Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Alexander S, Paramonov"'
Autor:
Ekaterina N. Lyukmanova, Maxim L. Bychkov, Andrei M. Chernikov, Ilya D. Kukushkin, Dmitrii S. Kulbatskii, Sergey V. Shabelnikov, Mikhail A. Shulepko, Ran Zhao, Wenxiao Guo, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev, Alexander S. Paramonov
Publikováno v:
Marine Drugs, Vol 22, Iss 11, p 488 (2024)
Three-finger proteins (TFPs), or Ly6/uPAR proteins, are characterized by the beta-structural LU domain containing three protruding “fingers” and stabilized by four conserved disulfide bonds. TFPs were initially characterized as snake alpha-neurot
Externí odkaz:
https://doaj.org/article/cbdd90c4476b4696a151b0459a9e1974
Autor:
Barbara Z. Eletskaya, Anton F. Mironov, Ilya V. Fateev, Maria Ya. Berzina, Konstantin V. Antonov, Olga S. Smirnova, Alexandra B. Zatsepina, Alexandra O. Arnautova, Yulia A. Abramchik, Alexander S. Paramonov, Alexey L. Kayushin, Anastasia L. Khandazhinskaya, Elena S. Matyugina, Sergey N. Kochetkov, Anatoly I. Miroshnikov, Igor A. Mikhailopulo, Roman S. Esipov, Irina D. Konstantinova
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 798 (2024)
Enzymatic transglycosylation of the fleximer base 4-(4-aminopyridine-3-yl)-1H-pyrazole using recombinant E. coli purine nucleoside phosphorylase (PNP) resulted in the formation of “non-typical” minor products of the reaction. In addition to “ty
Externí odkaz:
https://doaj.org/article/6dc5ba4973204c2f85cf40e3a5e85b6f
Autor:
Ilya V. Fateev, Sobirdjan A. Sasmakov, Jaloliddin M. Abdurakhmanov, Abdukhakim A. Ziyaev, Shukhrat Sh. Khasanov, Farkhod B. Eshboev, Oybek N. Ashirov, Valeriya D. Frolova, Barbara Z. Eletskaya, Olga S. Smirnova, Maria Ya. Berzina, Alexandra O. Arnautova, Yulia A. Abramchik, Maria A. Kostromina, Alexey L. Kayushin, Konstantin V. Antonov, Alexander S. Paramonov, Valeria L. Andronova, Georgiy A. Galegov, Roman S. Esipov, Shakhnoz S. Azimova, Anatoly I. Miroshnikov, Irina D. Konstantinova
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 745 (2024)
1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-tria
Externí odkaz:
https://doaj.org/article/ebd7c06da9b2400790c2af906ba90ef2
Autor:
Zakhar O. Shenkarev, Yuri M. Chesnokov, Maxim M. Zaigraev, Anton O. Chugunov, Dmitrii S. Kulbatskii, Milita V. Kocharovskaya, Alexander S. Paramonov, Maxim L. Bychkov, Mikhail A. Shulepko, Dmitry E. Nolde, Roman A. Kamyshinsky, Evgeniy O. Yablokov, Alexey S. Ivanov, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
The membrane plays a key role in the interaction of non-conventional neurotoxins with the nicotinic receptors.
Externí odkaz:
https://doaj.org/article/54654b9e8be64f4eba0aad318a544d08
Autor:
Pavel A. Mironov, Alexander S. Paramonov, Olesya V. Reznikova, Victoria N. Safronova, Pavel V. Panteleev, Ilia A. Bolosov, Tatiana V. Ovchinnikova, Zakhar O. Shenkarev
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 332 (2024)
Capitellacin is the β-hairpin membrane-active cationic antimicrobial peptide from the marine polychaeta Capitella teleta. Capitellacin exhibits antibacterial activity, including against drug-resistant strains. To gain insight into the mechanism of c
Externí odkaz:
https://doaj.org/article/4f11ec4017154912a397387fa578ed5e
Autor:
Ekaterina N. Lyukmanova, Pavel A. Mironov, Dmitrii S. Kulbatskii, Mikhail A. Shulepko, Alexander S. Paramonov, Elizaveta M. Chernaya, Yulia A. Logashina, Yaroslav A. Andreev, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev
Publikováno v:
Toxins, Vol 15, Iss 6, p 378 (2023)
Phα1β (PnTx3–6) is a neurotoxin from the spider Phoneutria nigriventer venom, originally identified as an antagonist of two ion channels involved in nociception: N-type voltage-gated calcium channel (CaV2.2) and TRPA1. In animal models, Phα1β a
Externí odkaz:
https://doaj.org/article/f4d10ab60deb48d7b5091e7ada0f2188
Autor:
Maxim L. Bychkov, Mikhail A. Shulepko, Olga V. Shlepova, Dmitrii S. Kulbatskii, Irina A. Chulina, Alexander S. Paramonov, Ludmila K. Baidakova, Viatcheslav N. Azev, Sergey G. Koshelev, Mikhail P. Kirpichnikov, Zakhar O. Shenkarev, Ekaterina N. Lyukmanova
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR), participating in control of cancer cell growth. Previously we showed, that a recombin
Externí odkaz:
https://doaj.org/article/4ea1ae5dc8d1418182e8d7e2d15ebd4d
Autor:
Alexander S. Paramonov, Mikhail A. Shulepko, Alexey M. Makhonin, Maxim L. Bychkov, Dmitrii S. Kulbatskii, Andrey M. Chernikov, Mikhail Yu. Myshkin, Sergey V. Shabelnikov, Zakhar O. Shenkarev, Mikhail P. Kirpichnikov, Ekaterina N. Lyukmanova
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 503 (2022)
Three-finger proteins (TFPs) are small proteins with characteristic three-finger β-structural fold stabilized by the system of conserved disulfide bonds. These proteins have been found in organisms from different taxonomic groups and perform various
Externí odkaz:
https://doaj.org/article/c9dc58cc334d4852948d18e54962e1f7
Autor:
Maxim L. Bychkov, Artem V. Kirichenko, Irina N. Mikhaylova, Alexander S. Paramonov, Evgeny V. Yastremsky, Mikhail P. Kirpichnikov, Mikhail A. Shulepko, Ekaterina N. Lyukmanova
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 660 (2022)
Metastatic melanoma is a highly malignant tumor. Melanoma cells release extracellular vesicles (EVs), which contribute to the growth, metastasis, and malignancy of neighboring cells by transfer of tumor-promoting miRNAs, mRNA, and proteins. Melanoma
Externí odkaz:
https://doaj.org/article/3d3334bbbbac4cdf98d941a02d580fc8
Autor:
Sergey L. Deev, Alexander S. Paramonov, Tatyana S. Shestakova, Igor A. Khalymbadzha, Oleg N. Chupakhin, Julia O. Subbotina, Oleg S. Eltsov, Pavel A. Slepukhin, Vladimir L. Rusinov, Alexander S. Arseniev, Zakhar O. Shenkarev
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2535-2548 (2017)
Determining the accurate chemical structures of synthesized compounds is essential for biomedical studies and computer-assisted drug design. The unequivocal determination of N-adamantylation or N-arylation site(s) in nitrogen-rich heterocycles, chara
Externí odkaz:
https://doaj.org/article/521f1f61d3474495a26c7f41618b4e52