Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Alexander Statnikov"'
Autor:
Glenn N Saxe, Alexander Statnikov, David Fenyo, Jiwen Ren, Zhiguo Li, Meera Prasad, Dennis Wall, Nora Bergman, Ernestine C Briggs, Constantin Aliferis
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151174 (2016)
Conventional research methodologies and data analytic approaches in psychiatric research are unable to reliably infer causal relations without experimental designs, or to make inferences about the functional properties of the complex systems in which
Externí odkaz:
https://doaj.org/article/5a7569833f874bf9ab7e1d9dd0045734
Autor:
Jun-Chieh J Tsay, Zhiguo Li, Ting-An Yie, Feng Wu, Leopoldo Segal, Alissa K Greenberg, Eric Leibert, Michael D Weiden, Harvey Pass, John Munger, Alexander Statnikov, Kam-Meng Tchou-Wong, William N Rom
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118132 (2015)
Field of cancerization in the airway epithelium has been increasingly examined to understand early pathogenesis of non-small cell lung cancer. However, the extent of field of cancerization throughout the lung airways is unclear. Here we sought to det
Externí odkaz:
https://doaj.org/article/4d8a56d7afdd40a48c32f4feb432a9f0
Publikováno v:
Cancer Informatics, Vol 2, Pp 133-162 (2006)
Sound data analysis is critical to the success of modern molecular medicine research that involves collection and interpretation of mass-throughput data. The novel nature and high-dimensionality in such datasets pose a series of nontrivial data analy
Externí odkaz:
https://doaj.org/article/9e67884e88754bcbbe1ad3a8001f1f04
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106479 (2014)
De-novo reverse-engineering of genome-scale regulatory networks is a fundamental problem of biological and translational research. One of the major obstacles in developing and evaluating approaches for de-novo gene network reconstruction is the absen
Externí odkaz:
https://doaj.org/article/238e6d087d424726902f8306681c7224
Autor:
Evgeny Shmelkov, Chavdar Krachmarov, Arsen V Grigoryan, Abraham Pinter, Alexander Statnikov, Timothy Cardozo
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89987 (2014)
The extreme diversity of HIV-1 strains presents a formidable challenge for HIV-1 vaccine design. Although antibodies (Abs) can neutralize HIV-1 and potentially protect against infection, antibodies that target the immunogenic viral surface protein gp
Externí odkaz:
https://doaj.org/article/66a77b485f8d461fb0bff52edfddbdcc
Autor:
Jonathan E Feig, Yuliya Vengrenyuk, Vladimir Reiser, Chaowei Wu, Alexander Statnikov, Constantin F Aliferis, Michael J Garabedian, Edward A Fisher, Oscar Puig
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39790 (2012)
We have developed a mouse model of atherosclerotic plaque regression in which an atherosclerotic aortic arch from a hyperlipidemic donor is transplanted into a normolipidemic recipient, resulting in rapid elimination of cholesterol and monocyte-deriv
Externí odkaz:
https://doaj.org/article/3029ae956da04c359ca18288dfac9d5a
Autor:
Nikita I Lytkin, Lauren McVoy, Jörn-Hendrik Weitkamp, Constantin F Aliferis, Alexander Statnikov
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20662 (2011)
The promise of modern personalized medicine is to use molecular and clinical information to better diagnose, manage, and treat disease, on an individual patient basis. These functions are predominantly enabled by molecular signatures, which are compu
Externí odkaz:
https://doaj.org/article/ca630c67d933414b88c1075dea2bc67a
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 5, p e1000790 (2010)
Molecular signatures are computational or mathematical models created to diagnose disease and other phenotypes and to predict clinical outcomes and response to treatment. It is widely recognized that molecular signatures constitute one of the most im
Externí odkaz:
https://doaj.org/article/47db678268fd44ac9967672c398e60a1
Autor:
Constantin F Aliferis, Alexander Statnikov, Ioannis Tsamardinos, Jonathan S Schildcrout, Bryan E Shepherd, Frank E Harrell
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4922 (2009)
Critical to the development of molecular signatures from microarray and other high-throughput data is testing the statistical significance of the produced signature in order to ensure its statistical reproducibility. While current best practices emph
Externí odkaz:
https://doaj.org/article/7b66c1c466654dabbe717271c8b0d916
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e958 (2007)
The development of new high-throughput genotyping technologies has allowed fast evaluation of single nucleotide polymorphisms (SNPs) on a genome-wide scale. Several recent genome-wide association studies employing these technologies suggest that pane
Externí odkaz:
https://doaj.org/article/5f24aef157b24bc0b14c73e132f291b7