Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Alexander S Pym"'
Autor:
Camus Nimmo, PhD, James Millard, MBBS, Lucy van Dorp, PhD, Kayleen Brien, MSc, Sashen Moodley, BSc, Allison Wolf, MPH, Alison D Grant, ProfPhD, Nesri Padayatchi, ProfPhD, Alexander S Pym, PhD, François Balloux, ProfPhD, Max O'Donnell, MD
Publikováno v:
The Lancet Microbe, Vol 1, Iss 4, Pp e165-e174 (2020)
Summary: Background: Bedaquiline and clofazimine are important drugs in the treatment of drug-resistant tuberculosis and are commonly used across southern Africa, although drug susceptibility testing is not routinely performed. In this study, we did
Externí odkaz:
https://doaj.org/article/a8877c5ec7bd4737835e6429c4f29db7
Autor:
Deeqa Mahamed, Mikael Boulle, Yashica Ganga, Chanelle Mc Arthur, Steven Skroch, Lance Oom, Oana Catinas, Kelly Pillay, Myshnee Naicker, Sanisha Rampersad, Colisile Mathonsi, Jessica Hunter, Emily B Wong, Moosa Suleman, Gopalkrishna Sreejit, Alexander S Pym, Gila Lustig, Alex Sigal
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/44ae2c1724af4e21a31feb70c749ee9b
Autor:
Deeqa Mahamed, Mikael Boulle, Yashica Ganga, Chanelle Mc Arthur, Steven Skroch, Lance Oom, Oana Catinas, Kelly Pillay, Myshnee Naicker, Sanisha Rampersad, Colisile Mathonsi, Jessica Hunter, Emily B Wong, Moosa Suleman, Gopalkrishna Sreejit, Alexander S Pym, Gila Lustig, Alex Sigal
Publikováno v:
eLife, Vol 6 (2017)
A hallmark of pulmonary tuberculosis is the formation of macrophage-rich granulomas. These may restrict Mycobacterium tuberculosis (Mtb) growth, or progress to central necrosis and cavitation, facilitating pathogen growth. To determine factors leadin
Externí odkaz:
https://doaj.org/article/91ed3710575d48488a548fdbc63e7f89
Autor:
Keira A Cohen, Thomas Abeel, Abigail Manson McGuire, Christopher A Desjardins, Vanisha Munsamy, Terrance P Shea, Bruce J Walker, Nonkqubela Bantubani, Deepak V Almeida, Lucia Alvarado, Sinéad B Chapman, Nomonde R Mvelase, Eamon Y Duffy, Michael G Fitzgerald, Pamla Govender, Sharvari Gujja, Susanna Hamilton, Clinton Howarth, Jeffrey D Larimer, Kashmeel Maharaj, Matthew D Pearson, Margaret E Priest, Qiandong Zeng, Nesri Padayatchi, Jacques Grosset, Sarah K Young, Jennifer Wortman, Koleka P Mlisana, Max R O'Donnell, Bruce W Birren, William R Bishai, Alexander S Pym, Ashlee M Earl
Publikováno v:
PLoS Medicine, Vol 12, Iss 9, p e1001880 (2015)
BackgroundThe continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis (TB) identified in Tugela Fe
Externí odkaz:
https://doaj.org/article/a6f052360a9d4e52a13a40b48a41183c
Autor:
Nonkqubela Bantubani, Gaetan Kabera, Catherine Connolly, Roxana Rustomjee, Tarylee Reddy, Ted Cohen, Alexander S Pym
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90868 (2014)
Nosocomial transmission has been implicated as a key factor in the outbreak of extensively drug resistant (XDR) and multidrug-resistant (MDR-TB) tuberculosis at Church of Scotland Hospital (CoSH), in KwaZulu-Natal (KZN), South Africa. The aim of this
Externí odkaz:
https://doaj.org/article/b0b8de7a86f246f887c9eedcf66b9bc1
Autor:
Wilbert Bitter, Edith N G Houben, Daria Bottai, Priscille Brodin, Eric J Brown, Jeffery S Cox, Keith Derbyshire, Sarah M Fortune, Lian-Yong Gao, Jun Liu, Nicolaas C Gey van Pittius, Alexander S Pym, Eric J Rubin, David R Sherman, Stewart T Cole, Roland Brosch
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000507 (2009)
Externí odkaz:
https://doaj.org/article/1efeb760ec434933a447d9ab9dd83d1d
Autor:
Keira A Cohen, Thomas Abeel, Abigail Manson McGuire, Christopher A Desjardins, Vanisha Munsamy, Terrance P Shea, Bruce J Walker, Nonkqubela Bantubani, Deepak V Almeida, Lucia Alvarado, Sinead Chapman, Nomonde R Mvelase, Eamon Y Duffy, Michael G Fitzgerald, Pamla Govender, Sharvari Gujja, Susanna Hamilton, Clint Howarth, Jeffrey D Larimer, Kasmheel Maharaj, Matthew D Pearson, Margaret E Priest, Qiandong Zeng, Nesri Padayatchi, Jacques Grosset, Sarah K Young, Jennifer Wortman, Koleka P Mlisana, Max R O’Donnell, Bruce W Birren, William R Bishai, Alexander S Pym, Ashlee M Earl
Publikováno v:
International Journal of Mycobacteriology, Vol 4, Iss 5, Pp 24-24 (2015)
The largest global outbreak of extensively drug-resistant (XDR) tuberculosis (TB) was identified in Tugela Ferry, KwaZulu-Natal (KZN), South Africa in 2005. The antecedents and timing of the emergence of drug resistance in this fatal epidemic XDR out
Externí odkaz:
https://doaj.org/article/20fbc3a98e734134a6b8e906e19ff3dc
Autor:
Sebastian Gagneux, Marcos V Burgos, Kathryn DeRiemer, Antonio Encisco, Samira Muñoz, Phillip C Hopewell, Peter M Small, Alexander S Pym
Publikováno v:
PLoS Pathogens, Vol 2, Iss 6, p e61 (2006)
Understanding the ecology of drug-resistant pathogens is essential for devising rational programs to preserve the effective lifespan of antimicrobial agents and to abrogate epidemics of drug-resistant organisms. Mathematical models predict that strai
Externí odkaz:
https://doaj.org/article/28982486cfc34d9e9de24f6200fd03f4
Autor:
Alexander S. Pym, Khadija Khan, Timothy R. Sterling, Sashen Moodley, Alison D. Grant, Mahomed-Yunus S. Moosa, Farina Karim, Al Leslie, Naomi F Walker, Yuri van der Heijden, Matilda Mazibuko, Paul T. Elkington
Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befa10a3465f82a6e124f118f27e1e9f
https://doi.org/10.1101/2021.11.15.21265734
https://doi.org/10.1101/2021.11.15.21265734
Autor:
Alexander S. Pym, Juanita Pang, Lucy van Dorp, Arturo Torres Ortiz, Louis Grandjean, James Millard, Nesri Padayatchi, Camus Nimmo, Vegard Eldholm, Alison D. Grant, Francois Balloux, Mislav Acman, Cedric C.S. Tan, Max R. O'Donnell, Ola Brønstad Brynildsrud, Xavier Didelot
Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline into TB drug regimens has improved treatment outcomes, but this advance is threatened by the emergence of strains ofMycobacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6460e417c9f541fe248c37954d4d474c
https://doi.org/10.1101/2020.10.06.328799
https://doi.org/10.1101/2020.10.06.328799