Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alexander R, Harris"'
Publikováno v:
The Lancet Regional Health. Americas, Vol 27, Iss , Pp 100614- (2023)
Externí odkaz:
https://doaj.org/article/dad8a550e2224dac90575a079ca8a823
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Background Regenerative medicine has the potential to treat genetic disorders and replace damaged or missing tissue. The use of donor or animal tissue raises many well-known issues, including limited tissue availability, the possibility of r
Externí odkaz:
https://doaj.org/article/6f19dbee32dd4a5199577e76f753c983
Publikováno v:
Micromachines, Vol 14, Iss 4, p 722 (2023)
Electrodes are used in vivo for chemical sensing, electrophysiological recording, and stimulation of tissue. The electrode configuration used in vivo is often optimised for a specific anatomy and biological or clinical outcomes, not electrochemical p
Externí odkaz:
https://doaj.org/article/9f54284358ba411c8a2526291b9f239a
Autor:
Alexander R. Harris, Carrie Newbold, Dimitra Stathopoulos, Paul Carter, Robert Cowan, Gordon G. Wallace
Publikováno v:
Micromachines, Vol 13, Iss 1, p 103 (2022)
The electrochemical performance of platinum electrodes was assessed in vitro and in vivo to determine the impact of electrode implantation and the relevance of in vitro testing in predicting in vivo behaviour. A significant change in electrochemical
Externí odkaz:
https://doaj.org/article/8bf872afe02b452486bb8d7f961921c1
Autor:
Nicole J. Van Bergen, Sean Massey, Anita Quigley, Ben Rollo, Alexander R. Harris, Robert M.I. Kapsa, John Christodoulou
Publikováno v:
Biochemical Society Transactions. 50:1207-1224
CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene. Individuals with CDD suffer infantile onset, drug-resistant seizures, severe neur
Publikováno v:
Stem Cell Reports. 17:1023-1032
Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient displays symptoms, allo
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
The safe charge injection capacity and charge density of neural stimulating electrodes is based on empirical evidence obtained from stimulating feline cortices. Stimulation induced tissue damage may be caused by electrochemical or biological mechanis
Externí odkaz:
https://doaj.org/article/ddde2b596b2543488c433cafffb2fcde
Publikováno v:
AJOB Neuroscience. 13:230-232
Autor:
Alexander R. Harris, Frederic Gilbert
Publikováno v:
Graefe's Archive for Clinical and Experimental Ophthalmology
Retinit is pigmentosa is an incurable degenerative disease that causes loss of light-sensitive cells in the retina and leads to severe vision impairment. The development of optogenetics has created great hype around its potential to treat retinitis p
Publikováno v:
Molecular Psychology: Brain, Behavior, and Society. 2:8
The potential of organoids and other stem cell-derived tissue constructs (SCTC) to be used for clinical applications is developing rapidly. Subsequently, there is an increasing need to understand and address the ethical, legal and regulatory issues a