Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alexander S. Brown"'
Autor:
Gabe Quinones, Anthony E. Oro, Stefan M. Pulst, Jessica Magri, Alexander S. Brown, Thomas S. Otis, Pratap Meera
Publikováno v:
Cell Cycle
Spinocerebellar ataxias (SCA) are a genetically heterogeneous family of cerebellar neurodegenerative diseases characterized by abnormal firing of Purkinje neurons and degeneration. We recently demonstrated the slowed firing rates seen in several SCAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5eb8ca0e93dbdf9abdb92d9ef8f0a1
https://europepmc.org/articles/PMC6961678/
https://europepmc.org/articles/PMC6961678/
Autor:
Alexander S. Brown, Lauren P. Shapiro, Matthew P. Scott, Alexandra Essebier, Raul Ayala Davila, Tracey J. Harvey, Michael Piper, Mikael Bodén, Brandon J. Wainwright, James Fraser, Peter Penzes, Oressia Zalucki, Danyon Harkins, Richard M. Gronostajski
Publikováno v:
Cerebellum
Transcriptional regulation plays a central role in controlling neural stem and progenitor cell proliferation and differentiation during neurogenesis. For instance, transcription factors from the nuclear factor I (NFI) family have been shown to co-ord
Autor:
Nicole M. Urman, Anthony E. Oro, C. Yao, Gautam Shankar, Alexander S. Brown, Matthew P. Scott, Jean Y. Tang, Scott X. Atwood, Ervin H. Epstein, A. Mirza, Alexander Lee, Micah A. Fry, Jiang Li, Eunice Y. Lee, Ramon J. Whitson, S. Tyler Hollmig, Sumaira Z. Aasi, Kavita Y. Sarin
Publikováno v:
Nature Medicine. 24:271-281
Hedgehog pathway-dependent cancers can escape Smoothened (SMO) inhibition through mutations in genes encoding canonical hedgehog pathway components; however, around 50% of drug-resistant basal cell carcinomas (BCCs) lack additional variants of these
Autor:
Douglas J. Epstein, Ying-Tao Zhao, James Meyers, Kyoung-Jae Won, Victor Muthu, Shweta Ramdas, Christopher D. Brown, Kevin A. Peterson, Staci M. Rakowiecki, Yao Yao, Alexander S. Brown, Alex M Rohacek
Publikováno v:
Muthu, V, Rohacek, A M, Yao, Y, Rakowiecki, S M, Brown, A S, Zhao, Y-T, Meyers, J, Won, K-J, Ramdas, S, Brown, C D, Peterson, K A & Epstein, D J 2019, ' Genomic architecture of Shh-dependent cochlear morphogenesis ', Development (Cambridge, England), vol. 146, no. 18, 181339 . https://doi.org/10.1242/dev.181339
Development
Development
The mammalian cochlea develops from a ventral outgrowth of the otic vesicle in response to Shh signaling. Mouse embryos lacking Shh or its essential signal transduction components display cochlear agenesis, however, a detailed understanding of the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a12f8d61de574d527ab91a68984a47
https://curis.ku.dk/ws/files/247388696/dev181339.full.pdf
https://curis.ku.dk/ws/files/247388696/dev181339.full.pdf
Autor:
Alexander S. Brown, Jessica Magri, Sharan Paul, Anthony E. Oro, Daniel R. Scoles, Thomas S. Otis, Emma M. Perkins, Stefan M. Pulst, Scott X. Atwood, Ravi Chopra, Banu Altindag, Vikram G. Shakkottai, Pratap Meera, Eric Tarapore, Haoran Huang, Mandy Jackson
Publikováno v:
Brown, A S, Meera, P, Altindag, B, Chopra, R, Perkins, E, Paul, S, Scoles, D R, Tarapore, E, Magri, J, Huang, H, Jackson, M, Shakkottai, V G, Otis, T S, Pulst, S M, Atwood, S X & Oro, A E 2018, ' MTSS1/Src family kinase Dysregulation Underlies Multiple Inherited Ataxias ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1816177115
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 52
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 52
The genetically heterogeneous spinocerebellar ataxias (SCAs) are caused by Purkinje neuron dysfunction and degeneration, but their underlying pathological mechanisms remain elusive. The Src family of nonreceptor tyrosine kinases (SFK) are essential f
Autor:
Alexander S. Brown, Eric Tarapore, Ravi Chopra, Sharan Paul, Scott X. Atwood, Anthony E. Oro, Pratap Meera, Vikram G. Shakkottai, Mandy Jackson, Banu Altindag, Daniel R. Scoles, Emma M. Perkins, Thomas S. Otis, Stefan M. Pulst
The genetically heterogeneous Spinocerebellar ataxias (SCAs) are caused by Purkinje neuron dysfunction and degeneration, but their underlying pathological mechanisms remain elusive. The Src family of non-receptor tyrosine kinases (SFK) are essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4ec477f0b9de0dc342777ffb0168c6
Autor:
Siegen A. McKellar, Sumaira Z. Aasi, A. Mirza, Tyler Hollmig, Nicole M. Urman, Anthony E. Oro, Alexander S. Brown
Publikováno v:
Cell. 176(1-2)
Understanding transcription factor navigation through the nucleus remains critical for developing targeted therapeutics. The GLI1 transcription factor must maintain maximal Hedgehog pathway output in basal cell carcinomas (BCCs), and we have previous
Autor:
YuShan Tu, Richard M. Gronostajski, Tracey J. Harvey, Bryan W. Day, Alexandra Essebier, Mikael Bodén, Raul Ayala Davila, Matthew P. Scott, Michael Piper, Brandon J. Wainwright, James Fraser, Kathleen S. Ensbey, Ameet S. Sengar, Alexander S. Brown
Publikováno v:
Brain structurefunction. 224(2)
Cerebellar granule neurons are the most numerous neuronal subtype in the central nervous system. Within the developing cerebellum, these neurons are derived from a population of progenitor cells found within the external granule layer of the cerebell
Autor:
Alexander S. Brown, Richard M. Gronostajski, Michael Piper, Raul Ayala Davila, Alexandra Essebier, Mikael Bodén, James Fraser, Tracey J. Harvey
Publikováno v:
IBRO Reports. 6:S337-S338
Autor:
A. Mirza, Bruce R. Ruggeri, Tyler Hollmig, Marina Sirota, Craig A. Zificsak, Jon Roffey, Nicole M. Urman, Bruce D. Dorsey, Gregory R. Ott, Sumaira Z. Aasi, Alexander S. Brown, Kavita Y. Sarin, Alexander Lee, Micah A. Fry, Bin Chen, Anthony E. Oro, Ervin H. Epstein, Atul J. Butte, Jean Y. Tang, Mark A. Ator, Scott X. Atwood
Publikováno v:
JCI insight, vol 2, iss 21
Advanced basal cell carcinomas (BCCs) circumvent Smoothened (SMO) inhibition by activating GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required for their survival. Unfortunately, there is a lack of efficacious ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2221d01b990490d52ed807f592c774
https://escholarship.org/uc/item/71j0p898
https://escholarship.org/uc/item/71j0p898