Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alexander Schering"'
Autor:
Sonja Frimmel, Souska Zandi, Dawei Sun, Zhongyu Zhang, Alexander Schering, Mark I Melhorn, Shintaro Nakao, Ali Hafezi-Moghadam
Publikováno v:
Journal of Ophthalmic & Vision Research, Vol 12, Iss 2, Pp 175-182 (2017)
Purpose: Diabetic retinopathy is a leading cause of vision loss. There is a great need for early diagnosis prior to the occurrence of irreversible structural damages. Expression of endothelial adhesion molecules is observed before the onset of diabet
Externí odkaz:
https://doaj.org/article/07f4068fd4a441cd9742bec6502c4d20
Autor:
Souska Zandi, Shintaro Nakao, Kwang-Hoon Chun, Paolo Fiorina, Dawei Sun, Ryoichi Arita, Ming Zhao, Enoch Kim, Olivier Schueller, Stewart Campbell, Mahdi Taher, Mark Ivan Melhorn, Alexander Schering, Francesca Gatti, Sara Tezza, Fang Xie, Andrea Vergani, Shigeo Yoshida, Keijiro Ishikawa, Muneo Yamaguchi, Fumiyuki Sasaki, Ruth Schmidt-Ullrich, Yasuaki Hata, Hiroshi Enaida, Mitsuko Yuzawa, Takehiko Yokomizo, Young-Bum Kim, Paul Sweetnam, Tatsuro Ishibashi, Ali Hafezi-Moghadam
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1173-1186 (2015)
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying cause is unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics in eyes of aged mice, revealing immune changes in aging. ROCK i
Externí odkaz:
https://doaj.org/article/fe2a70bf023f435d8820d05229083c8e
Autor:
Mitsuko Yuzawa, Ryoichi Arita, Keijiro Ishikawa, Young-Bum Kim, Fumiyuki Sasaki, Hiroshi Enaida, M. I. Melhorn, Enoch Kim, Shigeo Yoshida, Paul Sweetnam, Andrea Vergani, Souska Zandi, Shintaro Nakao, Stewart Campbell, Tatsuro Ishibashi, Alexander Schering, Olivier Schueller, Fang Xie, Yasuaki Hata, Ruth Schmidt-Ullrich, Mahdi Taher, Dawei Sun, Kwang Hoon Chun, Muneo Yamaguchi, Sara Tezza, Francesca Gatti, Ming Zhao, Paolo Fiorina, Takehiko Yokomizo, Ali Hafezi-Moghadam
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1173-1186 (2015)
SummaryAge is a major risk factor in age-related macular degeneration (AMD), but the underlying cause is unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics in eyes of aged mice, revealing immune changes in aging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d503f2ab1c5f115bef04e1a6495cca
Autor:
Yvonne Kienast, Elias K. Loos, Kshitij Srivastava, Christian Klein, Philipp Seidel, Sila Appak, Thomas Wieland, Moritz Felcht, Simone Kutschera, Emmanouil Chavakis, Dorothee Terhardt, Eva Besemfelder, Alexander Schering, Hellmut G. Augustin, Robert Luck, Akiyoshi Uemura, Christiane Vettel, Junhao Hu, Susanne Bartels, Arne Bartol, Sergij Goerdt, Markus Thomas
Publikováno v:
Journal of Clinical Investigation. 122:1991-2005
Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts as a negative regulator of ANG-1/TIE2 signaling during angiogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b9bea6d81d05b73f2e26416fd70429
https://doi.org/10.1172/jci58832
https://doi.org/10.1172/jci58832
Autor:
Mahdi Taher, Souska Zandi, Shintaro Nakao, Yukihiko Mashima, Ali Hafezi-Moghadam, Kousuke Noda, Fang Xie, Dawei Sun, Alexander Schering
Publikováno v:
The American Journal of Pathology. 178:1913-1921
Vascular adhesion protein-1 (VAP-1) contributes to inflammatory and angiogenic diseases, including cancer and age-related macular degeneration. It is expressed in blood vessels and contributes to inflammatory leukocyte recruitment. The cytokines IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9f5905db8b102e3364db2ef39767de
https://doi.org/10.1016/j.ajpath.2011.01.011
https://doi.org/10.1016/j.ajpath.2011.01.011
Autor:
Y. Ito, Nuria Lara-Castillo, Ali Hafezi-Moghadam, Ryoichi Arita, Yasuaki Hata, Dawei Sun, Souska Zandi, Tatsuro Ishibashi, Shuhei Kawahara, Shintaro Nakao, Alexander Schering, M. I. Melhorn
Publikováno v:
Blood. 117:1081-1090
Angio- and lymphangiogenesis are inherently related processes. However, how blood and lymphatic vessels regulate each other is unknown. This work introduces a novel mechanism explaining the temporal and spatial relation of blood and lymphatic vessels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ca69884cf0cf4e2b5f5bf47a4c70d9
https://doi.org/10.1182/blood-2010-02-267427
https://doi.org/10.1182/blood-2010-02-267427
Autor:
Kumiyo Oba, Ri Ichiro Kohno, Yasuaki Hata, Tatsuro Ishibashi, Shintaro Nakao, Yukio Sassa, Alexander Schering, Muneki Miura, Takeshi Kita
Publikováno v:
British Journal of Ophthalmology. 95:261-265
Background/aim Tumour necrosis factor-a (TNFa )i s an inflammatory cytokine that is upregulated in various vitreoretinal diseases including uveitis and diabetic retinopathy. Recently, our studies have indicated that hyalocytes contribute to the patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e787ed8166f9866d25041c2866f6afe5
https://doi.org/10.1136/bjo.2010.190322
https://doi.org/10.1136/bjo.2010.190322
Autor:
Fang Xie, SouskaZandi Zandi, Dawei Sun, Alexander Schering, Shintaro Nakao, Ali Hafezi-Moghadam
Publikováno v:
The FASEB Journal. 24:1532-1540
The need remains great for early diagnosis of diseases. The special structure of the eye provides a unique opportunity for noninvasive light-based imaging of fundus vasculature. To detect endothelial injury at the early and reversible stage of adhesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96969fce3e7d81f8afbf9f6f8a70bc8
https://doi.org/10.1096/fj.09-148981
https://doi.org/10.1096/fj.09-148981
Autor:
Faryan Tayyari, Sonja Frimmel, Ali Hafezi-Moghadam, Alexander Schering, Sepideh Faez, Rebecca C. Garland, Shintaro Nakao, Fang Xie, Souska Zandi, Dawei Sun
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(4)
Uveitis is a systemic immune disease and a common cause of blindness. The eye is an ideal organ for light-based imaging of molecular events underlying vascular and immune diseases. The phospholipid platelet-activating factor (PAF) is an important med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fa9e3f134d1b503379e318ed814b37
https://pubmed.ncbi.nlm.nih.gov/21257713
https://pubmed.ncbi.nlm.nih.gov/21257713
Autor:
Alexander Schering, Ali Hafezi-Moghadam, Souska Zandi, Dawei Sun, Shintaro Nakao, Fang Xie, Ping Liu
There is an urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversible tissue damage. Acute anterior chamber inflammation is the most common form of uveitis and a major cause of vision loss. The proximity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ea7e6f08af734f666a6b483440194b
https://europepmc.org/articles/PMC2893649/
https://europepmc.org/articles/PMC2893649/
