Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Alexander S. Hauser"'
Autor:
Shane C. Wright, Aikaterini Motso, Stefania Koutsilieri, Christian M. Beusch, Pierre Sabatier, Alessandro Berghella, Élodie Blondel-Tepaz, Kimberley Mangenot, Ioannis Pittarokoilis, Despoina-Christina Sismanoglou, Christian Le Gouill, Jesper V. Olsen, Roman A. Zubarev, Nevin A. Lambert, Alexander S. Hauser, Michel Bouvier, Volker M. Lauschke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract G protein-coupled receptors are important drug targets that engage and activate signaling transducers in multiple cellular compartments. Delineating therapeutic signaling from signaling associated with adverse events is an important step tow
Externí odkaz:
https://doaj.org/article/87f6a5fc98af40a19909134b0c703db6
Autor:
Hüsün Sheyma Kizilkaya, Kimmie Vestergaard Sørensen, Camilla J. Kibsgaard, Laerke Smidt Gasbjerg, Alexander S. Hauser, Alexander Hovard Sparre-Ulrich, Niels Grarup, Mette M. Rosenkilde
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR) are involved in multiple physiological systems related to glucose metabolism, bone homeostasis and fat deposition. Recent research has surprisingly indicated that both agonist
Externí odkaz:
https://doaj.org/article/576b5caf495a4d74915a5fe12de45fdd
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Purpose: To investigate the trends and progresses in glaucoma research by searching two major clinical trial registries; clinicaltrials.gov, and Australianclinicaltrials.gov.au.Methods: All clinical trials with glaucoma covered by Clinicaltrials.gov,
Externí odkaz:
https://doaj.org/article/6878b2ba42b64d1ebe432aa8da160dfb
Autor:
Peter Lindquist, Jakob S. Madsen, Hans Bräuner-Osborne, Mette M. Rosenkilde, Alexander S. Hauser
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Strong efforts have been placed on understanding the physiological roles and therapeutic potential of the proglucagon peptide hormones including glucagon, GLP-1 and GLP-2. However, little is known about the extent and magnitude of variability in the
Externí odkaz:
https://doaj.org/article/4414c22dd3c8479c97e141d7444d4941
Autor:
Ida Osborn Frandsen, Michael W. Boesgaard, Kimberley Fidom, Alexander S. Hauser, Vignir Isberg, Hans Bräuner-Osborne, Petrine Wellendorph, David E. Gloriam
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Virtual screening offers an efficient alternative to high-throughput screening in the identification of pharmacological tools and lead compounds. Virtual screening is typically based on the matching of target structures or ligand pharmacopho
Externí odkaz:
https://doaj.org/article/87f8aac272544c70b1de0ff93ba5bde1
Autor:
Charlotte Avet, Arturo Mancini, Billy Breton, Christian Le Gouill, Alexander S Hauser, Claire Normand, Hiroyuki Kobayashi, Florence Gross, Mireille Hogue, Viktoriya Lukasheva, Stéphane St-Onge, Marilyn Carrier, Madeleine Héroux, Sandra Morissette, Eric B Fauman, Jean-Philippe Fortin, Stephan Schann, Xavier Leroy, David E Gloriam, Michel Bouvier
Publikováno v:
eLife, Vol 11 (2022)
The recognition that individual GPCRs can activate multiple signaling pathways has raised the possibility of developing drugs selectively targeting therapeutically relevant ones. This requires tools to determine which G proteins and βarrestins are a
Externí odkaz:
https://doaj.org/article/34e18aa1566b4e768be5932a0e81dff7
Autor:
Alexander S Hauser, Charlotte Avet, Claire Normand, Arturo Mancini, Asuka Inoue, Michel Bouvier, David E Gloriam
Publikováno v:
eLife, Vol 11 (2022)
Two-thirds of human hormones and one-third of clinical drugs act on membrane receptors that couple to G proteins to achieve appropriate functional responses. While G protein transducers from literature are annotated in the Guide to Pharmacology datab
Externí odkaz:
https://doaj.org/article/283c3da5e6474bf9a0bac7e3c8a8a7c0
Autor:
Jimmy Caroli, Alibek Mamyrbekov, Kasper Harpsøe, Sahar Gardizi, Linda Dörries, Eshan Ghosh, Alexander S. Hauser, Albert J. Kooistra, David E. Gloriam
Publikováno v:
Nature Chemical Biology. 19:531-535
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea04a20e1924c784f4db40f75d6248a
https://doi.org/10.1038/s41589-023-01292-8
https://doi.org/10.1038/s41589-023-01292-8
Autor:
Josefine U Melchiorsen, Kimmie V Sørensen, Jette Bork-Jensen, Hüsün S Kizilkaya, Lærke S Gasbjerg, Alexander S Hauser, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Anette P Gjesing, Jens J Holst, Torben Hansen, Mette M Rosenkilde, Niels Grarup
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Context Impact of lost GLP-1 receptor function in human physiology. Objective Identify coding nonsynonymous GLP1R variants in Danish individuals to link their in vitro phenotypes and clinical phenotypic associations. Methods We sequenced GLP1R in 8,6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42765a2459edd5eb09d9dd7deb86cd2
https://doi.org/10.1210/clinem/dgad290
https://doi.org/10.1210/clinem/dgad290
Autor:
David Reiner-Link, Alexander S. Hauser
Publikováno v:
BIOspektrum. 28:140-143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a62b812a1d9ab5f00c64b944db970434
https://doi.org/10.1007/s12268-022-1721-x
https://doi.org/10.1007/s12268-022-1721-x