Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexander S. McColl"'
Autor:
Gaston O. Daumy, Boris A. Chrunyk, Ivan G. Otterness, Michele H. Rosner, Yang Cong, Alexander S. McColl
Publikováno v:
Biochemistry. 39:7092-7099
Protein−protein interactions (PPI) are a ubiquitous mode of transmitting signals in cells and tissues. We are testing a stepwise, generic, structure-driven approach for finding low molecular weight inhibitors of protein−protein interactions. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ea8b073ccd5deed003b8cbb8736347
https://doi.org/10.1021/bi000096+
https://doi.org/10.1021/bi000096+
Autor:
Jason K. Dutra, Jayvardhan Pandit, Hong Wang, Mahmoud N. Mansour, Christine E. Oborski, Binqing Wei, Alexander S. McColl, Theresa J. O’Sullivan, Steven W. Goldstein, Steven Capetta, Stephen Noell, Jane M. Withka, Dorff Peter H, Hou Chen, Thomas N. O'Connell, Felix Vajdos, Ivan Viktorovich Efremov, Kris A. Borzilleri
Publikováno v:
Journal of medicinal chemistry. 55(21)
The aspartyl protease β-secretase, or BACE, has been demonstrated to be a key factor in the proteolytic formation of Aβ-peptide, a major component of plaques in the brains of Alzheimer’s disease (AD) patients, and inhibition of this enzyme has em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cdb9cd7c0141ab1f9f362154dc8116
https://pubmed.ncbi.nlm.nih.gov/22468999
https://pubmed.ncbi.nlm.nih.gov/22468999
Autor:
Hong Wang, Jeffrey A. Pfefferkorn, Matthew C. Griffor, Boris A. Chrunyk, Steven J. Hawrylik, David Price, Vincent Mascitti, Alexander S. McColl, Sung Kim, Cathy Préville, Sanjay Dutta, Sreeman K. Mamidyala, Elnaz Menhaji-Klotz, Timothy A. Subashi, M. G. Finn, Jane M. Withka
Publikováno v:
Journal of the American Chemical Society. 134(4)
The asialoglycoprotein receptor (ASGPR) is a high-capacity galactose-binding receptor expressed on hepatocytes that binds its native substrates with low affinity. More potent ligands are of interest for hepatic delivery of therapeutic agents. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70ca831e0f7af87ca2349fff6419c4c
https://pubmed.ncbi.nlm.nih.gov/22280495
https://pubmed.ncbi.nlm.nih.gov/22280495
Autor:
Alexander S. McColl, Gaston O. Daumy, Michael J. Emery, Kieran F. Geoghegan, William H. Martin
Publikováno v:
Bioconjugate Chemistry. 4:537-544
Periodate in neutral aqueous solution rapidly converts N-terminal Ser or Thr to an alpha-N-glyoxylyl moiety that can serve as the locus for incorporation of a modifying group [Geoghegan, K. F., and Stroh, J. G. (1992) Bioconjugate Chem. 3, 138-146. G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618a4c05bc4719181aba496d20bd8484
https://doi.org/10.1021/bc00024a017
https://doi.org/10.1021/bc00024a017
A nuclear magnetic resonance-based functional assay for nicotinamide adenine dinucleotide synthetase
Publikováno v:
Journal of biomolecular screening. 12(4)
Nicotinamide adenine dinucleotide synthetase (NadE) is an essential enzyme for bacterial pathogens and is thus a promising antibacterial target. It catalyzes the conversion of nicotinic acid adenine dinucleotide to nicotinamide adenine dinucleotide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c6526434ec97780c11dfd5b2a0bb87
https://pubmed.ncbi.nlm.nih.gov/17379856
https://pubmed.ncbi.nlm.nih.gov/17379856
Autor:
Kieran F. Geoghegan, Alexander S. McColl, R.C. Heckel, S.E. Lee, Yang Cong, D.J. Wasilko, Peter S. Mezes, Ivan G. Otterness, Gaston O. Daumy, Thomas R Hynes, Caryl Lane
Publikováno v:
Techniques in Protein Chemistry ISBN: 9780124735576
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e91a660c6ef3f54544e197ed54fc131
https://doi.org/10.1016/s1080-8914(97)80052-x
https://doi.org/10.1016/s1080-8914(97)80052-x
Autor:
Joseph M. Merenda, Ivan G. Otterness, Gaston O. Daumy, Cheryl L. Wilder, Alexander S. McColl, Kieran F. Geoghegan
Publikováno v:
FEBS letters. 278(1)
A biologically active preparation of murine recombinant interleukin-1 beta (mIL-1 beta) from Escherichia coli cell lysates contained tow forms of mIL-1 beta with pI 8.7 and pI 8.1, respectively. Treatment with 0.1 M Tris, pH 8.5, at 37 degrees C for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464e0d62002d5dbd5bdc290c3607a5f5
https://pubmed.ncbi.nlm.nih.gov/1993481
https://pubmed.ncbi.nlm.nih.gov/1993481
Autor:
Alexander S. McColl, Joseph M. Merenda, Ivan G. Otterness, Gaston O. Daumy, Kieran F. Geoghegan, Glenn C. Andrews, Arthur Ernest Franke
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 998:32-42
A murine interleukin-1 alpha (mIL-1 alpha) gene coding for amino acids 115 to 270 of the precursor protein (Lomedico, P.T., Gubler, U., Hellmann, C.P., Dukovich, M., Giri, J.G., Pan, Y.E., Collier, K., Semionow, R., Chua, A.O. and Mizel, S.B. (1984)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3742264735c27d5976cea8a8b0b2ce
https://doi.org/10.1016/0167-4838(89)90115-5
https://doi.org/10.1016/0167-4838(89)90115-5
Publikováno v:
Biochimica et biophysica acta. 967(2)
The polypeptide backbone of human C5a was prepared by recombinant DNA techniques. Standard biochemical analysis guided the protein separation to give a sample of C5a which was deemed homogeneous. However, nuclear magnetic resonance (NMR) studies show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220492b9b3c97b2c302e3003bf0b0434
https://pubmed.ncbi.nlm.nih.gov/3056528
https://pubmed.ncbi.nlm.nih.gov/3056528
Publikováno v:
Chemischer Informationsdienst. 11
Mutants of Pseudomonas testosteroni afford a site-specific aromatic hydroxylation of m-hydroxybenzoic acid giving 2,3-dihydroxybenzoic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5148877c09af3d41952326dba62cf80b
https://doi.org/10.1002/chin.198013194
https://doi.org/10.1002/chin.198013194