Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alexander S Leonard"'
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1006886 (2019)
The self-assembly of proteins into protein quaternary structures is of fundamental importance to many biological processes, and protein misassembly is responsible for a wide range of proteopathic diseases. In recent years, abstract lattice models of
Externí odkaz:
https://doaj.org/article/373d859ee3134cd28b55a49c016a453a
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Association testing between molecular phenotypes and genomic variants can help to understand how genotype affects phenotype. RNA sequencing provides access to molecular phenotypes such as gene expression and alternative splicing w
Externí odkaz:
https://doaj.org/article/6f8f480dbd024064ad076edc3d62f943
Autor:
Xena Marie Mapel, Naveen Kumar Kadri, Alexander S. Leonard, Qiongyu He, Audald Lloret-Villas, Meenu Bhati, Maya Hiltpold, Hubert Pausch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Breeding bulls are well suited to investigate inherited variation in male fertility because they are genotyped and their reproductive success is monitored through semen analyses and thousands of artificial inseminations. However, functional
Externí odkaz:
https://doaj.org/article/4e9432c4ac32434888c08e1bec982656
Autor:
Xena Marie Mapel, Naveen Kumar Kadri, Alexander S. Leonard, Qiongyu He, Audald Lloret-Villas, Meenu Bhati, Maya Hiltpold, Hubert Pausch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/32391ae90a1347d395b47b47e92d0815
Publikováno v:
Genome Biology, 24 (1)
Background Several models and algorithms have been proposed to build pangenomes from multiple input assemblies, but their impact on variant representation, and consequently downstream analyses, is largely unknown. Results We create multi-species supe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609ec6915b9c840becc1f5ef91e2fbd7
https://hdl.handle.net/20.500.11850/613247
https://hdl.handle.net/20.500.11850/613247
Publikováno v:
Genetics Selection Evolution, 55
Background Low-pass sequencing followed by sequence variant genotype imputation is an alternative to the routine microarray-based genotyping in cattle. However, the impact of haplotype reference panels and their interplay with the coverage of low-pas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e98a340876220819b6442bacaf212b
https://doi.org/10.1186/s12711-023-00809-y
https://doi.org/10.1186/s12711-023-00809-y
Autor:
Adéla Nosková, Chao Li, Xiaolong Wang, Alexander S. Leonard, Hubert Pausch, Naveen Kumar Kadri
The branch point sequence is a degenerate intronic heptamer required for the assembly of the spliceosome during pre-mRNA splicing. Disruption of this motif may promote alternative splicing and eventually cause phenotype variation. Despite its functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ae87932895e59c70c6fad7b10f661bc
https://doi.org/10.1101/2023.03.27.534366
https://doi.org/10.1101/2023.03.27.534366
Autor:
Chao Li, Yujiang Wu, Bingchun Chen, Yudong Cai, Jiazhong Guo, Alexander S Leonard, Peter Kalds, Shiwei Zhou, Jingchen Zhang, Ping Zhou, Shangqu Gan, Ting Jia, Tianchun Pu, Langda Suo, Yan Li, Ke Zhang, Lan Li, Myagmarsuren Purevdorj, Xihong Wang, Ming Li, Yu Wang, Yao Liu, Shuhong Huang, Tad Sonstegard, Ming-Shan Wang, Stephen Kemp, Hubert Pausch, Yulin Chen, Jian-Lin Han, Yu Jiang, Xiaolong Wang
Publikováno v:
Molecular Biology and Evolution, 39 (12)
Understanding the genetic mechanism of how animals adapt to extreme conditions is fundamental to determine the relationship between molecular evolution and changing environments. Goat is one of the first domesticated species and has evolved rapidly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befb1d60099ae178c64706da1e981eaa
https://pubmed.ncbi.nlm.nih.gov/36382357
https://pubmed.ncbi.nlm.nih.gov/36382357
Autor:
Timothy P. L. Smith, Hubert Pausch, C. Herrera, Michael P. Heaton, Derek M. Bickhart, Kristen L. Kuhn, Benjamin D. Rosen, Brian L. Vander Ley, Danang Crysnanto, Alexander S. Leonard, Zih-Hua Fang, Heinrich Bollwein
Publikováno v:
Nature Communications, 13 (1)
Advantages of pangenomes over linear reference assemblies for genome research have recently been established. However, potential effects of sequence platform and assembly approach, or of combining assemblies created by different approaches, on pangen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a8d23a9a650ad7c1153a765948a2e
https://doi.org/10.1038/s41467-022-30680-2
https://doi.org/10.1038/s41467-022-30680-2
Autor:
Alexander S, Leonard, Danang, Crysnanto, Zih-Hua, Fang, Michael P, Heaton, Brian L, Vander Ley, Carolina, Herrera, Heinrich, Bollwein, Derek M, Bickhart, Kristen L, Kuhn, Timothy P L, Smith, Benjamin D, Rosen, Hubert, Pausch
Publikováno v:
Nature communications. 13(1)
Advantages of pangenomes over linear reference assemblies for genome research have recently been established. However, potential effects of sequence platform and assembly approach, or of combining assemblies created by different approaches, on pangen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c392a910eaef5712d4c9b0f2f9571a27
https://pubmed.ncbi.nlm.nih.gov/35641504
https://pubmed.ncbi.nlm.nih.gov/35641504