Výsledky vyhledávání - "Alexander Sirker"

Akademický článek

NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction–Induced Remodeling

Autor: Heloise Mongue-Din, PharmD, PhD, Ashish S. Patel, PhD, Yee H. Looi, PhD, David J. Grieve, PhD, Narayana Anilkumar, PhD, Alexander Sirker, PhD, Xuebin Dong, MD, PhD, Alison C. Brewer, PhD, Min Zhang, MD, PhD, Alberto Smith, PhD, Ajay M. Shah, MD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 688-698 (2017)

The reactive oxygen species–generating enzyme NADPH oxidase 4 (Nox4) is up-regulated in the heart after myocardial infarction (MI). Mice with cardiomyocyte-targeted Nox4 overexpression (TG) displayed increased macrophages in the heart at baseline,

Externí odkaz: https://doaj.org/article/d60b1b16e8464ba19d64e415d371d213

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Outcome of inter-hospital transfer versus direct admission for primary percutaneous coronary intervention: An observational study of 25,315 patients with ST-elevation myocardial infarction from the London Heart Attack Group

Autor: Ajay Jain, Sam Firoozi, Iqbal S. Malik, Miles Dalby, Krishnaraj S. Rathod, Daniel A. Jones, Alexander Sirker, Simon Redwood, Jo Nevett, Richard A. Boyle, Andrew Wragg, Sundeep Kalra, Anthony Mathur, Pitt Lim, Philip MacCarthy

Publikováno v: European heart journal. Acute cardiovascular care. 9(8)

Background and aims: In patients with ST-segment elevation myocardial infarction (STEMI), mortality is directly related to time to reperfusion with guidelines recommending patients be delivered directly to centres for primary percutaneous coronary in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc8c032862c357a986a1cc185230935
https://pubmed.ncbi.nlm.nih.gov/32193943

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Outcomes after chronic total occlusion percutaneous coronary interventions

Publikováno v: Coronary Artery Disease. 29:557-563

Chronic total occlusions (CTO) are commonly encountered in patients undergoing coronary angiography; however, percutaneous coronary intervention (PCI) is infrequently performed owing to technical difficulty, the perceived risk of complications and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cba6d8f74aa298ea3ce91bc8fc571d
https://doi.org/10.1097/mca.0000000000000644

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Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes

Autor: Simon Redwood, Charles Knight, Krishnaraj S. Rathod, Miles Dalby, Roby Rakhit, Constantinos O'Mahony, Andrew Wragg, Ajay Jain, Pitt Lim, Alexander Sirker, Zoe Astroulakis, Elliot J. Smith, Daniel A. Jones, Philip MacCarthy, Iqbal S. Malik, Sundeep Kalra, Sudheer Koganti, Anthony Mathur

Publikováno v: Journal of the American College of Cardiology. 72:1989-1999

Background A large proportion of patients presenting with non–ST-segment elevation myocardial infarction (NSTEMI) present with multivessel disease (MVD). There is uncertainty in the role of complete coronary revascularization in this group of patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37c0a756aaee5ec3a46420bea390bc3
https://doi.org/10.1016/j.jacc.2018.07.089

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Complete Versus Culprit only Revascularisation in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction: Incidence and Outcomes from the London Heart Attack Group

Autor: Krishnaraj S. Rathod, Roby Rakhit, Charles Knight, Simon Redwood, Andrew Wragg, Constantinos O'Mahony, Miles Dalby, Mark Whitbread, Sundeep Kalra, Iqbal S. Malik, Ajay Jain, Tim Lockie, Alexander Sirker, Anthony Mathur, Sudheer Koganti, Philip MacCarthy, Sam Firoozi, Daniel A. Jones, R. G. Bogle

Publikováno v: Cardiovascular revascularization medicine : including molecular interventions. 21(3)

Background Despite advances in technology, patients with Cardiogenic Shock (CS) presenting with ST-segment myocardial infarction (STEMI) still have a poor prognosis with high mortality rates. A large proportion of these patients have multi-vessel cor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8dbcfa7098592f9193c3e8009a5c92
https://pubmed.ncbi.nlm.nih.gov/32354475

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Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction

Autor: Xiaohong Zhang, Andrea Protti, Ajay M. Shah, Colin E. Murdoch, Alison C. Brewer, Alexander Sirker, Min Zhang, Greta J. Sawyer, Daniel Martin, Celio X.C. Santos

Publikováno v: Sirker, A, Murdoch, C E, Protti, A, Sawyer, G J, Santos, C X C, Martin, D, Zhang, X, Brewer, A C, Zhang, M & Shah, A M 2016, ' Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction ', Journal of Molecular and Cellular Cardiology, vol. 98, pp. 11-17 . https://doi.org/10.1016/j.yjmcc.2016.07.003
Journal of Molecular and Cellular Cardiology

Background Increased reactive oxygen species (ROS) production is involved in the process of adverse cardiac remodeling and development of heart failure after myocardial infarction (MI). NADPH oxidase-2 (Nox2) is a major ROS source within the heart an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca438bd2b8ca3631583c7aa6f5efe6b
https://doi.org/10.1016/j.yjmcc.2016.07.003

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