Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Alexander S. Keller"'
Autor:
T. C. Stevenson Keller, Christophe Lechauve, Alexander S. Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher, Henry R. Askew Page, Aditi Islam, Zhe Yin Tan, Leon J. DeLalio, Steven Brooks, Poonam Sharma, Kwangseok Hong, Wenhao Xu, Alessandra Simão Padilha, Claire A. Ruddiman, Angela K. Best, Edgar Macal, Daniel B. Kim-Shapiro, George Christ, Zhen Yan, Miriam M. Cortese-Krott, Karina Ricart, Rakesh Patel, Timothy P. Bender, Swapnil K. Sonkusare, Mitchell J. Weiss, Hans Ackerman, Linda Columbus, Brant E. Isakson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
Externí odkaz:
https://doaj.org/article/b9f465340f0741ff838bff1e07d81c95
Autor:
Bruce A. Corliss, Leon J. Delalio, T. C. Stevenson Keller, Alexander S. Keller, Douglas A. Keller, Bruce H. Corliss, Jody M. Beers, Shayn M. Peirce, Brant E. Isakson
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying protein hemoglobin, RB
Externí odkaz:
https://doaj.org/article/c29f96a691244be9b8e6b1c946d50eab
Autor:
Hans Ackerman, Mitchell J. Weiss, Miriam M. Cortese-Krott, Steven E. Brooks, Linda Columbus, T C Steven Keller, Christophe Lechauve, Brant E. Isakson, Alexander S. Keller
Publikováno v:
Physiol Rev
Globin proteins exist in every cell type of the vasculature, from erythrocytes to endothelial cells, vascular smooth muscle cells, and peripheral nerve cells. Many globin subtypes are also expressed in muscle tissues (including cardiac and skeletal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac974cc6e99ce65ba9be4620328912f
https://doi.org/10.1152/physrev.00037.2020
https://doi.org/10.1152/physrev.00037.2020
Autor:
Alexander S. Keller, Claudia Spits
Publikováno v:
Cells, Vol 10, Iss 3246, p 3246 (2021)
Cells
Cells
Human pluripotent stem cells (hPSC) are known to acquire chromosomal abnormalities, which range from point mutations to large copy number changes, including full chromosome aneuploidy. These aberrations have a wide-ranging influence on the state of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0671a6ed423a9513bbae5d22f85a4a53
https://www.mdpi.com/2073-4409/10/11/3246
https://www.mdpi.com/2073-4409/10/11/3246
Autor:
Brant E. Isakson, Alexander S. Keller, Lauren A Biwer, Xiaohong Shu, Daniela Begandt, Linda Columbus, Joshua T. Butcher, T.C. Stevenson Keller
Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide (NO) - a key molecule that can directly (or indirectly) act as a vasodilator and anti-inflammatory mediator. In this review, we examine the structural effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e4d9ce71cbc0b4d59ff6a89b1ed9d6
http://doc.rero.ch/record/331600/files/18_2015_Article_2021.pdf
http://doc.rero.ch/record/331600/files/18_2015_Article_2021.pdf
Autor:
Angela K. Best, T.C. Stevenson Keller, Xiaohong Shu, Claire A. Ruddiman, Miranda E. Good, Yang Yang, Linda Columbus, Alexander S. Keller, Brant E. Isakson
Publikováno v:
Circ Res
Rationale: Resistance arteries and conduit arteries rely on different relative contributions of endothelial-derived hyperpolarization versus nitric oxide to achieve dilatory heterocellular signaling. Anatomically, resistance arteries use myoendotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f303b4dcdabd2c9203ca26e244507195
https://doi.org/10.1161/circresaha.118.313926
https://doi.org/10.1161/circresaha.118.313926
Autor:
Yingnan Lei, Nuša Krivec, Mieke Geens, Karen Sermon, Claudia Spits, Alexander S. Keller, Edouard Couvreu De Deckersberg, Dominika Dziedzicka, Christina Markouli
SummaryThough gains of chromosome 12p13.31 are highly recurrent in hPSC, their impact on differentiation is poorly understood. We identify a reduction in differentiation capacity towards all three germ layers and a subpopulation of residual pluripote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8eed08e6bf9c3ae0f006a2937e1602c
https://doi.org/10.1101/2021.05.22.445238
https://doi.org/10.1101/2021.05.22.445238
Autor:
E. Couvreu De Deckersberg, Alexander S. Keller, Christina Markouli, Claudia Spits, Karen Sermon, Dominika Dziedzicka, Mieke Geens, Alexander Gheldof, Silvie Franck, M Regin
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
We identified a human embryonic stem cell subline that fails to respond to the differentiation cues needed to obtain endoderm derivatives, differentiating instead into extra-embryonic mesoderm. RNA-sequencing analysis showed that the subline has hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4c517e883ca1408727a8b14020543f
https://hdl.handle.net/20.500.14017/4c1e5ff3-ff3d-4226-bce5-8fbdcce29f8b
https://hdl.handle.net/20.500.14017/4c1e5ff3-ff3d-4226-bce5-8fbdcce29f8b
Autor:
Daniel B. Kim-Shapiro, Edgar Macal, Page Hra, Timothy P. Bender, Tan Zy, Poonam Sharma, Aditi Islam, Linda Columbus, George J. Christ, Joshua T. Butcher, Hans Ackerman, Keller Ts, Kwangseok Hong, Angela K. Best, Brás Broseghini-Filho G, Simão Padilha A, Christophe Lechauve, Mitch Weiss, Claire A. Ruddiman, Wenhao Xu, Swapnil K. Sonkusare, Zhen Yan, Steven E. Brooks, Miriam M. Cortese-Krott, Ricart K, Leon J. DeLalio, Alexander S. Keller, Brant E. Isakson, Rakesh P. Patel
Small artery vasodilation in response to hypoxia is essential for matching oxygen supply to tissue oxygen demand. One source of hypoxic dilation via nitric oxide (NO) signaling is nitrite reduction by erythrocytic hemoglobin (α2β2). However, the al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e47474ebc50156dc359dfcbaebc815
https://doi.org/10.1101/2021.02.12.430954
https://doi.org/10.1101/2021.02.12.430954
Autor:
Silvie Franck, Claudia Spits, Mukul Tewary, Mieke Geens, Karen Sermon, Joel Ostblom, Edouard Couvreu De Deckersberg, Laurentijn Tilleman, Dominika Dziedzicka, Laura Prochazka, Filip Van Nieuwerburgh, Alexander S. Keller, Christina Markouli, Peter W. Zandstra
Publikováno v:
SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Low differentiation propensity towards a targeted lineage can significantly hamper the utility of individual human pluripotent stem cell (hPSC) lines in biomedical applications. Here, we use monolayer and micropatterned cell cultures, as well as tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129ae2a71a5533749e427769bdf100f7
https://hdl.handle.net/1854/LU-8701854
https://hdl.handle.net/1854/LU-8701854