Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Alexander S Powers"'
Autor:
Mengyuan Xu, Torben Neelands, Alexander S Powers, Yan Liu, Steven D Miller, Grigore D Pintilie, J Du Bois, Ron O Dror, Wah Chiu, Merritt Maduke
Publikováno v:
eLife, Vol 12 (2024)
CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion homeostasis in many different tissues. Among the nine mammalian CLC homologs, CLC-2 is uniquely activated by hyperpolarization, rather than depolarization,
Externí odkaz:
https://doaj.org/article/ff8936247b544286b1d7a57aab5b1a3c
Autor:
Rohini S. Ople, Nokomis Ramos-Gonzalez, Qiongyu Li, Briana L. Sobecks, Deniz Aydin, Alexander S. Powers, Abdelfattah Faouzi, Benjamin J. Polacco, Sarah M. Bernhard, Kevin Appourchaux, Sashrik Sribhashyam, Shainnel O. Eans, Bowen A. Tsai, Ron O. Dror, Balazs R. Varga, Haoqing Wang, Ruth Hüttenhain, Jay P. McLaughlin, Susruta Majumdar
Publikováno v:
ACS Central Science, Vol 10, Iss 8, Pp 1490-1503 (2024)
Externí odkaz:
https://doaj.org/article/85002e8675b5414c9f0b93723260a5ff
Autor:
Kaiming Zhang, Naoki Horikoshi, Shanshan Li, Alexander S. Powers, Mikhail A. Hameedi, Grigore D. Pintilie, Hee-Don Chae, Yousuf A. Khan, Carl-Mikael Suomivuori, Ron O. Dror, Kathleen M. Sakamoto, Wah Chiu, Soichi Wakatsuki
Publikováno v:
ACS Central Science, Vol 8, Iss 2, Pp 214-222 (2022)
Externí odkaz:
https://doaj.org/article/65bfa553069248ed93809a76bca79c14
Autor:
Kaavya Krishna Kumar, Michael J. Robertson, Elina Thadhani, Haoqing Wang, Carl-Mikael Suomivuori, Alexander S. Powers, Lipin Ji, Spyros P. Nikas, Ron O. Dror, Asuka Inoue, Alexandros Makriyannis, Georgios Skiniotis, Brian Kobilka
Publikováno v:
Nature Communications. 14
Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number of therapeutically relevant physiological responses. Hence, understanding the structural and functional consequen
Autor:
Alexander S. Powers, Vi Pham, Wessel A. C. Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W. Barnes, Patrick M. Sexton, Steven M. Paul, Arthur Christopoulos, David M. Thal, Christian C. Felder, Celine Valant, Ron O. Dror
Publikováno v:
Nature Chemical Biology.
A drug’s selectivity for target receptors is essential to its therapeutic utility, but achieving selectivity between similar receptors is challenging. The serendipitous discovery of ligands that stimulate target receptors more strongly than closely
Autor:
Alexander S. Powers, Vi Pham, Wessel A. C. Burger, Geoff Thompson, Yianni Laloudakis, Nicholas W. Barnes, Patrick M. Sexton, Steven M. Paul, Arthur Christopoulos, David M. Thal, Christian C. Felder, Celine Valant, Ron O. Dror
Publikováno v:
Nature Chemical Biology. 19:529-529
Autor:
Alexander S. Powers, Vi Pham, Celine Valant, David Thal, Arthur Christopoulos, Steven M. Paul, Christian C. Felder, Ron O. Dror
Publikováno v:
Biological Psychiatry. 91:S331
Autor:
Margaux M. Pinney, Alexander S. Powers, Tzanko Doukov, James S. Fraser, Justin T Biel, Daniel Herschlag, Filip Yabukarski
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52
How enzymes achieve their enormous rate enhancements remains a central question in biology, and our understanding to date has impacted drug development, influenced enzyme design, and deepened our appreciation of evolutionary processes. While enzymes
Autor:
Ron O. Dror, Rachael Kretsch, Yifan Cheng, Tara Arvedson, Alexander S. Powers, Shane Gonen, Christian B. Billesbølle, Simon Schneider, Aashish Manglik, Caleigh M. Azumaya
Publikováno v:
Nature, vol 586, iss 7831
Nature
Nature
The serum iron level in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing ferroportin internalization and degradation1. Aberrant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea016a96ef6df3f74bd07bd640f67d05
https://escholarship.org/uc/item/77g2k8b4
https://escholarship.org/uc/item/77g2k8b4
Autor:
Augustine Chemparathy, Mary J. Clark, Lau Tk, Scott A. Hollingsworth, Alexander S. Powers, Nicolas Villanueva, Julia A. Belk, Tynan Je, Joseph M. Paggi, Roger K. Sunahara, Ron O. Dror
Over the past fifty years, tremendous effort has been devoted to computational methods for predicting properties of ligands that bind macromolecular targets, a problem critical to rational drug design. Such methods generally fall into two categories:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c252f0c4a04c8c8d43a15111391e2b20
https://doi.org/10.1101/2020.06.01.128181
https://doi.org/10.1101/2020.06.01.128181