Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alexander Schnitzler"'
Autor:
Alexander Schnitzler, Andreas Gratz, Andre Bollacke, Michael Weyrich, Uwe Kuckländer, Bernhard Wünsch, Claudia Götz, Karsten Niefind, Joachim Jose
Publikováno v:
Pharmaceuticals, Vol 11, Iss 1, p 23 (2018)
Human protein kinase CK2 is an emerging target for neoplastic diseases. Potent lead structures for human CK2 inhibitors are derived from dibenzofuranones. Two new derivatives, 7,9-dichloro-1,2-dihydro-8-hydroxy-4-[(4-methoxyphenylamino)-methylene]dib
Externí odkaz:
https://doaj.org/article/e600547616ff4022ba3097e5bc9ea5e6
Autor:
Alexander Schnitzler, Karsten Niefind
Publikováno v:
European journal of medicinal chemistry. 214
The Ser/Thr kinase CK2, a member of the superfamily of eukaryotic protein kinases, has an acidophilic substrate profile with the substrate recognition sequence S/T-D/E-X-D/E, and it is inhibited by polyanionic substances like heparin. The latter, a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1022ae5ba301450036cb13773461cf89
https://pubmed.ncbi.nlm.nih.gov/33571828
https://pubmed.ncbi.nlm.nih.gov/33571828
Autor:
Nicolas Patrick Maria Pauen, Alexander Schnitzler, Christoph van Treeck, Jérôme Frisch, Eric Spinnräker
Publikováno v:
Bauingenieur. 94:37-44
Zusammenfassung Im Vergleich zu anderen produzierenden Industrien stagniert im Bauwesen die Arbeitsproduktivität je Erwerbstätigem seit Jahren. Trotz der in der Praxis zunehmenden digitalen Planung mithilfe von Building Information Modeling (BIM),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a4466a4916bfaa1cbf6e44b59f00aa4
https://doi.org/10.37544/0005-6650-2019-02-23
https://doi.org/10.37544/0005-6650-2019-02-23
Autor:
Markus Pietsch, Kaido Viht, Alexander Schnitzler, Ramesh Ekambaram, Michaela Steinkrüger, Erki Enkvist, Christian Nienberg, Anna Nickelsen, Miriam Lauwers, Joachim Jose, Asko Uri, Karsten Niefind
Publikováno v:
Bioorganic Chemistry. 96:103608
Protein kinase CK2, a heterotetrameric holoenzyme composed of two catalytic chains (CK2α) attached to a homodimer of regulatory subunits (CK2β), is a target for drug development for cancer therapy. Here, we describe the tetraiodobenzimidazole deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f991fde1cdfac6b6e2016e82dcb5e356
https://doi.org/10.1016/j.bioorg.2020.103608
https://doi.org/10.1016/j.bioorg.2020.103608
Autor:
N. R. Skorokhyd, Maciej Masłyk, Alexander Schnitzler, R. R. Panchuk, B. de Pascual-Teresa, Ana Ramos, Claire Coderch, Robert Swider, Karsten Niefind, José María Zapico
Publikováno v:
RSC Advances. 5:72482-72494
A new series of 4,5,6,7-tetrabromobenzotriazole (TBB) derivatives was synthesized and characterized as CK2 inhibitors. They were readily synthesized using a click chemistry approach based on a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65fe95a75016e4fe755a76f66583e956
https://doi.org/10.1039/c5ra12114k
https://doi.org/10.1039/c5ra12114k
Autor:
Claudia Götz, Karsten Niefind, Joachim Jose, Michael Weyrich, Bernhard Wünsch, Uwe Kuckländer, Andreas Gratz, Andre Bollacke, Alexander Schnitzler
Publikováno v:
'Pharmaceuticals ', vol: 11, pages: 23-1-23-24 (2018)
Pharmaceuticals
Pharmaceuticals, Vol 11, Iss 1, p 23 (2018)
Pharmaceuticals; Volume 11; Issue 1; Pages: 23
Pharmaceuticals
Pharmaceuticals, Vol 11, Iss 1, p 23 (2018)
Pharmaceuticals; Volume 11; Issue 1; Pages: 23
Human protein kinase CK2 is an emerging target for neoplastic diseases. Potent lead structures for human CK2 inhibitors are derived from dibenzofuranones. Two new derivatives, 7,9-dichloro-1,2-dihydro-8-hydroxy-4-[(4-methoxyphenylamino)-methylene]dib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707f9c5a5e530f97c727f3a2c9aec034
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:51483
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:51483
Publikováno v:
Protein Kinase CK2 Cellular Function in Normal and Disease States ISBN: 9783319145433
As key components of cellular regulation and signal transduction, eukaryotic protein kinases (EPKs) are strictly regulated. Sophisticated control mechanisms of EPKs are necessary which typically include conformational changes of the enzymes in critic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a512dd50f7f916010962f0a1c545daa9
https://doi.org/10.1007/978-3-319-14544-0_2
https://doi.org/10.1007/978-3-319-14544-0_2
