Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alexander Spasov"'
Autor:
Alexander Spasov, Alexander Ozerov, Pavel Vassiliev, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Roman Litvinov, Alexander Borisov, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Georgy Uskov, Nadezhda Ovsyankina
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The Na+/H+ exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors
Externí odkaz:
https://doaj.org/article/95cb90e511f64954bcecb760473a9509
Autor:
Alexander Spasov, Irina Ovchinnikova, Olga Fedorova, Yulia Titova, Denis Babkov, Vadim Kosolapov, Alexander Borisov, Elena Sokolova, Vladlen Klochkov, Maria Skripka, Yulia Velikorodnaya, Alexey Smirnov, Gennady Rusinov, Valery Charushin
Publikováno v:
Molecules, Vol 28, Iss 2, p 741 (2023)
The problem of lung damage originating from excessive inflammation and cytokine release during various types of infections remains relevant and stimulates the search for highly effective and safe drugs. The biological activity of the latter may be as
Externí odkaz:
https://doaj.org/article/7e0ceab1ee0941dc94010563981558dd
Autor:
Evgeny Nikitin, Ekaterina Mironova, Dmitry Shpakovsky, Yulia Gracheva, Daniil Koshelev, Valentina Utochnikova, Konstantin Lyssenko, Yury Oprunenko, Dmitry Yakovlev, Roman Litvinov, Mariya Seryogina, Alexander Spasov, Elena Milaeva
Publikováno v:
Molecules, Vol 27, Iss 23, p 8359 (2022)
A novel polydentate chelating antioxidant ligand and series of organotin complexes on its base were synthesized and characterized by NMR 1H, 13C, 119Sn, IR spectroscopy, X-ray, and elemental analysis. Their antioxidant activity was evaluated in DPPH
Externí odkaz:
https://doaj.org/article/b5245a3933434c4096dc98894854e87e
Autor:
Elena Tretyakova, Irina Smirnova, Oxana Kazakova, Ha Thi Thu Nguyen, Alina Shevchenko, Elena Sokolova, Denis Babkov, Alexander Spasov
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13535 (2022)
The incidence of diabetes mellitus (DM), one of the most common chronic metabolic disorders, has increased dramatically over the past decade and has resulted in higher rates of morbidity and mortality worldwide. The enzyme, α-Glucosidase (α-GLy), i
Externí odkaz:
https://doaj.org/article/81478f4158084eb5ba0bae411ee158bb
Autor:
Alexander Spasov, Alexander Ozerov, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Alexander Borisov, Elena Sokolova, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Nadezhda Ovsyankina, Alexey Smirnov, Yulia Velikorodnaya
Publikováno v:
Life, Vol 12, Iss 10, p 1647 (2022)
Quinazolines are a rich source of bioactive compounds. Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a series of quinazoline-2,4(1H,3H)-diones and quinazoline-4(
Externí odkaz:
https://doaj.org/article/6046407ded4c4c97915720eb3c4bddcd
Autor:
Alexander Spasov, Vadim Kosolapov, Denis Babkov, Vladlen Klochkov, Elena Sokolova, Mikhail Miroshnikov, Alexander Borisov, Yulia Velikorodnaya, Alexey Smirnov, Konstantin Savateev, Victor Fedotov, Svetlana Kotovskaya, Vladimir Rusinov
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 537 (2022)
Acute lung injury remains a challenging clinical condition, necessitating the development of novel, safe and efficient treatments. The prevention of macrophage M1-polarization is a viable venue to tackle excessive inflammation. We performed a phenoty
Externí odkaz:
https://doaj.org/article/3bedc0deb3444faea52214804752d778
Autor:
Adrian Julian Marcus, Igor Iezhitsa, Renu Agarwal, Pavel Vassiliev, Alexander Spasov, Olga Zhukovskaya, Vera Anisimova, Nafeeza Mohd Ismail
Publikováno v:
Data in Brief, Vol 18, Iss , Pp 523-554 (2018)
This data is to document the intraocular pressure (IOP) lowering activity of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats. Effects of single drop application of imidazo[1,2-a]benzimidazole and pyr
Externí odkaz:
https://doaj.org/article/9c6634eadbd9459598ce6dc00cb96046
Autor:
Pavel Vassiliev, Igor Iezhitsa, Renu Agarwal, Adrian Julian Marcus, Alexander Spasov, Olga Zhukovskaya, Vera Anisimova
Publikováno v:
Data in Brief, Vol 18, Iss , Pp 340-347 (2018)
This article contains data that relate to the study carried out in the work of Marcus et al. (2018) [1]. Data represent an information about pharmacophore analysis of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives and result
Externí odkaz:
https://doaj.org/article/d372e0dd233645a19ba1d2b4f995a2db
Autor:
Alexey Sarapultsev, Pavel Vassiliev, Daniil Grinchii, Alexander Kiss, Mojmir Mach, Jana Osacka, Alexandra Balloova, Ruslan Paliokha, Andrey Kochetkov, Larisa Sidorova, Petr Sarapultsev, Oleg Chupakhin, Maxim Rantsev, Alexander Spasov, Eliyahu Dremencov
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13626 (2021)
Depression associated with poor general medical condition, such as post-stroke (PSD) or post-myocardial infarction (PMID) depression, is characterized by resistance to classical antidepressants. Special treatment strategies should thus be developed f
Externí odkaz:
https://doaj.org/article/8779cb30388f49e9bc7d2393fba8e940
