Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alexander R A Szojka"'
Autor:
Alexander R A Szojka, Colleen N Moore, Yan Liang, Stephen H J Andrews, Melanie Kunze, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249513 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0248292.].
Externí odkaz:
https://doaj.org/article/f3cb232a82c44b9eb75210acb0f9f538
Autor:
Alexander R A Szojka, Colleen N Moore, Yan Liang, Stephen H J Andrews, Melanie Kunze, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248292 (2021)
Low oxygen and mechanical loading may play roles in regulating the fibrocartilaginous phenotype of the human inner meniscus, but their combination in engineered tissues remains unstudied. Here, we investigated how continuous low oxygen ("hypoxia") co
Externí odkaz:
https://doaj.org/article/a081f5cedfb645bab934725ca31e1033
Autor:
Aillette Mulet-Sierra, Mark Sommerfeldt, Xiaoyi Lan, Alexander R A Szojka, Adetola B Adesida, Hoda Elkhenany, Melanie Kunze, Nadr M. Jomha, Yan Liang
Publikováno v:
Tissue Engineering Part A. 27:914-928
Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to form the mechanically responsive matrices of joint tissues, including the menisci of the knee joint. The purpose of this study is to assess BMSC's potential to engineer meniscus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcc31c910160e6dd2afdd710002c5d7
https://doi.org/10.1089/ten.tea.2020.0183
https://doi.org/10.1089/ten.tea.2020.0183
Autor:
Alexander R. A. Szojka, David Xinzheyang Li, Malou E. J. Sopcak, Zhiyao Ma, Melanie Kunze, Aillette Mulet-Sierra, Samer M. Adeeb, Lindsey Westover, Nadr M. Jomha, Adetola B. Adesida
Publikováno v:
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Meniscus fibrochondrocytes (MFCs) experience simultaneous hypoxia and mechanical loading in the knee joint. Experimental conditions based on these aspects of the native MFC environment may have promising applications in human meniscus tissue engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47268eb86edb8f70647fbce0d1ec272b
https://pubmed.ncbi.nlm.nih.gov/34540817
https://pubmed.ncbi.nlm.nih.gov/34540817
Autor:
Dinara Zhalmuratova, Katherine Ting-Ting Yu, Hyun-Joong Chung, David S. Nobes, Chun Il Kim, Alexander R A Szojka, Darren H. Freed, Adetola B Adesida, Stephen H. J. Andrews, Thanh-Giang La
Publikováno v:
ACS Applied Materials & Interfaces. 11:33323-33335
An ex vivo heart perfusion device preserves the donor heart in a warm beating state during transfer between extraction and implantation surgeries. One of the current challenges includes the use of rigid and noncompliant plastic tubes, which causes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5f9455b02207c76c5fc179e014a320
https://doi.org/10.1021/acsami.9b10524
https://doi.org/10.1021/acsami.9b10524
Autor:
Aillette Mulet-Sierra, Nadr M. Jomha, Alexander R A Szojka, Yan Liang, Melanie Kunze, Victoria Goncalves, Adetola B Adesida, Samia Rahman
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
ObjectiveArticular cartilage of the knee joint is avascular, exists under a low oxygen tension microenvironment, and does not self-heal when injured. Human infrapatellar fat pad-sourced mesenchymal stem cells (IFP-MSC) are an arthroscopically accessi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89437cf358f417ebe89d02b0fb560fe7
https://pubmed.ncbi.nlm.nih.gov/34381784
https://pubmed.ncbi.nlm.nih.gov/34381784
Autor:
Colleen N Moore, Alexander R A Szojka, Nadr M. Jomha, Rita de Cássia Marqueti, Yan Liang, Adetola B Adesida, Esra J N Erkut, Melanie Kunze, Aillette Mulet-Sierra
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research SocietyREFERENCES. 40(2)
Adult human meniscus fibrocartilage is avascular and nonhealing after injury. Meniscus tissue engineering aims to replace injured meniscus with lab-grown fibrocartilage. Dynamic culture systems may be necessary to generate fibrocartilage of sufficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3717f5f21e90792ca224afa5866467d7
https://pubmed.ncbi.nlm.nih.gov/33788325
https://pubmed.ncbi.nlm.nih.gov/33788325
Autor:
Adetola B Adesida, Yan Liang, Alexander R A Szojka, Melanie Kunze, Aillette Mulet-Sierra, Enaam Idrees
Publikováno v:
Annals of biomedical engineering. 48(3)
Decellularized matrix (DCM) derived from native tissues may be a promising supporting material to induce cellular differentiation by sequestered bioactive factors. However, no previous study has investigated the use of human meniscus-derived DCM to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec34652cb9f99732484421109db9abc8
https://pubmed.ncbi.nlm.nih.gov/31147805
https://pubmed.ncbi.nlm.nih.gov/31147805
Autor:
D. Li, Melanie Kunze, Aillette Mulet-Sierra, Adetola B Adesida, Rita de Cássia Marqueti, Clayton W Molter, Alexander R A Szojka, Yan Liang, Nadr M. Jomha
Publikováno v:
Journal of Tissue Engineering, Vol 12 (2021)
Journal of Tissue Engineering
Journal of Tissue Engineering
This study investigates the transcriptome response of meniscus fibrochondrocytes (MFCs) to the low oxygen and mechanical loading signals experienced in the knee joint using a model system. We hypothesized that short term exposure to the combined trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88005ba79f4f18403383290f22f633f4
https://doi.org/10.1177/2041731421990842
https://doi.org/10.1177/2041731421990842
Hypoxia and TGF-β3 Synergistically Mediate Inner Meniscus-Like Matrix Formation by Fibrochondrocytes
Autor:
Nadr M. Jomha, Alexander R A Szojka, Adetola B Adesida, Enaam Idrees, Colleen N Moore, Aillette Mulet-Sierra, Melanie Kunze, Brayden D Lyons, Yan Liang
Publikováno v:
Tissue engineering. Part A. 25(5-6)
The interactions of hypoxia and TGF-β3 in aggregates of human meniscus fibrochondrocytes are synergistic in nature, suggesting combinatorial strategies using these factors are promising for tissue engineering the inner meniscus regions. Hypoxia alon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916e1e3cf00c2861b7ee71b352f0de7a
https://pubmed.ncbi.nlm.nih.gov/30343640
https://pubmed.ncbi.nlm.nih.gov/30343640