Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Alexander R, Horswill"'
Publikováno v:
mSphere, Vol 9, Iss 5 (2024)
ABSTRACT Biofilm formation is an important virulence factor for methicillin-resistant Staphylococcus aureus (MRSA). The extracellular matrix of MRSA biofilms contains significant amounts of double-stranded DNA that hold the biofilm together. MRSA cel
Externí odkaz:
https://doaj.org/article/8acbfc998f9e4a118fe14231acb220e5
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTStaphylococcus aureus is a Gram-positive pathogen responsible for the majority of skin and soft tissue infections (SSTIs). S. aureus colonizes the anterior nares of approximately 20%–30% of the population and transiently colonizes the skin,
Externí odkaz:
https://doaj.org/article/00a2500699c840828e6396f85ae0bf72
Autor:
Heidi A. Crosby, Klara Keim, Jakub M. Kwiecinski, Christophe J. Langouët-Astrié, Kaori Oshima, Wells B. LaRivière, Eric P. Schmidt, Alexander R. Horswill
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTStaphylococcus aureus is one of the leading causes of hospital-acquired infections, many of which begin following attachment and accumulation on indwelling medical devices or diseased tissue. These infections are often linked to the establish
Externí odkaz:
https://doaj.org/article/58e55729bb694669b833e2b8a927e904
Autor:
Krista B. Mills, Joseph J. Maciag, Can Wang, John A. Crawford, Timothy J. Enroth, Klara C. Keim, Yves F. Dufrêne, D. Ashley Robinson, Paul D. Fey, Andrew B. Herr, Alexander R. Horswill
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114022- (2024)
Summary: Staphylococcus aureus causes the majority of skin and soft tissue infections, but this pathogen only transiently colonizes healthy skin. However, this transient skin exposure enables S. aureus to transition to infection. The initial adhesion
Externí odkaz:
https://doaj.org/article/2ebfbddde1c54212aebe1e6dc23bb64a
Autor:
Katrin Schilcher, Morgan M Severn, Christian Jenul, Young-Saeng C Avina, Rebecca A Keogh, Alexander R Horswill
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002451 (2024)
Lipoproteins of the opportunistic pathogen Staphylococcus aureus play a crucial role in various cellular processes and host interactions. Consisting of a protein and a lipid moiety, they support nutrient acquisition and anchor the protein to the bact
Externí odkaz:
https://doaj.org/article/d4eff5b776f74c0692cc03063a86d52b
Autor:
Reid V. Wilkening, Christophe Langouët-Astrié, Morgan M. Severn, Michael J. Federle, Alexander R. Horswill
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113332- (2023)
Summary: Streptococcus pyogenes is an obligate human pathobiont associated with many disease states. Here, we present a model of S. pyogenes infection using intact murine epithelium. We were able to perform RNA sequencing to evaluate genetic changes
Externí odkaz:
https://doaj.org/article/fb285cde18a945b88366bd3990b99199
Autor:
Janna L. Crossley, Sonya Ostashevskaya-Gohstand, Stefano Comazzetto, Jessica S. Hook, Lei Guo, Neda Vishlaghi, Conan Juan, Lin Xu, Alexander R. Horswill, Gerta Hoxhaj, Jessica G. Moreland, Robert J. Tower, Benjamin Levi
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that unde
Externí odkaz:
https://doaj.org/article/de41bdacaa51470f9d19876b0d0fa043
Autor:
Michael R. Williams, Michelle D. Bagood, Timothy J. Enroth, Zoie L. Bunch, Nina Jiang, Edward Liu, Samia Almoughrabie, Shadi Khalil, Fengwu Li, Samantha Brinton, Nadja B. Cech, Alexander R. Horswill, Richard L. Gallo
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113024- (2023)
Summary: Staphylococcus epidermidis is a common microbe on human skin and has beneficial functions in the skin microbiome. However, under conditions of allergic inflammation, the abundance of S. epidermidis increases, establishing potential danger to
Externí odkaz:
https://doaj.org/article/7c1be9ed35b640a88dd2ccdb553058c2
Autor:
Madeline S. Akbari, Rebecca A. Keogh, Jana N. Radin, Yamil Sanchez-Rosario, Michael D. L. Johnson, Alexander R. Horswill, Thomas E. Kehl-Fie, Lindsey R. Burcham, Kelly S. Doran
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Group B Streptococcus (GBS) is a Gram-positive pathobiont that can cause adverse health outcomes in neonates and vulnerable adult populations. GBS is one of the most frequently isolated bacteria from diabetic (Db) wound infections but is rar
Externí odkaz:
https://doaj.org/article/59765f8d8fce4ae7915a1c7020cab55a
Autor:
James F. Colbert, Joshua M. Kirsch, Christopher L. Erzen, Christophe J. Langouët-Astrié, Grace E. Thompson, Sarah A. McMurtry, Jennifer M. Kofonow, Charles E. Robertson, Elizabeth J. Kovacs, Ryan C. Sullivan, Joseph A. Hippensteel, Namrata V. Sawant, Nicole J. De Nisco, Bruce D. McCollister, Robert S. Schwartz, Alexander R. Horswill, Daniel N. Frank, Breck A. Duerkop, Eric P. Schmidt
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly.
Externí odkaz:
https://doaj.org/article/3534f0ab7eb1418a8befb8cb4e008912