Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alexander Schepsky"'
Autor:
Pakavarin Louphrasitthiphol, Alessia Loffreda, Vivian Pogenberg, Sarah Picaud, Alexander Schepsky, Hans Friedrichsen, Zhiqiang Zeng, Anahita Lashgari, Benjamin Thomas, E. Elizabeth Patton, Matthias Wilmanns, Panagis Filippakopoulos, Jean-Philippe Lambert, Eiríkur Steingrímsson, Davide Mazza, Colin R. Goding
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis. How this is achieved is poorly
Externí odkaz:
https://doaj.org/article/05062f093ad34978985104ce9fcbc2bd
Autor:
Alexander Schepsky, Gunnhildur Asta Traustadottir, Jon Petur Joelsson, Sævar Ingthorsson, Jennifer Kricker, Jon Thor Bergthorsson, Arni Asbjarnarson, Thorkell Gudjonsson, Nina Nupponen, Ana Slipicevic, Fredrik Lehmann, Thorarinn Gudjonsson
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6726-6738 (2020)
Abstract Melphalan flufenamide (hereinafter referred to as “melflufen”) is a peptide‐conjugated drug currently in phase 3 trials for the treatment of relapsed or refractory multiple myeloma. Due to its lipophilic nature, it readily enters cells
Externí odkaz:
https://doaj.org/article/5b8204561d5640db964aa4eb74a5b510
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24064 (2011)
The development of melanocytes is regulated by the tyrosine kinase receptor c-KIT and the basic-helix-loop-helix-leucine zipper transcription factor Mitf. These essential melanocyte survival regulators are also well known oncogenic factors in maligna
Externí odkaz:
https://doaj.org/article/de4fd9baa312403b9a5b17203d28cdcb
Autor:
Vivien Ionasz, Alexander Schepsky, Jon August Stefansson, Margret H. Ogmundsdottir, Valerie Fock, Jade Viarigi, Hilmar Orn Gunnlaugsson, Sigurdur Gudmundsson, Indridi Einar Reynisson, Eiríkur Steingrímsson, Matthias Wilmanns, Vivian Pogenberg
Publikováno v:
Pigment Cell Melanoma Res
Microphthalmia-associated transcription factor (MITF) is a member of the basic helix-loop-helix leucine zipper (bHLH-Zip) family and functions as the master regulator of the melanocytic lineage. MITF-M is the predominant isoform expressed in melanocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34aecc397e5cfbe10bc46ab60faf7e7
https://doi.org/10.1111/pcmr.12721
https://doi.org/10.1111/pcmr.12721
Autor:
Jon G. Jonasson, Erika Morera, Ottar Rolfsson, Bryndis Valdimarsdottir, Bjarni A. Agnarsson, Gunnhildur Asta Traustadottir, Qiong Wang, Sophie Sarah Steinhaeuser, Alexander Schepsky, Thordur Oskarsson, Thorarinn Gudjonsson, Bylgja Hilmarsdottir, Saevar Ingthorsson, Aileen Krueger, Anna Karen Sigurdardottir, Gunhild Mari Mælandsmo, Angela Riedel, Zuzana Budkova
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 100(7)
The tumor microenvironment is increasingly recognized as key player in cancer progression. Investigating heterotypic interactions between cancer cells and their microenvironment is important for understanding how specific cell types support cancer. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9510c5e1e0afb65b4170e69cce2aa83
https://pubmed.ncbi.nlm.nih.gov/32203150
https://pubmed.ncbi.nlm.nih.gov/32203150
Abstract 5205: Melflufen, a peptide-conjugated alkylator, shows efficacy in breast cancer cell lines
Autor:
Jennifer A. Kricker, Thorarinn Gudjonsson, Saevar Ingthorsson, Jon T. Bergthyorsson, Ana Slipicevic, Jon Petur Joelsson, Alexander Schepsky, Gunnhildur Asta Traustadottir, Katrina B. Petursdottir, Thorkell Gudjonsson, Fredrik Lehmann
Publikováno v:
Cancer Research. 80:5205-5205
Introduction: Melflufen is a lipophilic peptide-conjugated alkylator currently in phase 3 trial for the treatment of late stage multiple myeloma. Due to its lipophilic nature it readily enters cells where it is cleaved by peptidases leading to entrap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9246860fca889dd2994f7ffe85c01464
https://doi.org/10.1158/1538-7445.am2020-5205
https://doi.org/10.1158/1538-7445.am2020-5205
Autor:
Vivian Pogenberg, Margret H. Ogmundsdottir, Kristin Bergsteinsdottir, Alexander Schepsky, Eiríkur Steingrímsson, Morlin Milewski, Matthias Wilmanns, Bengt Phung, Viktor Deineko
Publikováno v:
Genes & development 26, 2647-2658 (2012). doi:10.1101/gad.198192.112
Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte development and an important oncogene in melanoma. MITF heterodimeric assembly with related basic helix–loop–helix leucine zipper transcription factors is h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d0c7e7dc2163cc1aa13938b6403cb1
https://doi.org/10.1101/gad.198192.112
https://doi.org/10.1101/gad.198192.112
Autor:
Heinz Arnheiter, Neal G. Copeland, Colin Fletcher, Bryndis K. Gísladóttir, Eiríkur Steingrímsson, Deborah A. Swing, T. Norene O'Sullivan, Christian Praetorius, Jón Hallsteinn Hallsson, Alexander Schepsky, Keren Bismuth, Georg L. Bauer, Nancy A. Jenkins, Julien Debbache, Kristin Bergsteinsdottir, Søren Warming
Publikováno v:
Genetics. 183:581-594
The microphthalmia-associated transcription factor (Mitf) has emerged as an important model for gene regulation in eukaryotic organisms. In vertebrates, it regulates the development of several cell types including melanocytes and has also been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4c2e515cdc1faeb77f2319535a56e1
https://doi.org/10.1534/genetics.109.103945
https://doi.org/10.1534/genetics.109.103945
Autor:
Heinz Arnheiter, Eiríkur Steingrímsson, Benedikta S. Haflidadóttir, Jón Hallsteinn Hallsson, Alexander Schepsky
Publikováno v:
Pigment Cell Research. 20:185-200
The microphthalmia-associated transcription factor (MITF) is a member of the MYC family of basic helix-loop-helix leucine zipper transcription factors. The corresponding gene was initially discovered in the mouse based on mutations which affect the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a092585ae5dfd4ea0ef37071ec9e541
https://doi.org/10.1111/j.1600-0749.2007.00373.x
https://doi.org/10.1111/j.1600-0749.2007.00373.x
Autor:
Eiríkur Steingrímsson, Matthias Wilmanns, Alexander Schepsky, Kristin Bergsteinsdottir, Veronique Pingault, Vivian Pogenberg, Christine Grill, Margret H. Ogmundsdottir
Publikováno v:
Human molecular genetics. 22(21)
The basic-helix–loop–helix-leucine zipper (bHLHZip) protein MITF (microphthalmia-associated transcription factor) is a master regulator of melanocyte development. Mutations in the MITF have been found in patients with the dominantly inherited hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3117fa3337d8d90558810c64b0e9671
https://pubmed.ncbi.nlm.nih.gov/23787126
https://pubmed.ncbi.nlm.nih.gov/23787126