Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection.

Autor: Tiffany Hensley-McBain, Michael C Wu, Jennifer A Manuzak, Ryan K Cheu, Andrew Gustin, Connor B Driscoll, Alexander S Zevin, Charlene J Miller, Ernesto Coronado, Elise Smith, Jean Chang, Michael Gale, Ma Somsouk, Adam D Burgener, Peter W Hunt, Thomas J Hope, Ann C Collier, Nichole R Klatt

Publikováno v: PLoS Pathogens, Vol 15, Iss 4, p e1007672 (2019)

Gastrointestinal (GI) mucosal dysfunction predicts and likely contributes to non-infectious comorbidities and mortality in HIV infection and persists despite antiretroviral therapy. However, the mechanisms underlying this dysfunction remain incomplet

Externí odkaz: https://doaj.org/article/c8db3329e3b74305971fa5b384d2eb98

Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques

Autor: Ryan Cheu, Michael Cartwright, Alexander S. Zevin, Jeremy Smedley, Ernesto Coronado, Mike Fang, Toni M. Gott, Hans Benjamin Hampel, Drew May, Andrew T. Gustin, Jacob Modesitt, Brian Richardson, Solomon Wangari, Nichole R. Klatt, Jennifer A. Manuzak, Mark J. Cameron, Brian Agricola, Cheryl M. Cameron, Elise Smith, Michael Gale, Charlene Miller, Tiffany Hensley-McBain

Publikováno v: Mucosal Immunology. 13:471-480

The diverse bacterial communities that colonize the gastrointestinal tract play an essential role in maintaining immune homeostasis through the production of critical metabolites such as short-chain fatty acids (SCFAs) and this can be disrupted by an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ffc92e0f7c4d7bd3648b6ad4ee1951
https://doi.org/10.1038/s41385-019-0238-1

Sex Work Is Associated With Increased Vaginal Microbiome Diversity in Young Women From Mombasa, Kenya

Autor: Sharmistha Mishra, Nzioki King’ola, Lyle R. McKinnon, Alexander S. Zevin, Peter Gichangi, Sammy Wambua, Michael G. Becker, Aida Sivro, Cheli Kambaran, Nichole R. Klatt, Paul J. McLaren, Marissa Becker, Eve Cheuk, Huiting Ma, Henok Gebrebrhan, Ruth S. Mwatelah

Publikováno v: Journal of acquired immune deficiency syndromes (1999). 85(1)

BACKGROUND Although nonoptimal vaginal bacteria and inflammation have been associated with increased HIV risk, the upstream drivers of these phenotypes are poorly defined in young African women. SETTING Mombasa, Kenya. METHODS We characterized vagina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c9ad6121be14fd34ffb6d18588716d
https://pubmed.ncbi.nlm.nih.gov/32433252

Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection

Autor: Maria Casadellà, Cristina Rodríguez, Maria Luz Calle, Josep Coll, Jorge Carrillo, J Saz, Eugenia Negredo, Muntsa Rocafort, Manuel Crespo, Julià Blanco, Marçal Arumí, Mariona Parera, Ariadna Torrella, Guillem Sirera, Alexander S. Zevin, Yolanda Guillén, Carla Estany, Javier Rivera, Cristina Herrero, Beatriz Mothe, Roger Paredes, Jordi Navarro, Christian Brander, Isabel Bravo, Nichole R. Klatt, Bonaventura Clotet, Marc Noguera-Julian

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Mucosal Immunology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)

Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2831531a55a836dea95e6321a0d9b64
https://ddd.uab.cat/record/224112

Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function

Autor: Brian Agricola, Laura E. Richert-Spuhler, Alexander S. Zevin, Gabriela Patilea, Jacob D. Estes, Elias K. Haddad, Charlene Miller, Rafael Cubas, Tiffany Hensley-McBain, R. Keith Reeves, Jennifer A. Manuzak, Stanley A. Langevin, Jill Gile, Nichole R. Klatt

Publikováno v: The Journal of Immunology. 196:2401-2409

Given the critical role of mucosal surfaces in susceptibility to infection, it is imperative that effective mucosal responses are induced when developing efficacious vaccines and prevention strategies for infection. Modulating the microbiota in the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca73223ddf88ae9f5562e241de2ddaed
https://doi.org/10.4049/jimmunol.1502470