Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alexander Richard Liam Cecil"'
Autor:
Apostolia Maria Tsimberidou, Cara Haymaker, Franck Alexandre Silva, Simin Kiany, Kemal Haque, Lucy Coe, Carrie Cartwright, Helen Berryman, Graciela M. Nogueras-Gonzalez, James Dow, David Vining, Alexander Richard Liam Cecil, Henry H. Vo, Elisabeth A. Bone, Ignacio I. Wistuba, Philip A. Beer, Hilary McElwaine-Johnn
Publikováno v:
Clinical Cancer Research. 27:3584-3594
Purpose: Inhibition of histone deacetylase 6 (HDAC6) is predicted to deliver both direct antitumor activity and modulation of the antitumor immune response. This study describes the development of a novel HDAC6 inhibitor. Patients and Methods: KA2507
Autor:
Kemal Haque, Loretta J. Nastoupil, Jason R. Westin, Letitia Lensun, Michael Wang, Sattva S. Neelapu, Hilary McElwaine-Johnn, Felipe Samaniego, Hun Ju Lee, James Dow, Nathan Fowler, Alexander Richard Liam Cecil, Richard E. Davis, Andrew David Whale, Elisabeth A. Bone, Fredrick B. Hagemeister, Philip A Beer, Franck Alexandre Silva
Publikováno v:
Leukemialymphoma. 62(14)
PI3-kinase p110δ is mainly expressed in lymphocytes and is an attractive therapeutic target in B cell lymphomas. Targeting p110β may further suppress tumor growth and overcome escape mechanisms. KA2237 is an oral, potent, dual p110β/p110δ inhibit
Autor:
Sattva S. Neelapu, Penny Ward, James Dow, Fredrick B. Hagemeister, Franck Alexandre Silva, Duncan McHale, Nathan Fowler, Stephen J. Shuttleworth, Hun Ju Lee, Jason R. Westin, Alexander Richard Liam Cecil, Michael Wang, Philip A. Beer, Felipe Samaniego, Arash Yavari, Loretta J. Nastoupil, Eric Davis
Publikováno v:
Blood. 134:4099-4099
Introduction: Despite therapeutic advances, there remains a considerable need for novel therapies for B-cell lymphomas. Although a high proportion of patients (pts) show response to initial therapy, many fail to achieve durable remissions and experie
Autor:
Satoko Maeda, Alexander Yurek-George, Helen L. Rogers, Alexander Richard Liam Cecil, Graham Packham, Arasu Ganesan, Minoru Yoshida, Fay Habens, Alex Hon Kit Mo, Shijun Wen
Publikováno v:
Journal of Medicinal Chemistry. 50:5720-5726
The FK228 and spiruchostatin bicyclic depsipeptide natural products are among the most potent histone deacetylase (HDAC) inhibitors known. Although FK228 is in advanced clinical trials, the complexity of the natural products has precluded mechanistic
Publikováno v:
Organic Letters. 4:3715-3718
[reaction: see text] cis-Solamin (1) and its diastereoisomer 14 have been synthesized in 13 steps using the diastereoselective permanganate-promoted oxidative cyclization of 1,5-dienes to create the tetrahydrofuran diol core. Notably, no protecting g
Publikováno v:
ARKIVOC, Vol 2001, Iss 11, Pp 49-57 (2002)
A model study directed towards the synthesis of the Annonaceous acetogenin cis-solamin (1) is reported. The key step in the synthesis involved the permanganate-promoted oxidative cyclisation of ethyl (E)-7-methylocta-2,6-dienoate (7) to afford a tetr
Autor:
Thomas James Hill, Cyrille Davy Tomassi, Rebecca Harrison, Alexander Richard Liam Cecil, Helen L. Rogers, Stephen Shuttleworth, Franck Alexandre Silva, Paul A. Townsend
Publisher Summary In addition to small molecule therapeutics, a number of biological therapies that regulate Th17 cell activity have been discovered over the past decade. Researchers at Schering Corp. have disclosed the identification of antibody- an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0446e7fdf2064efa9ef485753ec41c4c
https://doi.org/10.1016/b978-0-12-381290-2.00003-3
https://doi.org/10.1016/b978-0-12-381290-2.00003-3
Autor:
Thomas James Hill, Helen L. Rogers, Franck Alexandre Silva, Paul A. Townsend, Cyrille Davy Tomassi, Stephen Shuttleworth, Alexander Richard Liam Cecil
Publikováno v:
Progress in Medicinal Chemistry ISBN: 9780444533586
Publisher Summary The phosphoinositide 3-kinases (PI3Ks) constitute a family of lipid kinases involved in the regulation of a network of signal transduction pathways that control a range of cellular processes. A number of ATP-competitive, small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde492d1d4d14ad84f8cfb21eaeb782a
https://doi.org/10.1016/s0079-6468(09)04803-6
https://doi.org/10.1016/s0079-6468(09)04803-6
Autor:
Alexander Yurek-George, Alexander Richard Liam Cecil, Alex Hon Kit Mo, Shijun Wen, Helen Rogers, Fay Habens, Satoko Maeda, Minoru Yoshida, Graham Packham, A. Ganesan
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 23, p5720-5726, 7p