Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Alexander S Arseniev"'
Autor:
Vladislav A Lushpa, Marina V Goncharuk, Irina A Talyzina, Alexander S Arseniev, Eduard V Bocharov, Konstantin S Mineev, Sergey A Goncharuk
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0304997 (2024)
Toll-like receptors (TLRs) are key players in the innate immune system. Despite the great efforts in TLR structural biology, today we know the spatial structures of only four human TLR intracellular TIR domains. All of them belong to one of five subf
Externí odkaz:
https://doaj.org/article/9761a2e62c224787ad9499a872968cd1
Autor:
Sergey A Goncharuk, Lilya E Artemieva, Valentin M Tabakmakher, Alexander S Arseniev, Konstantin S Mineev
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0206244 (2018)
RIP2, one of the RIP kinases, interacts with p75 neurotrophin receptor, regulating the neuron survival, and with NOD1 and NOD2 proteins, causing the innate immune response against gram-negative and gram-positive bacteria via its caspase recruitment d
Externí odkaz:
https://doaj.org/article/bae2fe1d403e46c68ebd879a1dca9b36
Autor:
Marina V. Goncharuk, Nadezhda S. Baleeva, Dmitry E. Nolde, Alexey S. Gavrikov, Alexey V. Mishin, Alexander S. Mishin, Andrey Y. Sosorev, Alexander S. Arseniev, Sergey A. Goncharuk, Valentin I. Borshchevskiy, Roman G. Efremov, Konstantin S. Mineev, Mikhail S. Baranov
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Structural analyses guide the rational design of mutant fluorogen-activating proteins with enhanced fluorescence.
Externí odkaz:
https://doaj.org/article/9f5e4001803e45c99f3b5822fd1097f3
Autor:
Ekaterina N. Grafskaia, Elizaveta R. Pavlova, Ivan A. Latsis, Maja V. Malakhova, Dmitrii V. Ivchenkov, Pavel V. Bashkirov, Erik F. Kot, Konstantin S. Mineev, Alexander S. Arseniev, Dmitry V. Klinov, Vassili N. Lazarev
Publikováno v:
Materials & Design, Vol 224, Iss , Pp 111364- (2022)
The number of infections caused by antibiotic-resistant pathogens is increasing alarmingly every year and will continue to grow. Antimicrobial peptides (AMPs) are considered new therapeutic agents for the effective combat against infectious diseases.
Externí odkaz:
https://doaj.org/article/173efa149e7440e38205a7555417109a
Autor:
Vladislav A. Lushpa, Marina V. Goncharuk, Cong Lin, Arthur O. Zalevsky, Irina A. Talyzina, Aleksandra P. Luginina, Daniil D. Vakhrameev, Mikhail B. Shevtsov, Sergey A. Goncharuk, Alexander S. Arseniev, Valentin I. Borshchevskiy, Xiaohui Wang, Konstantin S. Mineev
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appe
Externí odkaz:
https://doaj.org/article/ba1903b9028f4b788d2c7b76bc761832
Autor:
Alexey I. Kuzmenkov, Steve Peigneur, Joshua A. Nasburg, Konstantin S. Mineev, Maxim V. Nikolaev, Ernesto Lopes Pinheiro-Junior, Alexander S. Arseniev, Heike Wulff, Jan Tytgat, Alexander A. Vassilevski
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Apamin is often cited as one of the few substances selectively acting on small-conductance Ca2+-activated potassium channels (KCa2). However, published pharmacological and structural data remain controversial. Here, we investigated the molecular phar
Externí odkaz:
https://doaj.org/article/03250e942dc5484ca71aad07a5e99041
Autor:
Sergey A. Goncharuk, Lilya E. Artemieva, Kirill D. Nadezhdin, Alexander S. Arseniev, Konstantin S. Mineev
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear.
Externí odkaz:
https://doaj.org/article/93e81a0ed52f4a949f2c31ba9f7ec4c9
Autor:
Vladislav V. Motov, Erik F. Kot, Alexandra V. Shabalkina, Sergey A. Goncharuk, Alexander S. Arseniev, Marina V. Goncharuk, Konstantin S. Mineev
Publikováno v:
Journal of Biomolecular NMR. 77:15-24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad984f051d006e3fde4a4733a78c8629
https://doi.org/10.1007/s10858-022-00408-x
https://doi.org/10.1007/s10858-022-00408-x
Autor:
Sergey L. Deev, Alexander S. Paramonov, Tatyana S. Shestakova, Igor A. Khalymbadzha, Oleg N. Chupakhin, Julia O. Subbotina, Oleg S. Eltsov, Pavel A. Slepukhin, Vladimir L. Rusinov, Alexander S. Arseniev, Zakhar O. Shenkarev
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2535-2548 (2017)
Determining the accurate chemical structures of synthesized compounds is essential for biomedical studies and computer-assisted drug design. The unequivocal determination of N-adamantylation or N-arylation site(s) in nitrogen-rich heterocycles, chara
Externí odkaz:
https://doaj.org/article/521f1f61d3474495a26c7f41618b4e52
Autor:
Anatoly S. Urban, Konstantin V. Pavlov, Anna V. Kamynina, Ivan S. Okhrimenko, Alexander S. Arseniev, Eduard V. Bocharov
Publikováno v:
Molecules, Vol 26, Iss 10, p 2897 (2021)
Alzheimer’s disease is the most common type of neurodegenerative disease in the world. Genetic evidence strongly suggests that aberrant generation, aggregation, and/or clearance of neurotoxic amyloid-β peptides (Aβ) triggers the disease. Aβ accu
Externí odkaz:
https://doaj.org/article/467b0090289a49c7a051faa36381a146