elisabeth G.E. de Vries, H. Kam Cheung, Anton G.T. Terwisscha van Scheltinga, Frank J. Warnders, Marjolijn N. Lub-de Hooge, Carolien P. Schröder, Stijn J.H. Waaijer, Sabine Stienen, Alexander Sternjak, Matthias Friedrich
Publikováno v:
Clinical Cancer Research, 24(20), 4988-4996. AMER ASSOC CANCER RESEARCH
Purpose: AMG 211, a bispecific T-cell engager (BiTE) antibody construct, targets carcinoembryonic antigen (CEA) and the CD3 epsilon subunit of the human T-cell receptor. AMG 211 was labeled with zirconium-89 (89Zr) or fluorescent dye to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da049d28f4c2be21fb052068b88670c7
https://europepmc.org/articles/PMC6193542/
https://europepmc.org/articles/PMC6193542/
A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema
Autor:
Christoph Grüber, Michael Kurek, Renate Nickel, Christiane Chen, Ulrich Wahn, Florian Schulz, Jorge Esparza-Gordillo, Franz Rüschendorf, Regina Fölster-Holst, Monika Stoll, Ingo Marenholz, Alexander Sternjak, Young-Ae Lee, Ria Baumgrass, Norbert Hubner, Stefan Schreiber
Publikováno v:
Journal of Allergy and Clinical Immunology. 120:1097-1102
Background IL-31 is a novel cytokine that, when overexpressed in transgenic mice, induces severe itching dermatitis resembling human eczema. Objective We aimed to evaluate the importance of polymorphisms in the human IL-31 gene ( IL31 ) in the geneti
Autor:
Alexander Sternjak, Joachim Wahl, Matthias Friedrich, Ralf Lutterbuese, Julie M. Bailis, Peter Kufer, Dan A. Rock, Fei Lee, Angela Coxon, Sabine Stienen, Benno Rattel, Patrick Hoffmann, Tobias Raum, Oliver Thomas
Publikováno v:
Cancer Research. 77:3630-3630
Bispecific T cell engager (BiTE®) antibody constructs redirect T cells to induce lysis of tumor cells. The anti-CD19/CD3 BiTE® Blincyto® can deplete target cells in both the blood and tissue compartment in B cell malignancies, suggesting that the
Autor:
M. Voelkel, Matthias Friedrich, R. Kischel, Sabine Stienen, Benno Rattel, P. Kufer, Oliver Thomas, I. Herrmann, Alexander Sternjak, Joachim Wahl, M. Balazs, M. Muenz
Publikováno v:
European Journal of Cancer. 69:S96
Autor:
Wesley Chang, Jessica Orf, Ryan Case, Alexander Sternjak, Beth Hinkle, Brian Belmontes, Matthias Friedrich, Julie M. Bailis, Natalia Grinberg
Publikováno v:
Cancer Research. 76:4999-4999
Bispecific T-cell engaging (BiTE®) antibody constructs connect T cells to target-positive cells to induce cytotoxicity. Clinical proof of concept was achieved in B cell malignancies with the anti-CD19 BiTE® Blincyto®, and several BiTE® antibody c