Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Alexander R. A. Anderson"'
Autor:
Sadegh Marzban, Sonal Srivastava, Sharon Kartika, Rafael Bravo, Rachel Safriel, Aidan Zarski, Alexander R. A. Anderson, Christine H. Chung, Antonio L. Amelio, Jeffrey West
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Direct observation of tumor-immune interactions is unlikely in tumors with currently available technology, but computational simulations based on clinical data can provide insight to test hypotheses. It is hypothesized that patterns of colla
Externí odkaz:
https://doaj.org/article/1d33d803ec3e4aebb7843c05d07fd3d5
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Sandhya Prabhakaran, Ottilie Swinyard, Robbert J. C. Slebos, Gunjan Mandal, Eoghan Mulholland, Noemi Andor, Andriy Marusyk, Simon Leedham, Jose R. Conejo-Garcia, Christine H. Chung, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Interest in spatial omics is on the rise, but generation of highly multiplexed images remains challenging, due to cost, expertise, methodical constraints, and access to technology. An alternative approach is to register collections of whole
Externí odkaz:
https://doaj.org/article/27aa67cd79b24cdf8baff050f7387c85
Autor:
Jeffrey West, Frederika Rentzeperis, Casey Adam, Rafael Bravo, Kimberly A. Luddy, Mark Robertson-Tessi, Alexander R. A. Anderson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMetabolism plays a complex role in the evolution of cancerous tumors, including inducing a multifaceted effect on the immune system to aid immune escape. Immune escape is, by definition, a collective phenomenon by requiring the presence o
Externí odkaz:
https://doaj.org/article/ebd312f46cc14f4ba2f015ce8bb9125f
Autor:
Maximilian A. R. Strobl, Jill Gallaher, Jeffrey West, Mark Robertson-Tessi, Philip K. Maini, Alexander R. A. Anderson
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-18 (2022)
Strobl et al. develop an agent-based spatial model of drug resistance in tumour cells under adaptive therapy. Using this model, they investigate how the tumour’s spatial architecture impacts intratumoural competitive dynamics of drug-sensitive vs.
Externí odkaz:
https://doaj.org/article/6398a24b99384ae086f2c9a62bb96631
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, Jeffrey West, Margarida P. Neves, Sara Yakub Hasan, Eszter Lakatos, Pierre Martinez, William C. H. Cross, Marnix Jansen, Manuel Rodriguez-Justo, Christopher J. Whelan, Andrea Sottoriva, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.
Externí odkaz:
https://doaj.org/article/dec007baa85d4e4e91b6bac2af9bca15
Autor:
Jeffrey West, Ryan O. Schenck, Chandler Gatenbee, Mark Robertson-Tessi, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Some cancers occur in spatially constrained tissues such as the mammary gland, and how the morphological features influence the evolution of the cancer is unclear. Here, the authors use mathematical modeling to study the question of competition for s
Externí odkaz:
https://doaj.org/article/34e86c8a277e4ad28a7be94d4546747f
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-4 (2019)
Abstract Background High throughput sequence data has provided in depth means of molecular characterization of populations. When recorded at numerous time steps, such data can reveal the evolutionary dynamics of the population under study by tracking
Externí odkaz:
https://doaj.org/article/59d617c25fc844599af23a187be6c18a
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009348 (2021)
Intra-tumour heterogeneity is a leading cause of treatment failure and disease progression in cancer. While genetic mutations have long been accepted as a primary mechanism of generating this heterogeneity, the role of phenotypic plasticity is becomi
Externí odkaz:
https://doaj.org/article/d6c120fed11b4ebeb8bb0479a0ce7d3f
Autor:
Daniel Nichol, Joseph Rutter, Christopher Bryant, Andrea M. Hujer, Sai Lek, Mark D. Adams, Peter Jeavons, Alexander R. A. Anderson, Robert A. Bonomo, Jacob G. Scott
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The evolution of resistance to an antibiotic can render bacteria more susceptible, or more resistant, to a second antibiotic. Here, Nichol et al. provide evidence that the final outcome can be fairly stochastic and depends on the shape of the evoluti
Externí odkaz:
https://doaj.org/article/fcd27466c5b448a4a8dd0543dc7be5c4
Publikováno v:
Trends in Cell Biology. 33:300-311
In this opinion, we highlight agent-based modeling as a key tool for exploration of cell-cell and cell-environment interactions that drive cancer progression, therapeutic resistance, and metastasis. These biological phenomena are particularly suited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c20c32561ff56379229560699917488
https://doi.org/10.1016/j.tcb.2022.10.006
https://doi.org/10.1016/j.tcb.2022.10.006