Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexander Samoshkin"'
Autor:
Marino Convertino, Alexander Samoshkin, Chi T Viet, Josee Gauthier, Steven P Li Fraine, Reza Sharif-Naeini, Brian L Schmidt, William Maixner, Luda Diatchenko, Nikolay V Dokholyan
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142826 (2015)
The pharmacological effect of opioids originates, at the cellular level, by their interaction with the μ-opioid receptor (mOR) resulting in the regulation of voltage-gated Ca2+ channels and inwardly rectifying K+ channels that ultimately modulate th
Externí odkaz:
https://doaj.org/article/f37d37398b544f9790034c9b9456470a
Autor:
Alexander Samoshkin, Alexei Arnaoutov, Lars E T Jansen, Ilia Ouspenski, Louis Dye, Tatiana Karpova, James McNally, Mary Dasso, Don W Cleveland, Alexander Strunnikov
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6831 (2009)
Condensins I and II in vertebrates are essential ATP-dependent complexes necessary for chromosome condensation in mitosis. Condensins depletion is known to perturb structure and function of centromeres, however the mechanism of this functional link r
Externí odkaz:
https://doaj.org/article/66fdcfa1740f4cf090bee580246d0dc0
Autor:
Alexander Samoshkin, Jeffrey S. Mogil, Jing Wang, Alexander Linton, Arjun Muralidharan, Marino Convertino, Changyu Jiang, William Maixner, Richard Klares, Ru-Rong Ji, Marjo Piltonen, Nikolay V. Dokholyan, Pavel Gris, Luda Diatchenko
Publikováno v:
British Journal of Pharmacology. 178:2709-2726
Background and purpose The μ-opioid receptor (μ receptor) is the primary target for opioid analgesics. The 7-transmembrane (TM) and 6TM μ receptor isoforms mediate inhibitory and excitatory cellular effects. Here, we developed compounds selective
Autor:
Marino Convertino, Alexander Linton, Ru-Rong Ji, Luda Diatchenko, Qingjian Han, Nikolay V. Dokholyan, Edgar M. Faison, Cheng Zhu, Alexander Samoshkin
Publikováno v:
Proteins
The G-protein-coupled μ-opioid receptor (μ-OR) mediates the majority of analgesia effects for morphine and other pain relievers. Despite extensive studies of its structure and activation mechanisms, the inherently low maturation efficiency of μ-OR
Autor:
Marjo Piltonen, Shannon N Tansley, Loren J. Martin, Concetta Dagostino, Massimo Allegri, Luda Diatchenko, Nehme El-Hachem, Marc Parisien, Jeffrey S. Mogil, Arkady Khoutorsky, Alexander Samoshkin
Publikováno v:
Pain. 160:932-944
Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cel
Autor:
Hiroshi Masumoto, Brenda R. Grimes, Natalay Kouprina, Alexander Samoshkin, William C. Earnshaw, Ruchi Bansal, Artem V. Kononenko, Hee Sheung Lee, Nicholas C.O. Lee, Vladimir Larionov
Publikováno v:
BMC Cancer
Lee, H-S, Lee, N C O, Samoshkin, A, Kononenko, A V, Kouprina, N, Larionov, V, Grimes, B R, Bansal, R, Masumoto, H & Earnshaw, W C 2013, ' A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells ', BMC Cancer, vol. 13, 252 . https://doi.org/10.1186/1471-2407-13-252
Lee, H-S, Lee, N C O, Samoshkin, A, Kononenko, A V, Kouprina, N, Larionov, V, Grimes, B R, Bansal, R, Masumoto, H & Earnshaw, W C 2013, ' A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells ', BMC Cancer, vol. 13, 252 . https://doi.org/10.1186/1471-2407-13-252
