Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alexander R Hobby"'
Autor:
Thomas E. Sharp, III, BA, Hajime Kubo, PhD, Remus M. Berretta, BS, Timothy Starosta, BS, Markus Wallner, MD, PhD, Giana J. Schena, BS, Alexander R. Hobby, BS, Daohai Yu, PhD, Danielle M. Trappanese, PhD, Jon C. George, MD, Jeffery D. Molkentin, PhD, Steven R. Houser, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 669-683 (2017)
Inotropic support is often required to stabilize the hemodynamics of patients with acute decompensated heart failure; while efficacious, it has a history of leading to lethal arrhythmias and/or exacerbating contractile and energetic insufficiencies.
Externí odkaz:
https://doaj.org/article/dd3c3f7a8fed47668b3c56e6c1ad9062
Autor:
Deborah M Eaton, Remus M Berretta, Jacqueline E Lynch, Joshua G Travers, Kathleen C Woulfe, Ryan D Pfeiffer, Michelle L Hulke, Alexander R Hobby, Giana Schena, Jaslyn P Johnson, Markus Wallner, Nathan R Tucker, Timothy A McKinsey, Marla R Wolfson, Steven R Houser
Publikováno v:
Circulation. 144
Introduction: Approximately 50% of all heart failure (HF) diagnoses can be classified as HF with preserved ejection fraction (HFpEF), which has no FDA approved therapies. HFpEF is more prevalent in females compared to males, but the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2981644644f17732bcdc8bff808d5c4
https://doi.org/10.1161/circ.144.suppl_1.8955
https://doi.org/10.1161/circ.144.suppl_1.8955
Autor:
Timothy A. McKinsey, Jaslyn Johnson, Kathleen C. Woulfe, Giana Schena, Steven R. Houser, Jacqueline E Lynch, Joshua G Travers, Alexander R Hobby, Deborah M Eaton, M. Wallner, Marla R. Wolfson, Remus M. Berretta
Publikováno v:
Circulation Research. 129
Rationale: Heart Failure with preserved Ejection Fraction (HFpEF) accounts for approximately 50% of all HF diagnoses with no FDA approved therapies. HFpEF is more prevalent in females versus males, but the mechanisms driving the development of HFpEF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303b5ed8eec01aa83fd7156b9c4644ce
https://doi.org/10.1161/res.129.suppl_1.p411
https://doi.org/10.1161/res.129.suppl_1.p411
Autor:
Timothy A. McKinsey, Sadia Mohsin, Keith A. Koch, Alexander R. Hobby, Alaina L. Headrick, Yijun Yang, Deborah M Eaton, Hajime Kubo, Yinfei Tan, Justin Kurian, Eric Feldsott, Mohsin Khan, Stefania Gallucci, Steven R. Houser, Remus M. Berretta, Marcello Rubino
Publikováno v:
Am J Physiol Heart Circ Physiol
Acute damage to the heart, as in the case of myocardial infarction (MI), triggers a robust inflammatory response to the sterile injury that is part of a complex and highly organized wound-healing process. Cortical bone stem cell (CBSC) therapy after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400504f7faf13b513876b41b336bb171
https://pubmed.ncbi.nlm.nih.gov/34415185
https://pubmed.ncbi.nlm.nih.gov/34415185
Autor:
Giulia Borghetti, Eric Feldsott, Thomas E. Sharp rd, Steven R. Houser, Sadia Mohsin, Remus M. Berretta, Alexander R. Hobby
Publikováno v:
Am J Physiol Heart Circ Physiol
Ischemic heart diseases such as myocardial infarction (MI) are the largest contributors to cardiovascular disease worldwide. The resulting cardiac cell death impairs function of the heart and can lead to heart failure and death. Reperfusion of the is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9538af5bd29543461185b925fc13191
https://doi.org/10.1152/ajpheart.00144.2019
https://doi.org/10.1152/ajpheart.00144.2019
Autor:
Giana Schena, Steven R. Houser, Danielle M. Trappanese, Daohai Yu, Jon C. George, Jeffery D. Molkentin, Hajime Kubo, Tim Starosta, Remus M. Berretta, Alexander R. Hobby, Markus Wallner, Thomas E. Sharp
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 669-683 (2017)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • Acute protein kinase A α (PKCα) inhibition with ruboxistaurin reduces heart size post-myocardial infarction. • Acute PKCα inhibition with ruboxistaurin increases contractility post-myocardial infarction. • P
Highlights • Acute protein kinase A α (PKCα) inhibition with ruboxistaurin reduces heart size post-myocardial infarction. • Acute PKCα inhibition with ruboxistaurin increases contractility post-myocardial infarction. • P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6732927aa6f50eb927b8ed0bcd5b35c8
http://www.sciencedirect.com/science/article/pii/S2452302X17301559
http://www.sciencedirect.com/science/article/pii/S2452302X17301559
Autor:
Sadia Mohsin, Giulia Borghetti, Remus M. Berretta, Eric Feldsott, Steven R. Houser, Alexander R. Hobby, Deborah M Eaton, Hajime Kubo
Publikováno v:
Circulation Research. 125
Ischemic heart diseases like myocardial infarction are the largest contributors to cardiovascular disease world-wide. The resulting cardiac cell death impairs function of the heart and can lead to heart failure and death. Re-perfusion of the ischemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2976594873b577135437f5369ac87c4
https://doi.org/10.1161/res.125.suppl_1.707
https://doi.org/10.1161/res.125.suppl_1.707
Publikováno v:
Behavioural Brain Research. 295:35-44
Alcoholism afflicts 1 in 13 US adults, and comorbidity with depression is common. Levels of serotonin (5-HT) metabolites in alcoholic or depressed humans and rat strains are lower compared to healthy counterparts. Rats bred for ethanol (EtOH) prefere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c182fd5d2ac8792374cb089785179847
https://doi.org/10.1016/j.bbr.2015.06.013
https://doi.org/10.1016/j.bbr.2015.06.013
Autor:
Eric Feldsott, Sadia Mohsin, Steven R. Houser, Hajime Kubo, Alexander R. Hobby, Thomas E. Sharp, Remus M. Berretta
Publikováno v:
Circulation Research. 123
Rationale: Cortical-bone derived stem cells (CBSCs) improve cardiac pump function and reduce scar size after myocardial infarction (MI) compared to Cardiac-Derived and Mesenchymal Stem Cells. However, the mechanism for these improved outcomes is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bc3ef771c9aa930d6aaf65478f20171
https://doi.org/10.1161/res.123.suppl_1.249
https://doi.org/10.1161/res.123.suppl_1.249
Autor:
Steven R. Houser, Hydel Christopher, Joanne Donnelly, Giana Schena, Alexander R. Hobby, Hajime Kubo, Eric T. Choi, Yijun Yang, Polina Gross, Remus M. Berretta, Jaslyn Johnson, Eric Feldsot, Thomas E. Sharp, Sadia Mohsin
Publikováno v:
Circulation Research. 123
Previously, we have shown that treatments of cortical bone derived stem cells (CBSCs) reduce ventricular remodeling and improve cardiac functions in both mouse and pig myocardial infarction (MI) models. The goals of the present study were to isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbf4fd85e5df110f79dcfc88dad09b33
https://doi.org/10.1161/res.123.suppl_1.336
https://doi.org/10.1161/res.123.suppl_1.336