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Akademický článek
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Autor:
Alexander Si Kai Yong, Ko Hui Tan, Joel Lang Yi Ang, Chiyo Wan Xuan Tan, Jessica Sze Jia Kng, Cyrus Jia Jun Tan, Rachael Hui Kie Soh, Kaicheng Liang
Cellular imaging of thick samples usually requires either physical sectioning or laser scanning microscopy, which are time-consuming and involved. We developed a compact fibre optic-illuminated imaging platform based on microscopy with ultraviolet (U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eedc658cbfb08d30663e70a0faee1cf0
https://doi.org/10.1101/2022.12.28.521919
https://doi.org/10.1101/2022.12.28.521919
Autor:
Emmanuel Eze, Alexander Siegmund
Publikováno v:
Geography and Sustainability, Vol 5, Iss 3, Pp 392-404 (2024)
Increased hazards threatening the United Nations Educational, Scientific and Cultural Organization (UNESCO)-designated sites and endangering cultural heritage and community well-being require attention and action. Considering the pivotal role of UNES
Externí odkaz:
https://doaj.org/article/ae7a4c615f6b41f9b1fa0183068325ec
Autor:
Jacob D. Teeter, Mamun Sarker, Wenchang Lu, Chenggang Tao, Arthur P. Baddorf, Jingsong Huang, Kunlun Hong, Jerry Bernholc, Alexander Sinitskii, An-Ping Li
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-7 (2024)
Abstract Graphene nanoribbons (GNRs) of precise size and shape, critical for controlling electronic properties and future device applications, can be realized via precision synthesis on surfaces using rationally designed molecular precursors. Fluorin
Externí odkaz:
https://doaj.org/article/cee5f067fc0b4e6c9f32e66235bc8481
Autor:
Alexander Siegman, Aaron Shaykevich, Danbee Chae, Isaac Silverman, Sanjay Goel, Radhashree Maitra
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7530-7547 (2024)
The KRAS gene is mutated in approximately 45% of colorectal cancer patients. There are currently very few targeted treatments or therapies equipped to directly inhibit KRAS due to its unusual structural intricacies. Erlotinib, an EGFR inhibitor, has
Externí odkaz:
https://doaj.org/article/08004cdcbccf45a08d50130a8c2da875
Autor:
Elena Poddubskaya, Maria Suntsova, Marina Lyadova, Daniil Luppov, Anastasia Guryanova, Vladimir Lyadov, Andrew Garazha, Maksim Sorokin, Anna Semenova, Vitaly Shatalov, Maria Biakhova, Alexander Simonov, Aleksey Moisseev, Anton Buzdin
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundImmune checkpoint inhibitors (ICIs) treatment have shown high efficacy for about 15 cancer types. However, this therapy is only effective in 20-30% of cancer patients. Thus, the precise biomarkers of ICI response are an urgent need.MethodsW
Externí odkaz:
https://doaj.org/article/f5e235f5965041f5933b00319546e7d2
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103440- (2024)
Summary: Monoclonal antibodies (mAbs) targeting bacterial virulence factors may represent promising therapeutics in the fight against severe bacterial infections. Here, we present an approach for developing human-derived antibodies targeting the type
Externí odkaz:
https://doaj.org/article/8afc04c295aa467c99145a933872eb6a
Autor:
Clare Liddy, Lynn Cooper, Geoff Bellingham, Tracy Deyell, Pablo Ingelmo, Isabella Moroz, Patricia Poulin, Alexander Singer, Gabrielle S. Logan, Regina Visca, Amin Zahrai, Norman Buckley
Publikováno v:
Canadian Journal of Pain, Vol 8, Iss 1 (2024)
Background Wait times at Canadian multidisciplinary pain clinics have been reported as excessive for nearly 2 decades.Aims The aim of this study was to gain insight into the patient experience of waiting for chronic pain specialty care.Methods A cros
Externí odkaz:
https://doaj.org/article/49fc8386b0104442be35b31d982b1b59
Autor:
Alaa Alsalloum, Saleh Alrhmoun, Olga Perik-Zavosdkaia, Marina Fisher, Marina Volynets, Julia Lopatnikova, Roman Perik-Zavodskii, Julia Shevchenko, Julia Philippova, Olga Solovieva, Evgenii Zavjalov, Vasily Kurilin, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The development of T cell receptor-engineered T cells (TCR-T) targeting intracellular antigens is a promising strategy for treating solid tumors; however, the mechanisms underlying their effectiveness remain poorly understood. In this study, we emplo
Externí odkaz:
https://doaj.org/article/77dad727226247d3abacb18938ba3249