Background Aneuploidy is a feature of most cancer cells that is often accompanied by an elevated rate of chromosome mis-segregation termed chromosome instability (CIN). While CIN can act as a driver of cancer genome evolution and tumor progression, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f68d760a0444873d1d6aafe4bba815
Autor:
Gary D. Slade, Charles Knott, Claire Magnussen, Sivaani Sivaselvachandran, Shad B. Smith, Sarasa Tohyama, Joseph H. Gitt, Christos G. Gkogkas, Loren J. Martin, Jean-Sebastien Austin, Joel D. Greenspan, Noosha Yosefpour, Dmitri V. Zaykin, Robert E. Sorge, Richard Ohrbach, William Maixner, Tiffany Cole, Nahum Sonenberg, Andrea G. Nackley, Carolina B. Meloto, Chulmin Cho, Roger B. Fillingim, G. Gregory Neely, Luda Diatchenko, Dustin G. Gibson, Ronald Dubner, Alfredo Ribeiro-da-Silva, Ellen Mir, Susana G. Sotocinal, Alexander Samoshkin, Jeffrey S. Wieskopf, Arkady Khoutorsky, Thang M. Khuong, Jeffrey S. Mogil
Publikováno v:
Martin, L J, Smith, S B, Khoutorsky, A, Magnussen, C A, Samoshkin, A, Sorge, R E, Cho, C, Yosefpour, N, Sivaselvachandran, S, Tohyama, S, Cole, T, Khuong, T M, Mir, E, Gibson, D G, Wieskopf, J S, Sotocinal, S G, Austin, J-S, Meloto, C B, Gitt, J H, Gkogkas, C, Sonenberg, N, Greenspan, J, Fillingim, R B, Ohrbach, R, Slade, G D, Knott, C, Dubner, R, Nackley, A G, Ribeiro-da-Silva, A, Neely, G G, Maixner, W, Zaykin, D V, Mogil, J S & Diatchenko, L 2017, ' Epiregulin and EGFR interactions are involved in pain processing ', Journal of Clinical Investigation, vol. 127, no. 9 . https://doi.org/10.1172/JCI87406
The EGFR belongs to the well-studied ErbB family of receptor tyrosine kinases. EGFR is activated by numerous endogenous ligands that promote cellular growth, proliferation, and tissue regeneration. In the present study, we have demonstrated a role fo
Autor:
Megan A. O’Brien, Ruqiang Xu, Joyce M. Balinang, Seth M. Dever, Pamela E. Knapp, MaryPeace McRae, Kurt F. Hauser, Blair N. Costin, Alexander Samoshkin, Luda Diatchenko, Nazira El-Hage
Publikováno v:
AIDS. 28:19-30
OBJECTIVE We previously examined the expression of specific C-terminal μ-opioid receptor (MOR) splice variants in human central nervous system cell types and HIV-infected brain tissue from individuals with neurocognitive impairment ± HIV encephalit
Autor:
Hiroshi Masumoto, Hee-Sheung Lee, Vladimir Larionov, Indri Erliandri, Megumi Nakano, Haiging Fu, Alexander Samoshkin, Mitsuo Oshimura, Natalay Kouprina, Yuichi Iida, Mirit I. Aladjem, William C. Earnshaw
Publikováno v:
ACS Synthetic Biology. 1:590-601
Human artificial chromosomes (HACs) represent a novel promising episomal system for functional genomics, gene therapy, and synthetic biology. HACs are engineered from natural and synthetic alphoid DNA arrays upon transfection into human cells. The us
Autor:
Nicholas C.O. Lee, William C. Reinhold, Adam Pavlicek, Sudhir Varma, Johanna Schleutker, Paul S. Meltzer, Sean Davis, John Otstot, Natalay Kouprina, Greg Solomon, Hee-Sheung Lee, Alexander Samoshkin, Jung-Hyun Kim, Vladimir Larionov
Publikováno v:
Genes, Chromosomes and Cancer. 51:933-948
Several linkage studies provided evidence for the presence of the hereditary prostate cancer locus, HPCX1, at Xq27-q28. The strongest linkage peak of prostate cancer overlies a variable region of ∼750 kb at Xq27 enriched by segmental duplications (