Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alexander R. Keeble"'
Autor:
Andrea L. Dimet-Wiley, Christine M. Latham, Camille R. Brightwell, Harshini Neelakantan, Alexander R. Keeble, Nicholas T. Thomas, Haley Noehren, Christopher S. Fry, Stanley J. Watowich
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Human hallmarks of sarcopenia include muscle weakness and a blunted response to exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and promote the regenerative capacity of aged muscle, thus offering a promising
Externí odkaz:
https://doaj.org/article/bd2c80f1e7bf42fd9e877971c7a909b7
Autor:
Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evi
Externí odkaz:
https://doaj.org/article/0bc07f083e994c3a999d215e49a6bcfe
Autor:
Camille R. Brightwell, Christine M. Latham, Nicholas T. Thomas, Alexander R. Keeble, Kevin A. Murach, Christopher S. Fry
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Multinuclear muscle fibers are the most voluminous cells in skeletal muscle and the primary drivers of growth in response to loading. Outside the muscle fiber, however, is a diversity of mononuclear cell types that reside in the extracellular matrix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f5a78c54f52368a0f9f5505f56b919
https://pubmed.ncbi.nlm.nih.gov/35876284
https://pubmed.ncbi.nlm.nih.gov/35876284
Autor:
Alexander R. Keeble, Camille R. Brightwell, Christine M. Latham, Nicholas T. Thomas, C. Brooks Mobley, Kevin A. Murach, Darren L. Johnson, Brian Noehren, Christopher S. Fry
Publikováno v:
The American Journal of Sports Medicine. 51:81-96
Background: Anterior cruciate ligament (ACL) tear (ACLT) leads to protracted quadriceps muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to injury and loading. Regulation of quadriceps molecular protein synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f299071197d6e43dd593fabea67be4e
https://doi.org/10.1177/03635465221135769
https://doi.org/10.1177/03635465221135769
Autor:
Colleen F. McKenna, Amadeo F. Salvador, Alexander R. Keeble, Naiman A. Khan, Michael De Lisio, Adam R. Konopka, Scott A. Paluska, Nicholas A. Burd
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 133(3)
Skeletal muscle aging is a multidimensional pathology of atrophy, reduced strength, and oxidative damage. Although some molecular targets may mediate both hypertrophic and oxidative adaptations in muscle, their responsiveness in humans and relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d7867964013141c3d3a704b0fb79f9
https://pubmed.ncbi.nlm.nih.gov/35834627
https://pubmed.ncbi.nlm.nih.gov/35834627
Autor:
Cory M Dungan, Camille R Brightwell, Yuan Wen, Christopher J Zdunek, Christine M Latham, Nicholas T Thomas, Alyaa M Zagzoog, Benjamin D Brightwell, Georgia L VonLehmden, Alexander R Keeble, Stanley J Watowich, Kevin A Murach, Christopher S Fry
Publikováno v:
Function (Oxford, England). 3(4)
Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Progressive weighted wheel running (PoWeR) is a simple, voluntary, low-cost, high-volume endurance/resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16c5491a66570e5b9429a4ed459ac18
https://pubmed.ncbi.nlm.nih.gov/35774589
https://pubmed.ncbi.nlm.nih.gov/35774589
Decrements In Anabolic Signaling And Protein Synthesis Potentiates ACL Tear Resultant Muscle Atrophy
Autor:
Alexander R. Keeble, Camille R. Brightwell, Darren L. Johnson, Brian Noehren, Christopher S. Fry
Publikováno v:
Medicine & Science in Sports & Exercise. 54:627-627
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::939936dacf616571709ad4b0c14ee659
https://doi.org/10.1249/01.mss.0000882944.66370.44
https://doi.org/10.1249/01.mss.0000882944.66370.44
Autor:
R Clay Bunn, Reuben Adatorwovor, Rebecca R Smith, Philip D Ray, Sarah E Fields, Alexander R Keeble, Christopher S Fry, Sasidhar Uppuganti, Jeffry S Nyman, John L Fowlkes, Evangelia Kalaitzoglou
Publikováno v:
JBMR Plus, Vol 7, Iss 11, Pp n/a-n/a (2023)
ABSTRACT Type 1 diabetes (T1D) is associated with low bone and muscle mass, increased fracture risk, and impaired skeletal muscle function. Myostatin, a myokine that is systemically elevated in humans with T1D, negatively regulates muscle mass and bo
Externí odkaz:
https://doaj.org/article/92100dade6de4c38b7555d341607541a